A5030559376- Gut microbiota and health
- Child Nutrition and Water Access
- Genomics and Phylogenetic Studies
- Food Security and Health in Diverse Populations
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Machine Learning in Bioinformatics
- Infant Nutrition and Health
- Microbial Community Ecology and Physiology
- Dermatology and Skin Diseases
- RNA and protein synthesis mechanisms
- IL-33, ST2, and ILC Pathways
- Probiotics and Fermented Foods
- Child Nutrition and Feeding Issues
- Protist diversity and phylogeny
- Digestive system and related health
Washington University in St. Louis
2019
Malnutrition and dietary repair Childhood malnutrition is accompanied by growth stunting immaturity of the gut microbiota. Even after therapeutic intervention with standard commercial complementary foods, children may fail to thrive. Gehrig et al. Raman monitored metabolic parameters in healthy Bangladeshi those recovering from severe acute malnutrition. The authors investigated interactions between diet, microbiota development, recovery. Diets were then designed using pig mouse models nudge...
Characterizing the organization of human gut microbiota is a formidable challenge given number possible interactions between its components. Using statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in healthy members Bangladeshi birth cohort sampled from 1 60 months age. The results revealed an "ecogroup" 15 covarying that provide concise description development children this and other low-income countries, means for...
A long-standing challenge in human microbiome research is achieving the taxonomic and functional resolution needed to generate testable hypotheses about gut microbiota’s impact on health disease. With a growing number of live microbial interventions clinical development, this renewed by need understand pharmacokinetics pharmacodynamics therapeutic candidates. While short-read sequencing bacterial 16S rRNA gene has been standard for microbiota profiling, recent improvements fidelity long-read...
Detrimental effects of diarrhea on child growth and survival are well documented, but details the underlying mechanisms remain poorly understood. Recent evidence demonstrates that perturbations to normal development gut microbiota in early life may contribute faltering susceptibility related childhood diseases. We assessed associations between diarrhea, configuration, Peruvian Amazon.Growth, incidence, illness, pathogen infection, antibiotic exposure were monthly a birth cohort 271 children...
Precision microbiome programming for therapeutic applications has been limited by challenges in achieving reproducible colonization of the colon. Previously, we used a porphyran prebiotic to create synthetic niche engraft engineered bacteria into diverse microbiota mice. Here extend that work with biocontainment links essential gene expression presence yielding platform controlled and decolonization humans Bacteroides. We this chassis five-gene oxalate degradation pathway, creating candidate...
ABSTRACT A longstanding challenge in human microbiome research is achieving the taxonomic and functional resolution needed to generate testable hypotheses about gut microbiome’s impact on health disease. More recently, this has extended a need for in-depth understanding of pharmacokinetics pharmacodynamics clinical microbiome-based interventions. Whole genome metagenomic sequencing provides high information metagenome capacity, but required deep costly. For reason, short-read bacterial 16S...
Traditional metagenome binning methods cluster contiguous DNA sequences (contigs) based on uncontextualized features of the which ignores both semantic relationship between genes and positional embedding k-mers. This thesis presents a novel method that addresses these concerns. Firstly, taken from natural language processing literature, sequence representation model - Bidirectional Encoder Representations Transformers(BERT) is utilized to generate contig embeddings. Secondly, two workflows...
A bstract Traditional metagenome binning methods cluster contiguous DNA sequences (contigs) based on uncontextualized features of the which ignores both semantic relationship between genes and positional embedding k-mers. This paper presents a novel method that addresses these concerns. Firstly, taken from natural language processing literature, sequence representation model - Bidirectional Encoder Representations Transformers (BERT) is utilized to generate contig embeddings. Secondly, two...
Abstract The human gut microbiota is central to early-life immune system education, including the establishment of tolerance, and thus represents an important target for development preventative interventions against food allergy (FA). composition microbiota, specific bacterial members within have been shown impact allergic disease in animal models by limiting basophil hematopoiesis, influencing macrophage polarization, enhancing regulatory T cell activity. With a growing body evidence...