A5085603742- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Cord Injury Research
- Traumatic Brain Injury Research
- Stress Responses and Cortisol
- Migraine and Headache Studies
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Pain Mechanisms and Treatments
- Trigeminal Neuralgia and Treatments
- Muscle metabolism and nutrition
- Long-Term Effects of COVID-19
- Adenosine and Purinergic Signaling
- Thermal Regulation in Medicine
- Transcranial Magnetic Stimulation Studies
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
Universidade Federal de Santa Maria
2012-2025
Universidade Federal de Santa Catarina
2018-2024
Brazilian Institute of Neuroscience and Neurotechnology
2021-2024
University of Maryland, Baltimore
2024
Universidade Federal do Rio Grande do Sul
2012
Background/Objectives: Spinal cord injury (SCI) is a devastating condition that leads to cascade of cellular and molecular events, resulting in both primary secondary damage. Among the many cells involved post-SCI environment, glial spinal brain are pivotal determining trajectory repair. Methods: While recent SCI studies have shown changes genotype following injury, exactly how these alterations occur after damage remains unknown. In this sense, systemic inflammatory molecules could be...
Traumatic brain injury (TBI) is a major cause of acquired epilepsy, and significant resources are required to develop better understanding the pathologic mechanism as targets for potential therapies. Thus, we decided investigate whether physical exercise after fluid percussion (FPI) protects from oxidative neurochemical alterations well behavioral electroencephalographic (EEG) seizures induced by subeffective convulsive doses pentylenetetrazol (PTZ; 35 mg/kg). Behavioral EEG recordings...
The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein lipid oxidation, antioxidant enzyme activity endogenous non‐enzymatic content in kidney circulating fluids, well serum biochemical (cholesterol, triglycerides, urea creatinine) from Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME)‐induced hypertension treated rats. Animals were divided into four groups ( n = 10): Control,...
Throughout the world, traumatic brain injury (TBI) is one of major causes disability, which can include deficits in motor function and memory, as well acquired epilepsy. Although some studies have shown beneficial effects physical exercise after TBI, prophylactic are poorly understood. In current study, we demonstrated that TBI induced by fluid percussion (FPI) adult male Wistar rats caused early impairment (24 h), learning deficit (15 days), spontaneous epileptiform events (SEE), hilar cell...
An early inflammatory response and oxidative stress are implicated in the signal transduction that alters both hepatic redox status mitochondrial function after traumatic brain injury (TBI). Peripheral oxidative/inflammatory responses contribute to neuronal dysfunction TBI Exercise training profile of oxidative-inflammatory liver protects against acute hyperglycaemia a cerebral TBI. Approaches such as exercise training, which attenuates damage TBI, may have therapeutic potential through...
BackgroundCholinergic enzyme activities are altered in hypertension, reflecting a low-grade inflammation.Regular physical exercise exerts anti-inflammatory effects and has been described as coadjutant the treatment of hypertension.In this study, we investigated effect 6 weeks swimming training on cholinergic (acetylcholinesterase butyrylcholinesterase) Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. MethodsThe rats were divided into 4 groups: control (n =...
Post-traumatic headache (PTH) is a debilitating condition that affects individuals with different levels of traumatic brain injury (TBI) severity. The difficulties in developing an effective treatment are related to lack understanding the complicated mechanisms and neurobiological changes function after injury. Preclinical studies have indicated peripheral central sensitization trigeminal nociceptive pathways contributes PTH. While recent imaging uncovered widespread functional connectivity...
Spinal cord injury (SCI) is a cause of long-term disability, and one the main problems sensorimotor response impairment. Thus, become important treatments that reduce progressive secondary damage causes loss spared neurons. Due to oxidative stress inflammation interaction after damage, we tested if diacerein, classic pharmacologic anti-inflammatory, could cell in long term recover responses SCI rats. Clip-compression model female Wistar rats caused severe locomotory performance showed...
This study proposes a closed-loop brain-machine interface (BMI) based on spinal cord stimulation to inhibit epileptic seizures, applying semi-supervised machine learning approach that learns from Local Field Potential (LFP) patterns acquired the pre-ictal (preceding seizure) condition.