A5031419410- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Photochromic and Fluorescence Chemistry
- Augmented Reality Applications
- Ovarian function and disorders
- Advancements in Semiconductor Devices and Circuit Design
- Cancer Mechanisms and Therapy
- Gestational Diabetes Research and Management
- Urinary and Genital Oncology Studies
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Synthesis and Properties of Aromatic Compounds
- Anatomy and Medical Technology
- Supramolecular Self-Assembly in Materials
- Pregnancy and preeclampsia studies
- Cancer Research and Treatments
- Aquaculture Nutrition and Growth
- Surgical Simulation and Training
Bengbu Medical College
2024
Second Affiliated Hospital of Soochow University
2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2023-2024
Soochow University
2017-2024
First Affiliated Hospital of Soochow University
2017-2020
China Fishery Machinery and Instrument Research Institute
2018
The aberrant tumor microenvironment (TME), especially immature and leaky vessels, prevents the penetration accumulation of chemotherapeutics results in failure chemotherapy to treat gynecologic cancer. Herein, dexamethasone (Dex), a glucocorticoid steroid used moderate extracellular matrix normalize was enclosed within biocompatible material known as poly(lactic-co-glycolic acid) (PLGA), obtained Dex@PLGA further coated with mouse cervical cancer cell membrane (CM). formulated Dex@PLGA-CM...
Abstract Cervical cancer (CC) is the most prevalent gynecological malignancy occurring in cervix. Long non-coding RNAs (lncRNAs) can act as oncogenes or anti-oncogenes CC development. Here, we investigated functional role and detailed mechanism of lncRNA pyruvate dehydrogenase E1 subunit beta antisense (PDHB-AS) CC. At first, found that PDHB-AS was significantly down-regulated cells. Besides, overexpression repressed cell malignant behaviors. HKF-derived exosomes carried miR-4536-5p to cells...
Countless studies have demonstrated that Circular RNAs (circRNAs) exert vital effects in regulating tumorigenesis of various cancers. CircRNA ZNF609 (circ-ZNF609) has been reported as an oncogene human Nevertheless, its effect cervical cancer (CC) remains to be further explored. RT-qPCR was adopted measure circ-ZNF609, miR-197-3p and E2F6 levels. CC cell proliferation, migration invasion were analyzed via CCK-8 transwell assays. Dual-luciferase reporter assay confirm the interaction between...
Poly (ADP-ribose) polymerase (PARP) inhibitors are a new maintenance therapy option for patients with ovarian cancer (OC). To evaluate the efficacy and influencing factors of novel PARP inhibitor niraparib treatment Chinese advanced OC. In this retrospective multicenter real-world study OC from 15 hospitals throughout China were enrolled. The primary endpoint was progression-free survival (PFS) secondary endpoints included time to discontinuation safety. Least Absolute Shrinkage Selection...
Long noncoding RNAs (lncRNAs) are important regulators in various human diseases. The lncRNA HOXD-AS1 is a tumor promoter ovarian cancer, glioma, and lung but the specific effects of on cervical cancer (CC) chemoresistance remain unclear. Here, level nonmalignant CC tissues as well cells cisplatin-resistant was determined. qRT-PCR indicated that overexpressed cells. Loss-of-function assays showed downregulation expression suppressed targeted miR-130a-3p, gain-of-function miR-130a-3p could...
The induction of supramolecular chirality from achiral polymers has been widely investigated in composite systems consisting a chiral guest, host, and solvents. To further study understand the process transfer solvent or molecules to an polymer backbone side-chain units, alternative is reduce components assembled systems. Herein, azobenzene (Azo)-containing polymers, poly(6-[4-(4-methoxyphenylazo) phenoxy] hexyl methacrylate) (PAzoMA), with different Mns, were synthesized by atom radical...
Background: Polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) can both contribute to adverse maternal neonatal outcomes. There is relatively limited research on the outcomes for women who have a history of PCOS GDM. Our study attempt explore how presence comorbid affects pregnancy in with Methods: was retrospective diagnosed GDM through 75 g oral glucose tolerance test (OGTT) at our hospital from January 1, 2021, December 31, 2022. We divided participants into two...
Background: Cervical cancer (CC) ranks fourth in cancers that resulted death among women, accumulating the attention of researchers. It has been ascertained long noncoding RNAs (lncRNAs) are crucial players pathological processes a host cancers. And, SNHG7 reported to enhance occurrence various cancers; however, its function CC sustains obscure. Aim Study: This study explored and further investigates specific molecular mechanism regulating CC. Methods: The levels cells were reflected by...
Purpose: Cervical cancer is one of the most fatal diseases among women in under-developed countries.To improve cervical treatment, discovery new targets needed.In this study, we investigated expression NUP210, miR-22, and Fas tissues their functions cell cycle regulation.Materials Methods: We detected compared levels with paired normal using immunohistochemistry, Western blot, real-time quantitative polymerase chain reaction.NUP210 was knocked down HeLa cells via lentivirus, followed by...
CircMCTP2 is a novel circRNA, which associated with various kinds of malignant tumors progression, such as gastric cancer. However, the function circMCTP2 in bladder carcinoma (BC) has no idea. The purpose this study was tantamount to functionally dissect progression BC. In our study, expression strongly increased BC tissues and cell lines. High predicted poor prognosis patients. deficiency impaired growth, migration well invasive ability lines (J82 T24). vivo, cut tumor growth rates weight....
Monocular endoscope-based reconstruction of dynamic 3D surgical fields is beneficial for both intraoperative manual/robotic manipulation and post-operative skills training. However, the natural characteristics tissue deformations with instruments blood obscuration bring great challenges to scene awareness, especially under sparse viewpoints limited by laparoscopic movements. In this work, we propose Endo-4SRF, an effective Neural Radiance Field (NeRF)-based method that can reconstruct...
To explore the health information avoidance behaviors and influencing factors of cancer patients, to construct a structural equation model analyze mediating roles self-efficacy negative emotions in process generating patients.
5551 Background: Niraparib has significantly extended PFS as 1st-L MT OC in PRIMA/PRIME. Due to the more complex treatment and status of patients (pts) clinal practice, real-world data is needed verify efficacy safety Niraparib. Meanwhile, exploring link between clinical characters PFS, may establish a model predict benefits. Methods: This retrospective multicentric study recruiting pts received from fourteen hospitals throughout China Jan. 2019 Dec. 2021. The database lock-time was on 31st,...