A5078972783- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- VLSI and Analog Circuit Testing
- Diffusion and Search Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Semiconductor materials and devices
- Immune cells in cancer
- Point processes and geometric inequalities
- 3D IC and TSV technologies
- Software System Performance and Reliability
- Morphological variations and asymmetry
- Cancer Cells and Metastasis
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Fault Detection and Control Systems
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Circular RNAs in diseases
- Parallel Computing and Optimization Techniques
- Gene expression and cancer classification
Yale University
2022-2024
City University of Hong Kong
2024
Sun Yat-sen University
2023
Anhui University of Traditional Chinese Medicine
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen Memorial Hospital
2023
University of Miami
2022
IBM (United States)
2009-2021
The advancement of single cell RNA-sequencing (scRNA-seq) technology has enabled the direct inference co-expressions in specific types, facilitating our understanding cell-type-specific biological functions. For this task, high sequencing depth variations and measurement errors scRNA-seq data present two significant challenges, they have not been adequately addressed by existing methods. We propose a statistical approach, CS-CORE, for estimating testing co-expressions, that explicitly models...
Stem cell differentiation requires dramatic changes in gene expression and global remodeling of chromatin architecture. How when remodels relative to the transcriptional, behavioral, morphological during remain unclear, particularly an intact tissue context. Here, we develop a quantitative pipeline which leverages fluorescently-tagged histones longitudinal imaging track large-scale compaction within individual cells live mouse. Applying this epidermal stem cells, reveal that cell-to-cell...
Learning the latent network structure from large scale multivariate point process data is an important task in a wide range of scientific and business applications. For instance, we might wish to estimate neuronal functional connectivity based on spiking times recorded collection neurons. To characterize complex processes underlying observed data, propose new flexible class nonstationary Hawkes that allow both excitatory inhibitory effects. We using efficient sparse least squares estimation...
Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD cognitive dysfunction, although the specific regulatory mechanism remains unclear. Tx-J mice, 82% sequence homology ATP7B gene to human gene, are considered most suitable model for WD. This study employs deep sequencing investigate differences in RNA transcript profiles, both coding and non-coding, as well functional characteristics network involved impairment. function tx-J...
DDR5 Differential DIMM (DDIMM) is being defined in JEDEC and will be introduced to the market 2020. DDIMM uses OMI (OpenCAPI Memory Interface) as host interface. On printed circuit board (PCB), minimum data transfer rate per differential pair over bus 25.6Gbps. This a significant increase for DRAM modules conventional single-ended transferring DIMMs. For example, LRDIMM pin 3.2Gbps. Careful attention must paid bill of materials control its cost towards general acceptance this new technology....
The inference of gene co-expressions from microarray and RNA-sequencing data has led to rich insights on biological processes disease mechanisms. However, the bulk samples analyzed in most studies are a mixture different cell types. As result, inferred confounded by varying type compositions across only offer an aggregated view regulations that may be distinct advancement single (scRNA-seq) technology enabled direct specific types, facilitating our understanding cell-type-specific functions....
Heritability and genetic covariance/correlation quantify the marginal shared effects across traits. They offer insights on architecture of complex traits diseases. To explore how variations contribute to brain function variations, we estimated heritability correlation cortical thickness, surface area, volume 33 anatomically predefined regions in left right hemispheres, using summary statistics genome-wide association analyses 31,968 participants UK Biobank. characterize relationships between...
Tackling High-Dimensional Tensor Clustering In the paper “Jointly Modeling and Tensors in High Dimensions,” Cai, Zhang, Sun address challenge of jointly modeling clustering tensors by introducing a high-dimensional tensor mixture model with heterogeneous covariances. The proposed exploits intrinsic structures data. authors develop computationally efficient expectation conditional maximization (HECM) algorithm show that HECM iterates, an appropriate initialization, converge geometrically to...
Modeling event patterns is a central task in wide range of disciplines. In applications such as studying human activity patterns, events often arrive clustered with sporadic and long periods inactivity. Such heterogeneity poses challenges for existing point process models. this article, we propose new class processes that alternate between active inactive states. The proposed model flexible, highly interpretable, can provide useful insights into patterns. A composite likelihood approach EM...
Server system requirement drives the evolution of 3D DRAM technologies. The new generation provides form factor, electrical and power performance benefits. Meanwhile it brings in a more complicated design, assembly technologies failure mechanisms. optimum technology is determined by complex tradeoff benefits, cost, time to market reliability. characteristics for DDR2, DDR3 future server memory are analyzed detail. TSV (Through Silicon Via) array stacking expected bring superior which could...
Abstract Stem cell differentiation requires dramatic changes in gene expression and global remodeling of chromatin architecture. How when remodels relative to the transcriptional, behavioral, morphological during remain unclear, particularly an intact tissue context. Here, we develop a quantitative pipeline which leverages fluorescently-tagged histones longitudinal imaging track large-scale compaction within individual cells live mouse. Applying this epidermal stem cells, reveal that...
Abstract Background The TNNI3 gene, responsible for encoding the inhibitory subunit of troponin complex known as cardiac I (cTnI), has significant implications in cardiology research. Despite reports its abnormal expression human carcinoma cells, precise functions cancer remain largely unexplored. present study seeks to examine prognostic significance papillary renal cell (pRCC). Methods mRNA profiles were acquired from Cancer Genome Atlas (TCGA) database identify candidate genes using...
Abstract Background: The TNNI3 gene, responsible for encoding the inhibitory subunit of troponin complex known as cardiac I (cTnI), has significant implications in cardiology research. Despite reports its abnormal expression human carcinoma cells, precise functions cancer remain largely unexplored. present study seeks to examine prognostic significance papillary renal cell (pRCC). Methods: mRNA profiles were acquired from Cancer Genome Atlas (TCGA) database identify candidate genes using...
1553B system is described and an application layer communication protocol based on introduced in this paper.The adopts the 'broadcast-and-echo' strategy, which can provide lots of fault information many ways to improve ability diagnosis.The validity proved by analysis experiments.The proposed practical with low cost, has been applied GNC a spacecraft.
Differential DIMM (DDIMM) is being defined in JEDEC and uses OMI as a host interface with the data transfer rate specified at 25.6Gb/s present 51.2Gb/s future. A prior 2019~20 study [13] of full channel simulation electrical test initial DDR4 DDIMM engineering samples demonstrated feasibility to achieve BER 10^-15 bus rate. In this study, result production environment much larger sample size will be analyzed for robustness. addition, explore scale 32Gb/s time domain eye diagram analysis...