A5041434797- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Spine and Intervertebral Disc Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Stroke Rehabilitation and Recovery
- Neurobiology of Language and Bilingualism
- Neurosurgical Procedures and Complications
- Botulinum Toxin and Related Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Wnt/β-catenin signaling in development and cancer
- Transcranial Magnetic Stimulation Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Bone and Joint Diseases
- COVID-19 epidemiological studies
- Musculoskeletal pain and rehabilitation
- Orthopedic Infections and Treatments
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Heat shock proteins research
- Neuroscience and Neuropharmacology Research
- RNA and protein synthesis mechanisms
- Peripheral Nerve Disorders
- COVID-19 Impact on Reproduction
- Cellular and Composite Structures
Johns Hopkins University
2024
University of Virginia Health System
2024
Thomas Jefferson University
2021-2023
Rothman Orthopaedics
2021-2023
Rothman Institute
2021-2023
Philadelphia University
2022
Harvard University
2013-2021
Beth Israel Deaconess Medical Center
2013-2021
University of California, San Diego
2021
Western University
2020
Objective The aim of this work was to investigate whether an imaging measure corticospinal tract (CST) injury in the acute phase can predict motor outcome at 3 months comparison clinical assessment initial impairment. Methods A two‐site prospective cohort study followed up a group first‐ever ischemic stroke patients using Upper‐Extremity Fugl‐Meyer (UE‐FM) Scale impairment and months. weighted CST lesion load (wCST‐LL) calculated by overlaying patient's map on magnetic resonance with...
Background and Purpose— A decrease in fractional anisotropy (FA) of the ipsilesional corticospinal tract (CST) distal to stroke lesions subacute (eg, 30 days) chronic phase has been correlated with poor motor outcomes, but it is unclear whether FA values obtained within acute (here defined as 80 hours after onset) can predict later outcome. Methods— Fifty-eight patients underwent an assessment impairment at 3 months using upper extremity Fugl-Meyer assessment. values, onset, were determined...
There is a need to identify biomarkers that predict degree of chronic speech fluency/language impairment and potential for improvement after stroke. We previously showed the Arcuate Fasciculus lesion load (AF-LL), combined variable site size, predicted fluency in patients with aphasia. In current study, we compared loads such structural map (i.e., AF-LL) those functional [i.e., gray matter (fGM-LL)] their ability naming performance large group patients. The fGM was constructed from brain...
<h3>Objective:</h3> We sought to determine via a cross-sectional study the contribution of (1) right hemisphere9s speech-relevant white matter regions and (2) interhemispheric connectivity speech fluency in chronic phase left hemisphere stroke with aphasia. <h3>Methods:</h3> Fractional anisotropy (FA) underlying middle temporal gyrus (MTG), precentral (PreCG), pars opercularis (IFGop) triangularis (IFGtri) inferior frontal gyrus, corpus callosum (CC) was correlated measures. A region within...
Abstract Objectives Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual unknown and decisions are currently made on subjective basis. Predictors response to specific therapies would guide the type therapy most appropriate for patient. Although lesion topography strong predictor upper limb response, walking involves more distributed functions. Earlier studies that assessed cortico‐spinal tract (CST) were...
Spiral ganglion neurons (SGNs) carry sound information from the cochlea to hindbrain, and innervate either inner or outer hair cells (OHCs). Type II SGNs (SGNIIs) extend peripheral afferents towards OHCs, which make a characteristic 90-degree turn cochlear base multiple OHCs. It has been shown that Planar Cell Polarity (PCP) pathway acts non-autonomously in epithelium guide SGNII afferent turning. However, underlying mechanisms are unknown. Here, we show PCP signaling regulates junctional...
Retrospective cohort.To compare health-related quality of life (HRQoL) outcomes between approach techniques for the treatment multilevel degenerative cervical myelopathy (DCM).Both anterior and posterior approaches surgical are successful in myelopathy. However, optimal has yet to be determined, especially disease, as different have separate complication profiles potentially impacts on HRQoL metrics.Retrospective review a prospectively managed single institution database patient-reported...
Ischemic stroke is a complex and devastating event characterized by cell death resulting from transient or permanent arterial occlusion. Astrocytic connexin43 (Cx43) gap junction (GJ) proteins have been reported to impact neuronal survival in ischemic conditions. Consequently, Cx43 could be potential target for therapeutic approaches stroke. We examined the effect of danegaptide (ZP1609), an antiarrhythmic dipeptide that specifically enhances GJ conductance, two different rodent models. In...
Background: Hematoma volume (HV) is a powerful determinant of outcome after intracerebral hemorrhage. We examined whether the effect iron chelator, deferoxamine, on functional varied depending HV in i-DEF trial (Intracerebral Hemorrhage Deferoxamine). Methods: A post hoc analysis trial; participants were classified according to baseline (small <10 mL, moderate 10–30 and large >30 mL). Favorable was defined as modified Rankin Scale score 0–2 at day-180; secondarily day-90. Logistic...
We studied the T cell response to SARS-CoV-2 spike and non-spike peptide epitopes in eight convalescent pregnant women together with immune monitoring that included innate tolerogenic dendritic populations important maintain immunological mother/fetus interface address a potential risk for antiviral cellular outcome of pregnancy. Four subjects had pre-existing chronic inflammatory conditions could have potentially affected SARS-CoV-2-specific response. Seven responded peptides differences...
Introduction: As an increasing number of lumbar fusion procedures are being conducted at specialty hospitals and surgery centers, appropriate patient selection risk stratification is critical to minimizing transfers. Postoperative cardiac arrhythmia has been linked worse outcomes a common cause transfer. Therefore, we created calculator predict patient's likelihood developing new-onset postoperative after spinal fusion, which may improve preoperative facility selection. Methods: A...
Background and Purpose: Fewer women than men tend to be enrolled in clinical trials of intracerebral hemorrhage. It is unclear whether this reflects lower prevalence hemorrhage women, selection bias, or poor recruitment efforts. We undertook study examine differences between the reasons for exclusion from iDEF trial (Intracerebral Hemorrhage Deferoxamine). Methods: The screen failure log included 29 different exclusion. Chi-square statistics were used evaluate women. Results: A total 38.2%...
Our sense of hearing is critically dependent on the spiral ganglion neurons (SGNs) that connect sound receptors in organ Corti (OC) to cochlear nuclei hindbrain. Type I SGNs innervate inner hair cells (IHCs) transmit signals, while type II (SGNIIs) outer (OHCs) detect moderate-to-intense sound. During development, SGNII afferents make a characteristic 90-degree turn toward base cochlea and multiple OHCs. It has been shown Planar Cell Polarity (PCP) pathway acts non-autonomously mediate...
The function of neuronal circuits, and its perturbation by psychoactive molecules or disease-associated genetic variants, is governed the interplay between synapse activity synaptic protein localization synthesis across a heterogeneous population. Here, we combine in situ measurement multiprotein compositions activation states, calcium traces glutamate spiking, local translation specific genes, same individual synapses. We demonstrate how this high-dimensional data enables identification...
The COVID-19 pandemic may have disproportionally impacted vulnerable groups such as people who inject drugs (PWID) through reduced healthcare services well social changes from mitigation measures. Understanding how the and associated strategies subsequently changed trajectory of hepatitis C virus (HCV) HIV transmission is critical to estimating disease burdens, identifying outbreak risk, developing informed intervention strategies.
Objective: To evaluate the reasons for transfer as well 90-day outcomes of patients who were transferred from a high-volume orthopedic specialty hospital (OSH) following elective spine surgery. Materials and Methods: All admitted to single OSH surgery 2014 2021 retrospectively identified. Ninety-day complications, readmissions, revisions, mortality events collected 3:1 propensity match was conducted. Results: Thirty-five (1.5%) 2351 transferred, most commonly arrhythmia ( n = 7; 20%)....
We previously showed that a combined variable of lesion site and size, the Arcuate Fasciculus load (AF-LL), predicted speech fluency in chronic aphasic patients. In current study, we compare correlations between naming measures with two markers large group patients: established structural marker (i.e., AF-LL) new functional grey matter (fGM-LL)). fGM-LL was constructed from brain imaging overt speaking tasks twelve healthy elderly control participants. High-resolution images were acquired to...
Background: A decrease in fractional anisotropy (FA) of the ipsilesional corticospinal tract (CST) distal to ischemic stroke lesions chronic patients has been associated with poor motor outcome, but acute phase no clear FA trends have observed or used make outcome predictions. Methods: This study followed 40 first-ever stroke, measuring impairment Upper Extremity Fugl-Meyer (UE-FM) acutely and at 3 months. Images obtained <3 days after including FA, were overlaid a probabilistic CST (blue...
Introduction: Lesion load of the Corticospinal Tract (CST-LL) can predict 64% variance in 3-months outcome acute stroke patients. Voxel-based lesion symptom mapping (VLSM) studies have revealed brain voxels associated with motor impairment. A combined VLSM- CST-LL approach may give particular weight to that are both part an impairment map and descending tracts. Hypothesis: VLSM-wCST-LL model better than weighted alone. Methods: We derived VLSM from a group 50 chronic patients variable...