A5101722432- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Chemical Reactions and Isotopes
- Mechanical Behavior of Composites
- Textile materials and evaluations
- Cancer-related molecular mechanisms research
- Image Processing and 3D Reconstruction
- Soft Robotics and Applications
- Topology Optimization in Engineering
- Ammonia Synthesis and Nitrogen Reduction
- Tribology and Wear Analysis
- Lubricants and Their Additives
- Aquaculture Nutrition and Growth
- Liver Disease Diagnosis and Treatment
- Asymmetric Hydrogenation and Catalysis
- Animal Genetics and Reproduction
- Winter Sports Injuries and Performance
- Food Supply Chain Traceability
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- Chemical Synthesis and Analysis
- Educational Robotics and Engineering
- Chronic Myeloid Leukemia Treatments
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Huazhong University of Science and Technology
2021-2022
Tongji Hospital
2021-2022
National Health and Family Planning Commission
2021
Sichuan University
2014-2015
State Key Laboratory of Biotherapy
2014-2015
Shinshu University
2009-2011
Abstract Background Pulmonary hypertension (PH) is a severe and progressive vascular disease for which early diagnosis risk stratification are critical improving patient outcomes. However, current diagnostic approaches exhibit limitations in achieving precise prediction. This study aimed to develop validate machine learning-based prediction model that integrates MRI-derived variables PH assessment. Methods retrospective enrolled 210 participants who underwent MRI at Zhongnan Hospital of...
<title>Abstract</title> <bold>Background</bold>: Pulmonary hypertension (PH) is a severe and progressive vascular disease for which early diagnosis risk stratification are critical improving patient outcomes. However, current diagnostic approaches exhibit limitations in achieving precise prediction. This study aimed to develop validate machine learning-based prediction model that integrates MRI-derived variables PH assessment. <bold>Methods</bold>: retrospective enrolled 210 participants who...
<sec> <title>BACKGROUND</title> Pulmonary hypertension (PH) is a progressive disorder characterized by elevated pulmonary artery pressure and increased vascular resistance, ultimately leading to right heart failure. Early detection critical for improving patient outcomes. </sec> <title>OBJECTIVE</title> To establish novel machine learning-based diagnostic model PH. <title>METHODS</title> A the early of was developed through two-step approach. First, Recursive Feature Elimination (RFE)...
Abstract A highly effective and operationally simple method for the deuteration of phenols using NaOH as a catalyst D 2 O deuterium source is presented. high regioselectivity ortho and/or para hydrogens relative to oxygen atom was achieved, well degree incorporation. The also has functional‐group tolerance, allowed complex pharmaceutically interesting substrates.
This paper describes a mini window-cleaning robot (WCR) that was specially designed for utilizing in domestic environment. WCR climbs on the surface of window glass by means four suction cups, and wipes simultaneously with rotational wiper. is characterized as lightweight mini-size. In robot, two beams are set close to rear forward main body. The cups positioned at both sides each beam. These function legs locomotion. Two pairs diagonal position suck alternately when moves. basic...
Nintedanib is a novel triple angiokinase inhibitor that inhibits three growth factors simultaneously. Deuterated derivatives of nintedanib at certain metabolically active sites were prepared and evaluated in vitro vivo . In particular, deuterated compound SKLB‐C2202 had significantly improved pharmacokinetic properties compared with nintedanib. These efforts lay the foundation for further investigating druggability SKLB‐C2202.
Abstract Hypoxic pulmonary hypertension (HPH) is characterized by elevated artery resistance and vascular remodeling. Endoplasmic reticulum stress (ERS) reported to be involved in HPH, but the underlying mechanisms remain uncertain. We found that Xbp1s, a potent transcription factor during ERS, was hypoxic‐cultured rat PASMCs lung tissues from HPH rats. Our vitro experiments demonstrated overexpressing Xbp1s can promote proliferation, cell viability, migration inhibit apoptosis of PASMCs,...
A kind of system used for bobbin quality controlling tracing based on radio frequency identification (RFID) technology is discussed in this paper. The fundamental obstacle control each spindle spinning frame the loss information associated with bobbins and spindles after point‐of‐spinning. serial number identified recorded automatically via non‐touching dual‐directional data communication RFID technique. basic qualitative provided by a PC B‐MIS (Bobbin Management Information System) through...
Spliced X‑box binding protein 1 (XBP1s) has been reported to participate in the pathogenesis of numerous types cancer; however, whether XBP1s plays a role lung cancer remains be elucidated. In present study, bioinformatics analysis was performed determine mRNA expression level XBP1 and adjacent normal tissues. Gene Ontology terms, pathway enrichment Pearson's correlation were investigate possible mechanism involved. Western blot reverse transcription‑quantitative PCR quantify target...
Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling. Exploring new therapy target urgent. The purpose of the present study to investigate whether and how spliced x-box binding protein 1 (xbp1s), key component endoplasmic reticulum stress (ERS), contributes pathogenesis PH. Forty male SD rats were randomly assigned four groups: Control, Monocrotaline (MCT), MCT+AAV-CTL (control), MCT+AAV-xbp1s. xbp1s levels found be elevated in lung tissues MCT...
Abstract The friction properties of vapor‐grown carbon nanofibers (VGCFs) reinforced natural rubber (NR) composites were investigated with the ball‐on‐plate sliding test. A mechanism was proposed on basis viscoelastic properties, morphology and hardness composites, determined using dynamic mechanical analysis, optical microscopy, field emission scanning electron transmission microscopy a hardness‐testing device. behavior NR/VGCF showed three different stages: an increment trend at first...
The 8-shape 3D composites were fabricated by using woven fabrics of glass fibers as the reinforcement and unsaturated polyester resin matrix with hand lay-up molding technique. In fabric, two groups binder yarns in warp direction, connecting top bottom skins, form 8 shape. four-point bending property was tested. supporting methods, including warp- weft-supporting, analyzed according to direction shape this study. Experimental results showed that onset fractures weft-supporting method larger...
Mathematical formulations for stiffness of the composite, reinforced by "8" shape three dimensional woven fabric, were investigated utilizing four supporting methods from different directions in composite.The divided into top-warp, top-weft, bottom-warp, and bottom-weft methods, mechanical modeling all set up.As first part research, mathematical deduced theoretically methods.