A5005911170- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
- Nutrition, Genetics, and Disease
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- S100 Proteins and Annexins
- Metabolomics and Mass Spectrometry Studies
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Inflammasome and immune disorders
- Breast Cancer Treatment Studies
- Hormonal Regulation and Hypertension
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Nuclear Physics and Applications
- Ubiquitin and proteasome pathways
- Paraoxonase enzyme and polymorphisms
- Circular RNAs in diseases
- Coenzyme Q10 studies and effects
- X-ray Spectroscopy and Fluorescence Analysis
- Trace Elements in Health
- Bioeconomy and Sustainability Development
Acıbadem Adana Hospital
2019-2022
Acıbadem University
2018-2021
Istanbul Technical University
2013-2016
Istanbul University
2010
COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared throughout the World and currently affected more than 9 million people caused death of around 470,000 patients. The novel strain disease is transmittable at a devastating rate with high hospitalization even so for elderly population. Naso-oro-pharyngeal swab samples as first step towards detecting suspected infection SARS-CoV-2 provides non-invasive method PCR testing confidence rate. Furthermore, proteomics...
In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in extracellular matrix are consequences aging may be related to Alzheimer’s disease (AD). this study, we aimed demonstrate hippocampal fluid proteins vivo using 5XFAD mouse model. Samples were obtained from hippocampi mice ( n = 6) their non-transgenic littermates by intracerebral push-pull perfusion technique at 3 months age, representing pre-pathological stage AD. Proteins...
We described the serological prevalence of West Nile Virus (WNV) antibodies among human population in a historical and strategic region Turkey. A serologic survey was conducted based on suspected cases April, 2009, Mesopotamia Turkey, villages that were located alongside Zergan River. All sera tested by enzyme-linked immunosorbent assay ELISA (Euroimmune™), positive samples immunofluorescent (IFA; Euroimmune™). As confirmation, neutralizing against WNV microneutralization (MNTA). In total,...
Alzheimer’s disease (AD) is a progressive disorder characterized by variety of molecular pathologies causing cortical dementia with prominent memory deficit. Formation the pathology, which begins decades before diagnosis disease, highly correlated clinical symptoms. Several proteomics studies were performed using animal models to monitor alterations brain tissue proteome at different stages AD. However, changes in regions newborn transgenic mouse model have not been investigated yet. To this...
COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared throughout the World and currently affected more than 3.6 million people caused death of around 252,000 people. The novel strain disease is transmittable at a devastating rate with high hospitalization even so for elderly population. Currently 50,000 patients are in seriously critical situation. Although 1.2 recovered from there still 2.1 Million active cases. Naso-oro-pharyngeal swab samples as first step...
Background: Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. The diagnosis of according to symptomatic events still puzzling task. Developing biomarker-based, low-cost, high-throughput test, readily applicable in clinical laboratories, dramatically impacts the rapid reliable detection disease. Objective: This study aimed develop an accurate, sensitive, screening tool for diagnosing disease, which can significantly reduce...
Expression of kallikrein-11 (KLK11) has been found to be related the prognosis various human cancer types but its physiological functions in steps breast (BC) progression are still unknown.BC and adjacent normal tissue samples were collected from 28 patients. KLK11 expression levels determined by real-time polymerase chain reaction for each sample associations with known prognostic features statistically analyzed.Although there was slight up-regulation tumor tissues overall, significant...
Background and Objective: Antimycin A (AntA) is a potent Electron Transport System (ETS) inhibitor exerting its effect through inhibiting the transfer of electrons by binding to quinone reduction site cytochrome bc1 complex (Complex III), which known be impaired in Huntington’s Disease (HD). The current studies were undertaken investigate III inhibition SH-SY5Y cell line delineate molecular cellular processes, may play role pathogenesis HD. Methods: We treated neuroblastoma cells with AntA...
Abstract Background and aims It is becoming evident that local estrogen exposure important in postmenopausal breast cancer patients. The microenvironment established by stromal cells based on communication with tumor essential to development, invasion, metastasis. Here we investigated aromatase activity levels both matched tissues showing their impact the manufacturing of progression cases invasive ductal carcinoma (IDC). Methods Tumor (T) tumor-associated stroma (TAS) neighboring were...
The relationship between steroid hormones and breast cancer has been known for decades. Steroid play an active role in cellular proliferation this type show their mitogenic effects by binding to estrogen, progesterone, androgen receptors. Reducing the concentrations of systemic circulation may be insufficient prevent progression cancer, as it will enable selection tumor/peripheral cells that synthesize steroids from circulating precursors. intracrine capacity tissues now also become emergent...
Objective: A considerable level of evidence has accumulated about the breast cancer risk-reducing effect consuming specific flavonoids, through increasing amount research and epidemiologic studies. Different flavonoids may have different cellular bioavailability favor, i.e., occurrence a hormetic effect, thus it is important to evaluate cells’ response doses flavonoids. This study aims investigate alterations biological pathways in hormone-positive (HR+) cell line as resemblance for most...