A5101439111- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- Reproductive tract infections research
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Nosocomial Infections in ICU
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Clostridium difficile and Clostridium perfringens research
- Bacterial Infections and Vaccines
- Microscopic Colitis
- Reproductive System and Pregnancy
- Diphtheria, Corynebacterium, and Tetanus
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Pelvic floor disorders treatments
- Sepsis Diagnosis and Treatment
Aichi Medical University Hospital
2016-2025
Aichi Medical University
2016-2025
Japan Society of Chemotherapy
2016-2025
Izumi City General Hospital
2011
Gifu University
1996-2007
Gifu University Hospital
2004-2005
Tokyo Teishin Hospital
2000
Meijo Hospital
2000
Kobe Medical Center
2000
Background/Objectives: Clostridioides difficile infection (CDI) poses a significant healthcare challenge, with recurrence rates reaching 30%, leading to substantial morbidity and costs. Fidaxomicin (FDX) bezlotoxumab (BEZ) have shown potential in reducing recurrence; however, real-world data on the efficacy of their combination high-risk CDI patients remain limited. This study aimed evaluate safety FDX + BEZ compared alone risk factors. Methods: ≥two factors treated or were analyzed. Sixteen...
Toxigenic culture and cytotoxicity assays are standard tests for detecting C. difficile infection (CDI). Others include immunochromatographic strips, a rapid diagnostic test that detects glutamate dehydrogenase (GDH toxins simultaneously, the nucleic acid amplification (NAAT) toxin-producing genes. NAAT may not be available in some facilities, so 2-step method can adopted where GDH-positive toxin-negative specimens selected first, then toxigenic is performed these specimens. The testing...
Abstract Background Cross-neutralizing capacity of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is important in mitigating (re-)exposures. Role antibody maturation, the process whereby selection higher affinity augments host immunity, to determine SARS-CoV-2 neutralizing was investigated. Methods Sera from convalescents at 2, 6, or 10 months postrecovery, and BNT162b2 vaccine recipients 3 25 weeks postvaccination, were analyzed. Anti-spike IgG...
The antifungal activity of FK463 against 72 recent clinical isolates Candida albicans (24), glabrata (17), tropicalis (11), krusei (8) and parapsilosis (12) was compared with those amphotericin B, fluconazole itraconazole by means a broth microdilution method specified the National Committee for Clinical Laboratory Standards (NCCLS) document M27-A. lowest drug concentration at which 90% population inhibited (MIC90) C. albicans, glabrata, tropicalis, 0.0156, 0.0313, 0.125 1 mg/L,...
Metabolites are thought as the end products in cellular regulatory processes and their levels show strongest relationships with phenotype. Previously, we showed that administration of Clostridium butyricum MIYAIRI 588 (CBM 588) upregulated protectin D1, an anti-inflammatory lipid metabolite, colon tissue under antibiotic therapy. However, how CBM induces D1 expression whether metabolite has effects on antibiotic-induced inflammation unclear. Therefore, here, evaluated effect metabolism gut...
Abstract Aims Although therapeutic drug monitoring (TDM) of voriconazole is performed in outpatients to prevent treatment failure and toxicity, whether TDM should be all or only selected patients remains controversial. This study evaluated the association between trough concentrations clinical events. Methods We investigated aggravation symptoms, incidence hepatotoxicity visual disturbances, change co‐medications interaction receiving 2017 2021 three facilities. Abnormal were defined as...
Abstract Background Candidemia has emerged as an important nosocomial infection, with a mortality rate of 30–50%. It is the fourth most common bloodstream infection (BSI) in United States and seventh BSI Europe Japan. The aim this study was to assess performance Sequential Organ Failure Assessment (SOFA) score for determining severity prognosis candidemia. Methods We performed retrospective patients admitted hospital candidemia between September 2014 May 2018. evaluated using SOFA Acute...
Abstract Voriconazole is a second-generation azole used to treat serious fungal infections. Visual hallucinations constitute representative adverse event caused by voriconazole. However, its mechanism of action remains unclear. In patients with schizophrenia or Parkinson’s disease, the frequency visual associated brain dopamine levels. This study investigated in treated voriconazole alone combination dopaminergic medicines antagonists, using data collected from Food and Drug Administration...
Although varicella zoster virus (VZV) infection is generally considered self-limiting and shows a favorable outcome, herpes (HZ) can cause several complications such as neurological pain or meningitis, which lowers the patients' quality of life. HZ rarely manifests VZV pneumonia, resulting in poor prognosis with high mortality rate 10-30 % if requiring mechanical ventilation. Here, we present rare successfully managed case pneumonia. A 90-year-old man medical history angina pectoris,...