A5054023573- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Sarcoma Diagnosis and Treatment
- Animal Genetics and Reproduction
- interferon and immune responses
- Environmental Toxicology and Ecotoxicology
- Physiological and biochemical adaptations
- Microplastics and Plastic Pollution
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Invertebrate Immune Response Mechanisms
- Ion Transport and Channel Regulation
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Cancer-related molecular mechanisms research
- Identification and Quantification in Food
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- RNA modifications and cancer
- Sperm and Testicular Function
- Cancer-related gene regulation
- Hemodynamic Monitoring and Therapy
Clemson University
2024-2025
Center for Human Genetics
2025
Greenwood Genetic Center
2025
Northern Jiangsu People's Hospital
2025
Henan Normal University
2022-2024
Shanghai Ocean University
2016-2024
First Affiliated Hospital of Anhui Medical University
2022-2024
Anhui Medical University
2022-2024
Henan Province Water Conservancy Survey and Design Research
2024
Xi'an Jiaotong University
2016-2023
The erythrocytes or red blood cells (RBCs) and leucocytes white (WBCs) are the most abundant cell types in circulatory system of vertebrates. RBCs responsible for gas exchange while WBCs solely involved with immunity. In this study, we present evidence that fish despite their respiratory role they also express immune-related genes responses teleost fish, Nile tilapia (Oreochromis niloticus). Fluorescent staining identified presence numerous mitochondria lysosomes RBCs. RNA sequencing led to...
Treatment options for patients with high-risk metastatic clear cell renal carcinoma (mccRCC) include immune checkpoint inhibitors and tyrosine kinase (TKIs), but clinical manifestations treatment of these are rarely reported because cardiac metastases abrupt circulatory disorders very rare there no precise guidelines to follow. In this study, we analyzed discussed the characteristics, related pathogenesis strategies kidney cancer, so as provide reference diagnosis tumors. The patient was...
The 40S ribosomal subunit recycling pathway is an integral link in the cellular quality control network, occurring after translational errors have been corrected by ribosome-associated (RQC) machinery. Despite our understanding of its role, impact translation on metabolism remains poorly understood. Here, we reveal a conserved role (USP10-G3BP1) complex regulating mitochondrial dynamics and function. binds to fission-fusion proteins located at hotspots, functional assembly endoplasmic...
Hepcidin is a liver-derived peptide hormone that related to iron balance and immunity in humans. However, its function Siniperca chuatsi has not been well elucidated. In this study, we analyzed the expression of S. hepcidin (Sc-hep) gene. Sc-hep was specifically expressed liver appeared be one most highly genes liver. After spleen kidney necrosis virus (ISKNV) infection lipopolysaccharide (LPS) polyinosinic-polycytidylic acid (Poly I:C) stimulation, increased by approximately 110, 6500, 225...
Sepsis-induced myocardial dysfunction (SIMD) is a severe complication in sepsis, manifested as systolic dysfunction, which associated with poor prognosis and higher mortality. Mitophagy, self-protective mechanism maintaining cellular homeostasis, plays an indispensable role cardioprotection. This study aimed to unveil the cardioprotective effects of Baricitinib on LPS-induced its effect mitophagy. Herein, we demonstrated that LPS induced initiated mitophagy septic mice hearts. Despite...
Purpose. This study investigated the prognostic value of albumin-to-fibrinogen ratio (AFR) in patients with sepsis as a consequence infection at various sites. Methods. A total 300 caused by sites, who met diagnostic criteria for hospitalized intensive care unit, were enrolled this study. The observational endpoint was 28-day mortality. Cox proportional hazard regression analysis performed to determine potential factors mortality these septic patients. Receiver operating characteristic (ROC)...
Abstract Papillary thyroid carcinoma (PTC) is a common malignancy in tissue. However, the molecular mechanism of PTC tumor progression remains unknown. The hedgehog (Hh) pathway thought to play key role during development. Here we investigate effects glioma‐associated oncogene protein‐2 (Gli2), an important transcription factor Hh‐signaling pathway, on PTC. Gli2 and forkhead box E1 (FOXE1) protein levels were upregulated tissues patients cell lines. Using line TPC‐1, show that small...
Tea polysaccharides plays a role in lipid metabolism, antioxidant capacity and immunity of mammals. To investigate the functions tea on fish, common carp ( Cyprinus carpio L.) was selected as animal model this study. In our study, (45±0.71g) were randomly divided into four groups fed fodder with 50% carbohydrate. The orally administrated 0 mg/kg BW (control group), 200 (low-dose 400 (medium-dose group) 800 (high-dose polysaccharide for two week. At end experiment, serum glucose, TG, MDA...
Tenascin-C (TN-C) is an extracellular matrix glycoprotein markedly upregulated during liver fibrosis. The study performed to explore the role of TN-C growth and activation hepatic stellate cells (HSCs). We found that was accumulated accompanying with HSC activation. Our data on cell migration assay revealed rTN-C treatment enhanced in a dose- time-dependent manner, but did not influence their proliferation. HSCs transfected pTARGET-TN-C overexpression vector displayed increased type I...
As the tissue with highest selenium content in body, occurrence and development of thyroid cancer are closely related to selenoproteins. Selenium-binding protein 1 (SBP1) has been repeatedly implicated several cancers, but its role molecular mechanisms remains largely undefined.The expression SBP1, sodium/iodide symporter (NIS) thioredoxin (TXN) were analyzed clinical samples cell lines. Cell counting kit-8 (CCK-8) tube formation assays used analyze viability cells. Immunofluorescence was...
The Lateolabrax maculatus is an important marine fish in China that can adapt to a wide range of water salinities. gill the main organ involved osmoregulation and this study, cDNA library L. was constructed understand function it adaptation salinity. A total raw data 5.3G base pairs obtained, followed removal low-quality linker DNA sequences yielded 23,038,590 clean reads. After splicing clustering, 31,976 unigenes were obtained. average transcript length 1327 bp N50 2057 bp. In comparisons...
Nineteen polymorphic microsatellites isolated from a partial genomic DNA library of Sarcocheilichthys sinensis enriched for CA repeats were developed. Variability was tested on 48 unrelated individuals collected Jiangsu province, China. Observed heterozygosity ranged 0.200 (Ss236) to 1.00 (Ss223, Ss224), whereas the expected 0.213 (Ss232) 0.939 (Ss224). Shannon's information index 0.405 2.988 Sixteen 19 conformed Hardy–Weinberg equilibrium. These can be used evaluation genetic parameters in...