A5024778096- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- NMR spectroscopy and applications
- MRI in cancer diagnosis
- Ultrasound and Hyperthermia Applications
- Parkinson's Disease Mechanisms and Treatments
- Bone and Joint Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Spectroscopy Techniques in Biomedical and Chemical Research
- Sepsis Diagnosis and Treatment
- Neurological disorders and treatments
- Ultrasound Imaging and Elastography
- Medical Imaging and Analysis
- Cell Image Analysis Techniques
- Musculoskeletal pain and rehabilitation
- Thermal Regulation in Medicine
Friedrich Schiller University Jena
2021-2024
Jena University Hospital
2020-2024
The diagnosis of multiple sclerosis (MS) is usually based on clinical symptoms and signs damage to the central nervous system, which assessed using magnetic resonance imaging. correct interpretation these data requires excellent expertise experience. Deep neural networks aim assist clinicians in identifying MS imaging data. However, before such can be integrated into workflow, it crucial understand their classification strategy. In this study, we propose use a convolutional network identify...
Paramagnetic transition metals play a crucial role as cofactors in various cellular catalytic processes. However, their high concentrations reactive oxidation states can induce oxidative stress, resulting cell dysfunction or death. Hence, it is vital to have methods monitor metal and paramagnetic properties cells for medicine biology. Here we present novel multimodal method in-cell magnetometry enabling direct measurement of magnetic within individual tissue, without prior isolation at room...
Background Preventing sepsis‐associated acute kidney injury (S‐AKI) can be challenging because it develops rapidly and is often asymptomatic. Probability assessment of disease progression for therapeutic follow‐up outcome are important to intervene prevent further damage. Purpose To establish a noninvasive multiparametric MRI (mpMRI) tool, including T 1 , 2 perfusion mapping, probability the S‐AKI. Study Type Preclinical randomized prospective study. Animal Model One hundred forty adult...
Multiple studies have reported a significant dependence of the effective transverse relaxation rate constant (R2*) and phase gradient-echo based (GRE) signal on orientation white matter fibres in human brain. It has also been hypothesized that magnetic susceptibility, as obtained by single-orientation quantitative susceptibility mapping (QSM), exhibits such dependence. In this study, we investigated relationship cohort healthy volunteers. We show R2* follows predicted consistently across...
This work demonstrates the use of echo-shifting in combination with an efficient variable flip angle 3D RARE to reconstruct fat fraction distribution a liver sample, resolving fine structure deposits tissue Dixon based analysis at 9.4T.
It is well established in literature that MRI quantitative parameters such as T2 or diffusion coefficients change significantly immediately after a strenuous exercise session. In this work, we instead focus on the long-term effects of regular repeated physical activity three cohorts characterized by different training regimes. A multiparametric protocol was developed to assess T1, T2, fat fraction, and IVIM values examine differences lumbar spine muscle physiology between cohorts.
Adaptations in muscle physiology due to long-term physical training have been monitored using various methods: ranging from invasive techniques, such as biopsy, less approaches, electromyography (EMG), quantitative magnetic resonance imaging (qMRI) parameters. Typically, these latter parameters are assessed immediately after exercise. In contrast, this work assesses adaptations a set of qMRI obtained at rest the lumbar spine muscles volunteers. To end, we developed multiparametric...
Quantitative susceptibility mapping (QSM) has been successfully applied to study changes in deep grey matter nuclei as well lesional tissue, but its application white complicated by the observed orientation dependence of gradient echo signal. The anisotropic tensor is thought be at origin this dependence, and magnetic anisotropy (MSA) derived from proposed a marker state integrity myelin sheath may therefore particular interest for demyelinating pathologies such multiple sclerosis (MS)....
Attaining reproducible, time-efficient, high spatial resolution and quantitative MRI perfusion images in small animal @9.4T is still challenging. To take a step toward this goal, data from arterial spin labeling (ASL), Flow-sensitive Alternating Inversion Recovery (FAIR), dynamic susceptibility contrast (DSC), pseudo-continuous (pCASL) sequences are compared by assessing cerebral 5 rats, each scanned 3 times. Differences (cerebral blood flow) CBF major brain regions were analyzed, the...
MRI holds high promise to diagnose Parkinson’s disease (PD) at clinical field strength B0. However, it remains unclear which B0 optimizes T2* contrast in substantia nigra, provides diagnostic accuracy. We used quantitative B0=1.5T-9.4T, MR microscopy, and histochemistry characterize the dependence of major contributors R2* (1/T2*): dopaminergic neurons, ferritin, myelin. maps were similar B0=3T-9.4T, all contributions scaled approximately linearly with Hence, mechanisms are across...