Computed tomographic (CT) scans and magnetic resonance (MR) images obtained in 24 patients with cervical lymphadenopathy were retrospectively blindly evaluated by two readers for the presence of central nodal necrosis (CNN) extracapsular spread (ENS). The CT studies all enhanced, MR short repetition time (TR)/echo (TE), long TR/double echo, enhanced TR/TE fat-suppressed sequences. Each imaging sequence was interpreted separately then collectively. Sixty lymph nodes identified CT. Sensitivity...

Occult cerebral vascular malformations (OCVMs) have characteristic appearances on high-field magnetic resonance (MR) images. These consist of circumscribed regions low intensity, most prominent T2-weighted images and representing hemosiderin deposits. Interspersed within these lesions are multiple areas various signal intensity patterns, which correspond to hematomas in different stages evolution fibrous containing calcium as well hemosiderin. Forty-six were found 19 patients (34...

Anisotropy of water diffusion in axon tracts, as determined by diffusion-weighted MRI, has been assumed to reflect the restriction across membranes. Reduction this anisotropy interpreted degeneration axons. These interpretations are based primarily on a priori reasoning that had little empirical validation. We used experimental advantages sea lamprey spinal cord, which contains several very large axons, determine whether intraaxonal is isotropic and attributable mobility surface Through...

Until the development of magnetic resonance (MR) imaging there was no nondestructive technique for monitoring pathologic response to acute spinal cord trauma. The characteristic findings hemorrhage, necrosis, and edema have been well described in animal models. We used a 1.4-T, system study contusions rats. Contusions were induced by means extradural aneurysm clip compression, performed 3-5 hours after injury with short long spin-echo (SE) sequences. Animals killed immediately imaging, gross...

Magnetic resonance imaging has previously demonstrated its potential for indirectly mapping myelin density, either by relaxometric detection of water or magnetization transfer. Here, we investigated whether can be detected and possibly quantified directly. We identified the spectrum in spinal cord situ as well lipids extracted via a sucrose gradient method, spectral properties. High-resolution solution NMR spectroscopy showed extract composition to agreement with myelin’s known chemical...

Twelve patients with 15 separate, spontaneously hemorrhagic, intracranial malignant lesions (seven primary gliomas, eight metastatic lesions) were examined spin-echo magnetic resonance imaging at 1.5 T, and computed tomography. The signal intensity patterns of these lesions, as seen on both short repetition time (TR)/short echo (TE) long-TR/long-TE pulse sequences, compared the previously described appearance T non-neoplastic intracerebral hematomas. images hemorrhagic malignancies showed...

Abstract Apparent diffusion coefficients (ADC) were measured in a rat spinal cord weight‐drop injury model. After sacrifice, the cords fixed situ and excised for MR imaging ADC measurement. Diffusion is anisotropic normal gray white matter. There significant decreases ADCs along longitudinal axis of injured increases transverse to cord. Injured segments demonstrated reductions anisotropy was completely isotropic at epicenter injury. Significant observed portions which appeared on...

Twenty-five newly diagnosed intracranial meningiomas were evaluated with magnetic resonance (MR) imaging at 1.5 T, and findings correlated those of computed tomography (CT), angiography, tumor histology. Meningiomas generally hypointense on T1-weighted images hyperintense T2-weighted relative to cerebral white matter. In comparison the cortex, they or isointense images. A heterogeneous texture produced by vascularity, calcifications, cystic foci, an intrinsic speckled mottled pattern was...

Following spinal cord injury, diffusion MRI (DWI) has been shown to detect injury and functionally significant neuroprotection following treatment that otherwise would go undetected with conventional MRI. The underlying histologic correlates directional apparent coefficients (ADC) obtained DWI have not determined, however, we address this issue by directly correlating ADC values corresponding axon morphometry in the normal rat cervical cord. transverse (perpendicular) longitudinal (parallel)...

High-field magnetic resonance (MR) imaging was performed in three patients with clinically diagnosed acute disseminated encephalomyelitis (ADEM). Contrast enhanced CT normal all cases. Magnetic demonstrated multiple foci of demyelination the brain stem, cerebrum, and cerebellum. Lesions were characteristic, that they (a) relatively few number, (b) frequently present stem posterior fossa, (c) non-hemorrhagic, (d) asymmetric, (e) easily correlated clinical symptoms signs. Follow-up MR one...

To investigate the correlation between diffusional anisotropy and developmental changes in anatomy, which include myelination, central peripheral nerves an animal model by using quantitative diffusion magnetic resonance (MR) imaging electron microscopy.In vivo transverse longitudinal apparent coefficients (ADCs) of optic trigeminal 2-10-week-old rats were measured with MR imaging. Then animals sacrificed at each time point, sections studied nerve, ADC parallel to neurofibers increased...

Two patients with surgically and angiographically proved partially thrombosed giant aneurysms of the middle cerebral artery were studied computed tomography (CT) magnetic resonance (MR) imaging. MR histopathologic findings correlated. The central location methemoglobin, its high intensity (surrounding patent lumen, seen as signal void), in is directly opposite initial peripheral appearance methemoglobin extra-aneurysmal intracerebral hematomas. More peripherally, portion lumen layered...

Ten patients with intracerebral metastases from malignant melanoma were evaluated magnetic resonance (MR) imaging performed at 1.5 T using spin-echo techniques. On the basis of histopathologic findings in three 10 cases and CT appearances all cases, patterns identified on analysis MR signal intensities both short repetition time/echo time (TR/TE) long TR/TE scans. In comparison to normal cortex, nonhemorrhagic melanotic appeared markedly hyperintense images isointense, mildly hypointense...

Preclinical evidence indicates that iron plays a key role in mediating neuronal injury and edema formation after intracerebral hemorrhage (ICH). However, the clinical of patients with ICH has not been well studied. We undertook this exploratory study to investigate association serum ferritin, as an indicator body load, perihematoma ICH.We retrospectively reviewed prospectively-collected laboratory data from 23 consecutive acute spontaneous who had CT scan ferritin checked on admission,...

Background and Purpose— A decrease in fractional anisotropy (FA) of the ipsilesional corticospinal tract (CST) distal to stroke lesions subacute (eg, 30 days) chronic phase has been correlated with poor motor outcomes, but it is unclear whether FA values obtained within acute (here defined as 80 hours after onset) can predict later outcome. Methods— Fifty-eight patients underwent an assessment impairment at 3 months using upper extremity Fugl-Meyer assessment. values, onset, were determined...

Primary CNS malignancies are responsible for approximately 12,000 deaths annually in the United States. There has been little change outcome adults with malignant brain tumors over past few decades, despite improvements surgical techniques and advances radiation therapy. These uniformly fatal one to two years after diagnosis. The morbidity mortality of this disease arise from effects a locally invasive, non-metastasizing lesion. patients may suffer seizures, paralysis, incoordination,...

Agenesis of the corpus callosum is a complex malformation brain that has been associated with varying degrees limbic system maldevelopment. We retrospectively reviewed records 11 patients callosal agenesis (seven total, four partial) who underwent magnetic resonance (MR) imaging, particular attention to malformations system. Comparison was made selected images from MR examinations healthy volunteers and necropsy specimens other agenesis. Ten demonstrated anomalies (severe motion artifact...