A5072758765- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Face Recognition and Perception
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Action Observation and Synchronization
- Psychology of Moral and Emotional Judgment
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Tumor Detection and Classification
- Stroke Rehabilitation and Recovery
- Psychosomatic Disorders and Their Treatments
- Amyotrophic Lateral Sclerosis Research
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Language, Metaphor, and Cognition
- Neurological disorders and treatments
University of California, San Francisco
2011-2025
University Memory and Aging Center
2011-2025
Center for Neurosciences
2024
Large-scale brain networks are integral to the coordination of human behaviour, and their anatomy provides insights into clinical presentation progression neurodegenerative illnesses such as Alzheimer’s disease, which targets default mode network, behavioural variant frontotemporal dementia, a more anterior salience network. Although network is recruited when healthy subjects deliberate about ‘personal’ moral dilemmas, patients with disease give normal responses these dilemmas whereas...
Theory of mind (ToM) is crucial for socioemotional interaction. ToM deficits may explain behavioral changes in dementia, especially Alzheimer's disease (AD) and frontotemporal dementia (FTD). This study examined the psychometrics a new test healthy adults, identified differences syndromes, assessed if scores predict neuropsychiatric function real-life behavior. The UCSF Cognitive Emotional Perspective Taking Test (CEPT) was evaluated 195 adults (age: 42.69 ± 16.20) clinic cohort 304...
Non-cognitive features including personality changes are increasingly recognized in the three PPA variants (semantic-svPPA, non fluent-nfvPPA, and logopenic-lvPPA). However, differences emotion processing among its association with white matter tracts unknown. We compared detection across healthy controls (HC), related them to tract integrity cortical degeneration. Personality traits group were also examined relation tracts. Thirty-three patients svPPA, nfvPPA, lvPPA, 32 HC underwent...
Intentional facial expression of emotion is critical to healthy social interactions. Patients with neurodegenerative disease, particularly those right temporal or prefrontal atrophy, show dramatic socioemotional impairment. This was an exploratory study examining the neural and behavioral correlates intentional in disease patients controls. One hundred thirty three participants (45 Alzheimer's 16 variant frontotemporal dementia, 8 non-fluent primary progressive aphasia, 10 supranuclear...
Abstract Introduction The Behavioral Inhibition System ( BIS ) and the Activation BAS have been theorized as neural systems that regulate approach/withdrawal behaviors. activation/inhibition balance may change in neurodegenerative disease based on underlying alterations supporting motivation behaviors, which turn be reflected neuropsychiatric symptoms. Method A total of 187 participants (31 patients diagnosed with behavioral variant FTD [bvFTD], 13 semantic primary progressive aphasia...
In 2009, inclusions containing the fused in sarcoma (FUS) protein were identified as a third major molecular class of pathology underlying behavioral variant frontotemporal dementia (bvFTD) syndrome. Due to low prevalence FUS pathology, few clinical descriptions have been published and none provides information about specific social-emotional deficits despite evidence for severe manifestations this disorder. We evaluated patient with bvFTD due using comprehensive battery cognitive social-...
ABSTRACT Learning objective To validate a novel video-based emotion identification measure in persons with neurodegeneration and show correspondence to emotion-relevant brain systems Background Given advances disease-modifying therapies for dementia, the dementia field needs objective, practical behavioral assessment tools patient trial selection monitoring. The Dynamic Affect Recognition Test (DART) was designed remedy limitations of instruments typically used deficits (PWD). Method...
OBJECTIVE: Evaluate a novel video-based emotion measure in neurodegenerative patients; demonstrate that deficits predict atrophy emotion-relevant brain systems. BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) patients show disproportionately impaired comprehension, yet traditional picture-based tests without real-life impairment. The Dynamic Affect Recognition Test (DART) is tablet-based test designed to quickly assess comprehension with ecologically valid stimuli....
Objective: To determine the neuroanatomic basis for impaired self-awareness of functional abilities in neurodegenerative patients. Background Neurodegenerative patients, particularly those with right-brain damage, present poor awareness their limitations that may exacerbate already jeopardized decision-making and worsen behavior. However, structural anatomic correlates this deficit remain unclear. Design/Methods: 124 participants (27 Alzheimer9s disease, 17 behavioral variant frontotemporal...
Objective: To investigate functional activity in the default mode network during moral judgment frontotemporal dementia. Background Behavioral variant dementia (bvFTD) is marked by increased resting-state connectivity within (Zhou et al, 2010), while Alzheimer9s disease decreased this (Greicius 2004). However, relationship between large-scale changes resting state and alterations patients9 behavior not straightforward. For instance, decision making personal dilemmas activates nodes of...