A5087275287- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ion Channels and Receptors
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Galectins and Cancer Biology
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Colorectal Cancer Surgical Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Toxoplasma gondii Research Studies
- Endometrial and Cervical Cancer Treatments
- Cell Adhesion Molecules Research
- Carcinogens and Genotoxicity Assessment
Blackboard (United States)
2024
Guangxi Medical University
2015-2023
Tumor Hospital of Guangxi Medical University
2014-2020
Abstract Growing evidence has revealed that long noncoding RNAs (lncRNAs) have an important impact on tumorigenesis and tumor progression via a mechanism involving competing endogenous (ceRNAs). However, their use in predicting the survival of patient with hepatocellular carcinoma (HCC) remains unclear. The aim this study was to develop novel lncRNA expression–based risk score system accurately predict patients HCC. In our study, using expression profiles downloaded from Cancer Genome Atlas...
Patients with hepatocellular carcinoma (HCC) have different prognoses depending on whether or not they also fibrosis. Since long non‑coding RNAs (lncRNAs) affect tumor formation and progression, the present study aimed to investigate their expression might help predict survival of patients HCC. Expression profiles downloaded from The Cancer Genome Atlas database were examined identify lncRNAs differentially expressed (DElncRNAs) between HCC without These DElncRNAs then used develop a risk...
Objective: This study aims to explore the roles of long non-coding RNAs (lncRNAs) for predicting survival in hepatocellular carcinoma (HCC) patients with cirrhosis. Methods: A set lncRNAs differentially expressed between HCC or without cirrhosis was identified using expression profiles The Cancer Genome Atlas database, and these were screened their risk scoring system predict recurrence-free (RFS) overall (OS). Predictive ability systems confirmed uni- multivariate Cox analyses while...
Distant metastasis remains the primary cause of treatment failure and suggests a poor prognosis in nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) is critical cellular process for initiating tumor invasion remote metastasis. Our previous study showed that blockage stromal interaction molecule 1 (STIM1)-mediated Ca2+ signaling blunts Epstein-Barr virus (EBV)-promoted cell migration inhibits dissemination lymphatic NPC cells. However, upstream pathway regulates STIM1...
Aberrant modulation of store-operated calcium ions (Ca(2+)) entry promotes the progression human malignancies. Previously, we reported that blockage Ca(2+) inhibited epidermal growth factor (EGF)-stimulated migration and distant metastasis in nasopharyngeal carcinoma (NPC) cells. However, effects pharmacological blocker on other signaling-regulated malignant characteristics NPC cells remained poorly understood.We examined SKF96365, an inhibitor channel, EGF-launched signaling two cell lines....
Epstein-Barr virus (EBV) actively contributes to the pathological process of nasopharyngeal carcinoma (NPC) by enabling NPC cells acquire various capacities required for their malignant biological actions. Our earlier works demonstrated that EBV-encoded latent membrane protein 1 (LMP1) enhanced vascular endothelial growth factor (VEGF)-mediated angiogenesis boosting store-operated Ca2+ entry (SOCE) upon extracellular epidermal (EGF) stimulation. However, antagonistic effects SOCE blockage on...
Almost all the patients with hepatocellular carcinoma (HCC) at advanced stage experience pathological changes of chronic liver cirrhosis, which generally leads to moderate ascites. Recognition novel biomarkers in malignant ascites could be favorable for establishing a diagnosis HCC ascites, and even predicting prognosis, such as risk distant metastasis. To distinguish proteomic profiles from those nonmalignant an iTRAQ pipeline was built up analyze differentially distributed proteins (n=10)...
Increasing evidence suggests that long non-coding RNAs (lncRNAs) serve a crucial role in predicting prognosis for hepatocellular carcinoma (HCC). However, prognostic performance may not be the same alcohol‑related HCC. The aim of present study was to screen prognosis‑associated lncRNAs and construct risk scoring system expression profiles 113 patients with HCC 224 non‑alcohol‑related were obtained from Cancer Genome Atlas (TCGA) database screened differentially expressed lncRNAs. Cox...
Epstein-Barr virus (EBV) promotes tumor angiogenesis in nasopharyngeal carcinoma (NPC) by activating store-operated Ca2+ entry. Since such entry has been linked to stromal interaction molecule 1 (STIM1), we examined whether the acts via STIM1-dependent signaling promote NPC. STIM1 expression was detected NPC cell lines HK1 and CNE2 that were negative or positive for EBV. knocked down EBV-positive cells using recombinant lentivirus, then cytosolic levels measured based on fluorescence...
The aim of the present analysis was to compare efficacy and safety profile S‑1‑based chemotherapy (SBCT) versus capecitabine‑based (CBCT) for advanced gastric cancer (AGC) colorectal (ACRC). A meta‑analysis performed, which included eligible randomized controlled trials (RCTs) that were identified using RevMan 5.1.0 software. total 1,064 patients from 11 RCTs, comprising 527 in SBCT group 537 CBCT group, analysis. For AGC, overall survival (OS) [hazard ratio (HR), 0.98; 95% confidence...
Abstract Background Stromal interaction molecule 1 (STIM1)-mediated Ca 2+ signaling regulates tumor angiogenesis in nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-related human malignancy. However, the mechanism by which STIM1 modulates endothelial functional phenotypes contributing to remains elusive. Methods We explored intercellular communication via exosomal biomolecules released EBV-infected NPC cells and delivered (ECs). The cell-derived exosomes were isolated differential...
Conflicting results have been obtained regarding the association between X-ray repair cross complementation group 1 (XRCC1) and susceptibility to hepatocellular carcinoma (HCC). In this study, associations HCC three polymorphisms (Arg194Trp, Arg280His, Arg399Gln) were evaluated using a meta-analysis approach. PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang standard database systematically searched identify all relevant case-control studies...