A5085981285- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer Treatment and Pharmacology
- Reconstructive Surgery and Microvascular Techniques
- Liver Disease Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cardiac tumors and thrombi
- Surgical site infection prevention
- Endometrial and Cervical Cancer Treatments
- Chemotherapy-induced organ toxicity mitigation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- Neutropenia and Cancer Infections
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Health, Medicine and Society
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Metal complexes synthesis and properties
- Healthcare Systems and Practices
- HER2/EGFR in Cancer Research
Princess Margaret Cancer Centre
2024
Hôpital Saint-Vincent-de-Paul
2024
Inserm
1976-2018
Centre Hospitalier de l’Université de Montréal
2011-2017
Université de Montréal
2017
Centre Oscar Lambret
2006-2015
Institut de Recherche et de Documentation en Économie de la Santé
2013
University of Wyoming
2013
Centre Eugène Marquis
2007-2012
Centre Hospitalier Universitaire de Lille
1998-2012
Purpose The objective of this phase II trial was to assess the efficacy and toxicity weekly paclitaxel for patients with metastatic or unresectable angiosarcoma. Patients Methods Thirty were entered onto study from April 2005 through October 2006. Paclitaxel administered intravenously as a 60-minute infusion at dose 80 mg/m 2 on days 1, 8, 15 4-week cycle. primary end point nonprogression rate after two cycles. Results progression-free survival rates 4 months 74% 45%, respectively. With...
The salivary cortisol concentration is an excellent indicator of the plasma free concentration. To establish its normal and pathological ranges, concentrations were measured in 101 adults, 18 patients with Cushing's syndrome, 21 adrenal insufficiency. subjects had a mean (+/- SEM) 15.5 +/- 0.8 nmol/L (range, 10.2-27.3) at 0800 h 3.9 0.2 2.2-4.1) 2000 (n = 20). value 60 min after ACTH administration 58 was 52.2 2.2 23.5-99.4), it 1.4 1.1 1.6-3) 23 given 1 mg dexamethasone 8 earlier. In...
Abstract Background. Angiosarcomas account for <2% of all soft tissue sarcomas. This subtype is one the most aggressive forms sarcoma. The prognosis angiosarcoma patients in advanced phase remains poor with current cytotoxic agents (progression-free survival [PFS] time ∼4 months and overall [OS] ∼8 months). We investigated antitumor activity sorafenib metastatic or angiosarcomas a II trial. Methods. conducted stratified primary endpoint was progression-free rate (PFR) at 9 according...
BACKGROUND There is no standard treatment for progressive epithelioid hemangioendothelioma (EHE). To investigate the significant vascularization of EHE, activity/toxicity sorafenib in patients with EHE was explored. METHODS In this multicenter, 1‐stage, phase 2 trial (800 mg daily), primary endpoint, which chosen by default, 9‐month progression‐free rate. All had documented disease at time study entry. RESULTS Fifteen were enrolled between June 2009 and February 2011. The median age 57 years...
The prolongation of life expectancy results in an increasing number malignant neoplasms occurring the elderly population. For a long time these patients were not considered good candidates to receive aggressive therapy and probably inadequately treated many instances.To assess outcome older than 74 years who had head neck squamous cell carcinoma.In our database 4610 consecutive with carcinomas evaluated at Centre Oscar Lambret, Northern France Comprehensive Cancer Center, Lille, over 10-year...
The goal of this prospective study is to determine risk factors for wound infections (WI) patients with head and neck cancer who underwent surgical procedure opening upper aerodigestive tract mucosa.One hundred sixty-five consecutive procedures were studied at Oscar Lambret Cancer Center within a 24-month interval. Twenty-five variables recorded each patient. Statistical evaluation used Chi2 test analysis (categorical data) Mann-Whitney (continuous variables).The overall rate WI was 41.8%....
Abstract A common property of allergens is their potential to generate type 2 cytokine responses. To understand the mechanisms involved in this phenomenon, we have evaluated polarizing a major allergen, Dermatophagoides pteronyssinus 1 (Der p 1), an heterologous immunization system using glutathione S-transferase parasite Schistosoma mansoni (Sm28-GST) as immunogen. In previous studies, showed that with Sm28-GST emulsified CFA induced nonpolarized immune response. contrast, when alum was...
Objectives: Squamous cell carcinoma (SCC) in young people is rare and the literature confusing. This study was carried out to assess demographics, clinical features, treatment outcome a cohort of patients aged 35 years or less with SCC oral tongue (SCCOT). Patients methods: multicenter retrospective study. Fifty-two treated between 1990 2000 were identified. Descriptive statistics analyzed demographic tumor variables. Results: The WHO performance status excellent for all patients....
The toxicities and tissue uptake of cisplatin (CDDP) carboplatin (CBDCA) vary largely according to the time injection a single dose. Repeated dosages may alter mechanisms involved with such circadian-dependent toxicity. Weekly i.v. injections CDDP (5 mg/kg) or CBDCA (50 were given over 2 months 288 male B6D2F1 mice standardized by an alternation 12 hr light darkness at any one three circadian dosing times (0, 8 16 after onset--HALO). Survival; body weight; complete blood cell counts;...
Abstract Background. In the north of France, a delay in primary consultation has been noted among patients with head and neck cancer. This group is often correlated lower socioeconomic status lack medical information. Therefore, choice to seek influenced by symptoms such as pain change size tumors neck. We studied this seeking consultation, focusing on psychosocial variables professional social background, involvement spouse/partner, presence anxiety depression. Methods. Two rating scales...
Preclinical findings suggest that imatinib mesylate (IM) and metronomic cyclophosphamide (MC) combination provides synergistic antiangiogenic activity on both pericytes endothelial cells. We have designed a 3+3 dose-escalating phase I trial with fixed dose of MC (50 mg two times daily) plus IM (400 per day; 300 400 daily). Enrolled patients had IM- sutininib-refractory advanced gastrointestinal stromal tumours (GIST) (n=17), chordoma (n=7) mucosal melanoma (n=2). Dose-limiting toxicities...