A5051436686- Intensive Care Unit Cognitive Disorders
- Antifungal resistance and susceptibility
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Oral microbiology and periodontitis research
- Health Systems, Economic Evaluations, Quality of Life
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Pharmaceutical studies and practices
- Hemodynamic Monitoring and Therapy
- Clinical Nutrition and Gastroenterology
- Electroconvulsive Therapy Studies
- Body Composition Measurement Techniques
- Anesthesia and Neurotoxicity Research
- Antibiotic Use and Resistance
- Tryptophan and brain disorders
- Neurological Complications and Syndromes
- Fungal Biology and Applications
- Neonatal and Maternal Infections
- Spinal Dysraphism and Malformations
University Hospital Ostrava
2017-2023
University of Ostrava
2017-2023
Czech Academy of Sciences, Institute of Physiology
2020-2023
Nemocnice u Sv. Jiří
2020
Background and Aims: Delirium is an acute brain dysfunction a frequent complication in critically ill patients. When present it significantly worsens the prognosis of The aim this study was to evaluate incidence delirium risk factors for mixed group trauma, medical surgical ICU Methods: A prospective observational conducted one six-bed Intensive Care Units University Hospital Ostrava Czech Republic during 12-month period. We evaluated its predisposing precipitating factors. All patients were...
Germination from conidia to hyphae and hyphal propagation of Aspergillus fumigatus are the key pathogenic steps in development invasive pulmonary aspergillosis (IPA). By applying
Summary Detection of serum galactomannan ( GM ) and (1,3)‐β‐ d ‐glucan BG is considered useful for non‐culture diagnosis invasive pulmonary aspergillosis IPA in neutropenic patients. Only few studies evaluated these seromarkers non‐neutropenic patients suspected having . The aim this study was to evaluate both tests together with the Aspergillus fumigatus ‐specific IgG IgA (Ig AG test serological Sera from 87 were retrospectively analysed. Patients categorised into groups proven (n = 10),...
The multiple forms of pulmonary aspergillosis caused by Aspergillus species are the most common respiratory mycoses. Although invasive, analysis diagnostic biomarkers in bronchoalveolar lavage fluid (BALF) is a clinical standard for diagnosing these conditions. BALF samples from 22 patients with proven or probable were assayed human pentraxin 3 (Ptx3), fungal ferricrocin (Fc), and triacetylfusarinine C (TafC) retrospective study. infected group included invasive (IPA) chronic (CPA). data...
In acutely ill patients, particularly in intensive care units or mixed infections, time to a microbe-specific diagnosis is critical successful outcome of therapy. We report the application evolving technologies involving mass spectrometry diagnose and monitor patient’s course. As proof this concept, we studied five patients used two rat models mono-infection coinfection. noninvasive combined monitoring Aspergillus fumigatus Pseudomonas aeruginosa infection. The invasive coinfection was...
Acute kidney injury (AKI) is a consequence of several diseases that can severely damage function. It frequent complication hospitalization and very common in critically ill patients because other serious illnesses, such as septic conditions. New diagnostic options, including renal biomarkers, may help early diagnosis. Our study included 46 patients, 31 with AKI 15 without on admission. Blood samples were collected the first, fourth, seventh days treatment, addition to basic biochemical...
Abstract Background Through regulation of signaling pathways, microRNAs (miRNAs) can be involved in sepsis and associated organ dysfunction. The aims this study were to track the 7-day time course blood miRNAs patients with treated vancomycin, gentamicin, or a non-nephrotoxic antibiotic miRNA associations neutrophil gelatinase-associated lipokalin (NGAL), creatinine, procalcitonin, interleukin-6, acute kidney injury (AKI) stage. Methods Of 46 adult patients, 7 on 20 19 another antibiotic....
Sepsis remains one of the most common causes death worldwide. It is caused by a complex inadequate host responses to infection. also often difficult distinguish sepsis from non-infectious cause systemic inflammatory response syndrome. Early identification an infectious origin may dramatically help improve outcome and reduce mortality. That main reason why clinicians need fast, reliable specific biomarkers for recognition sepsis. Presepsin (sCD-14ST) promising biomarkers, level which...
New biomarker panel was developed and validated on 165 critically ill adult patients to enable a more accurate invasive candidiasis (IC) diagnosis. Serum levels of the panfungal (1,3)-β-D-glucan (BDG) inflammatory biomarkers C-reactive protein, presepsin (PSEP), procalcitonin (PCT) were correlated with culture-confirmed candidemia or bacteremia in 58 107 patients, respectively. The diagnostic utility evaluated sensitivity, specificity, positive predictive value (PPV), negative (NPV). BDG...
Dexamethasone 6 mg in patients with severe COVID-19 has been shown to decrease mortality and morbidity. The effects of higher doses corticosteroid, that would further increase anti-inflammatory effects, are uncertain. objective our study was assess the effect 20 dexamethasone vs. intravenously moderate-to-severe acute respiratory distress syndrome (ARDS) COVID-19. In a multicenter, open-label, randomized trial conducted nine hospitals Czech Republic, we adult ARDS requiring high-flow oxygen,...
<title>Abstract</title> <bold>Background</bold>: Hyperhydration and muscle wasting can be profoundly detrimental in the critically ill. Properly assessing fluid status body composition is not trivial still a considerable challenge. Our study aims to assess feasibility of using Bioelectrical Impedance Vector Analysis (BIVA) monitor hydration skeletal mass ill [including patients on extracorporeal membrane oxygenation (ECMO)], determine effect mortality hyperhydration loss measured by BIVA...
Kyslík je biologicky stěžejní prvek k zajištění života a jeho dodávka do tkání proto precizně regulována. Míra tkáňové oxygenace v současné klinické praxi odhadována na podkladě měření hladiny kyslíku krvi. Nedostatek buněčné úrovni může vést orgánovému selhávání ohrožení života. Při subletální hypoxii dochází aktivaci významných adaptačních procesů s cílem zachování funkce buňky i tkání. Neadekvátní snaha o korekci hypoxie narušení této adaptace riziku nežádoucí hyperoxie. Tento fakt se...
The world currently deals with the SARS-CoV-2 pandemic and its clinical form of Coronavirus Disease, first described in 2019 (COVID-19). Millions patients suffer from dyspnea low oxygenation, many require artificial mechanical ventilation for acute respiratory failure. most prominent problem is Acute Respiratory Distress Syndrome (ARDS), a life-threatening gas exchange impairment resulting hypoxemia, hypercapnia followed by critical tissue hypoxia. best ventilatory setting ARDS, reducing...
PURPOSE OF THE STUDY Persistent catabolism is one of the main causes delayed healing in polytrauma patients. The purpose this study to verify effect early administration an anabolic steroid combination with vitamin D on process bone MATERIAL AND METHODS In prospective study, patients a serious trauma were divided into two groups (a control group and treatment group), being treated nandrolone decanoate, D. all patients, metabolism markers sex hormone levels (men only) monitored through lab...
Amiodaron je velmi účinné a nepostradatelné antiarytmikum v léčbě komorových supraventrikulárních arytmií.Výhodou příznivý hemodynamický profil s nízkým proarytmogenním potenciálem, avšak jeho užívání spojeno se známými kardiálními i extrakardiálními nežádoucími účinky.Při dlouhodobém amiodaronu bývá poměrně častá hepatotoxicita (incidence kolem 25 %), která většinou asymptomatická upravuje po snížení dávky nebo vysazení.Akutní intravenózní aplikaci patří naopak mezi vzácné nežádoucí...
Methemoglobinemia is rare condition of hem iron. Ferrous form iron (Fe2+) oxidised to Ferric (Fe3+). Methemoglobin has reduced ability release oxygen tissues and thereby leads tissue hypoxia. We present case patient with methemoglobinemia unknown etiology. developed during hospitalization. Diferent causes also a treatment possibilities are discussed.
Abstract Background: To improve the accuracy in invasive candidiasis diagnostics, a new biomarker panel has been developed and validated on 165-patient cohort of critically ill adults. Methods: The serum levels inflammatory biomarkers, C-reactive protein, presepsin (PSEP), procalcitonin (PCT), panfungal (1,3)-β-D-glucan (BDG), were correlated with culture-confirmed candidemia or bacteremia 58 107 patients, respectively. diagnostic effect host pathogen biomarkers was expressed using...