There is circumstantial evidence implicating hypoglycaemia in the sudden overnight death of young patients with insulin-dependent (Type 1) diabetes mellitus (IDDM), mechanism which unknown. We have investigated effects on electrocardiogram 15 (8 IDDM and 7 NIDDM) using a high resolution computer-based system. Patients were randomized to either 2 h euglycaemia or (at around 3 mmol l(-1)) during afternoon, hyperinsulinaemic glucose clamps, two visits separated by period at least 4 weeks....

Psychogenic nonepileptic seizures (PNES) superficially resemble epileptic seizures. Little is known about ictal autonomic nervous system (ANS) activity changes in epilepsy and PNES. This study compares heart rate variability (HRV) parameters as a reflection of ANS tone PNES, explores differences between interictal both patient groups.Ictal HRV were extracted from single-lead electrocardiography (ECG) data collected during video-electroencephalography (EEG) recordings 26 patients with...

OBJECTIVE Hypoglycemia may exert proarrhythmogenic effects on the heart via sympathoadrenal stimulation and hypokalemia. Hypoglycemia-induced cardiac dysrhythmias are linked to “dead-in-bed syndrome,” a rare but devastating condition. We examined effect of nocturnal daytime clinical hypoglycemia electrocardiogram (ECG) in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS Thirty-seven individuals diabetes underwent 96 h simultaneous ambulatory ECG blinded continuous interstitial...

Although a clear link between diabetic peripheral neuropathy (DPN) and autonomic is recognized, the relationship of with subtypes DPN less clear. This study aimed to investigate painless painful DPN.Eighty subjects (20 healthy volunteers, 20 no DPN, DPN) underwent detailed neurophysiological investigations (including conventional function tests [AFTs]) spectral analysis short-term heart rate variability (HRV), which assesses sympathovagal modulation rate. Various frequency-domain low...

Abstract Background Autonomic neuropathy is a common and serious complication of diabetes. Early detection essential to enable appropriate interventional therapy management. Dynamic pupillometry has been proposed as simpler more sensitive tool detect subclinical autonomic dysfunction. The aim this study was investigate pupil responsiveness in diabetic subjects with without cardiovascular (CAN) using dynamic two sets experiments. Methods During the first experiment, one flash administered...

Epilepsy is a neurological disorder that causes changes in the autonomic nervous system. Heart rate variability (HRV) reflects regulation of cardiac activity and system tone. The early detection epileptic seizures could foster use new treatment approaches. This study presents methodology for prediction using HRV signals. Eigendecomposition parameter covariance matrices was used to create an input support vector machine (SVM)-based classifier. We analyzed clinical data from 12 patients (9...

Abstract Objective Automated seizure detection of focal epileptic seizures is needed for objective quantification to optimize the treatment patients with epilepsy. Heart rate variability (HRV)‐based using patient‐adaptive threshold logistic regression machine learning (LRML) methods has presented promising performance in a study Danish patient cohort. The this was assess generalizability novel LRML algorithm by validating it dataset recorded from long‐term video‐EEG monitoring (LTM)...

Autonomic neuropathy (AN) is a common and serious complication of diabetes. Early detection essential to enable appropriate interventional therapy. It has long been recognized that subjects with diabetic peripheral (DPN) are at much greater risk developing AN, but there currently no simple screening tool assess them. The aim this study was investigate pupil responsiveness in without DPN using dynamic pupillometry. During the first test, one flash administered response recorded for 3 seconds....

An intense electric field can be applied to increase the membrane conductance G(m) and consequently, conductivity of cell suspension. This phenomenon is called electroporation. mechanism used in a wide range medical applications, genetic engineering, therapies. Conductivity measurements suspensions were carried out during application fields from 40 165 kV/m. Experimental results analyzed with two electroporation models: asymptotic model was estimate at beginning end pulse, extended Kinosita...

Abstract Electrochemotherapy is a combination of high electric field and anticancer drugs. The treatment basis electroporation or electropermeabilization the cell membrane. Electroporation threshold phenomenon and, for efficient treatment, an adequate local distribution within treated tissue important. When this not enough, there regrown tumor cell; however, if it stronger than necessary, permanent damage to occurs. In dogs, electrochemotherapy yet established mast in veterinary medicine,...

Most patients with diabetes mellitus are asymptomatic, which leads to delayed and more complex treatment. At the same time, most individuals routinely subjected standard clinical laboratory examinations, create large health datasets over a lifetime. Computer processing has been used search for anomalies predict diseases using examinations. This work studied machine learning models support screening of through routine tests data from 62,496 patients. The classification regression were...

There is circumstantial evidence implicating hypoglycaemia in the sudden overnight death of young patients with insulin-dependent (Type 1) diabetes mellitus (IDDM), mechanism which unknown. We have investigated effects on electrocardiogram 15 (8 IDDM and 7 NIDDM) using a high resolution computer-based system. Patients were randomized to either 2 h euglycaemia or (at around 3 mmol l−1 ) during afternoon, hyperinsulinaemic glucose clamps, two visits separated by period at least 4 weeks....

During hypoglycaemia, typically there is a change in the surface ECG characterized by flattened and prolonged T wave, often accompanied fused U wave. The QT interval useful parameter for quantifying morphology. However, reliable measurement of not straightforward, particularly hypoglycaemic objective this study was to compare ability two methods distinguish between ECGs recorded during euglycaemia hypoglycaemia. first method involves manually setting intersection isoelectric line wave or,...

In this study, we investigated the use of empirical mode decomposition (EMD)-based features extracted from electrocardiogram (ECG) RR interval signals to differentiate between different levels cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). This study involved 60 participants divided into three groups: no CAN, subclinical and established CAN. Six EMD (area analytic signal representation—ASRarea; area ellipse evaluated second-order difference...

OBJECTIVE To assess the effects of short-term antecedent hypoglycemia on responses to further 2 days later in patients with IDDM. RESEARCH DESIGN AND METHODS We studied eight type I diabetic without unawareness or autonomic neuropathy during two periods at least 4 weeks apart. On day 1, h either clamped hyperinsulinemic (60 mU · m−2 min−1) 2.8 mmol/l euglycemia 5.0 were induced. Hyperinsulinemic was induced 40 min glucose steps 5.0, 4.0, 3.5, 3.0, and 2.5 mmol/l. Catecholamine levels...

Modularity is one of the most important aspects continuous development a system. With modular platform, it possible to scale functionalities, adding more features or keeping just needed ones. A very robust and effective solution for real-time monitoring problem an automotive system whose architecture will be used as base photoplethysmography (PPG) acquisition platform. The PPG platform uses reflective configuration on wrist u-health applications allow medical data management individual...