- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Neurological disorders and treatments
- Plant Molecular Biology Research
- Ophthalmology and Visual Impairment Studies
- Pharmacological Effects and Toxicity Studies
- Infective Endocarditis Diagnosis and Management
- Fetal and Pediatric Neurological Disorders
- Orthopedic Infections and Treatments
- Plant Stress Responses and Tolerance
- Plant-Microbe Interactions and Immunity
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Pluripotent Stem Cells Research
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
- Plant Gene Expression Analysis
- Ocular Infections and Treatments
- Oropharyngeal Anatomy and Pathologies
- Gastrointestinal Bleeding Diagnosis and Treatment
- DNA Repair Mechanisms
- Ocular Oncology and Treatments
- Greenhouse Technology and Climate Control
Anyang Eye Hospital
2023
Seoul National University
2022
Rural Development Administration
2010-2022
National Academy of Agricultural Science
2010-2022
Yonsei University
1994-2016
Severance Hospital
2006-2013
Catholic University of Korea
2004-2009
Nune Eye Hospital
2007
Seoul St. Mary's Hospital
2004
National Institute of Agricultural Science and Technology
2000
Abstract Plants have evolved sophisticated defense systems to enhance drought tolerance. These include the microRNA (miRNA) group of small noncoding RNAs that act as post‐transcriptional regulators; however, details mechanisms by which they confer tolerance are not well understood. Here, we show osa‐MIR171f , a member osa ‐ MIR171 gene family, is mainly expressed in response stress and regulates transcript levels SCARECROW‐LIKE6‐I ( SCL6‐I ) SCL6‐II rice Oryza sativa ). The SCL6 genes known...
Sound vibration (SV), a mechanical stimulus, can trigger various molecular and physiological changes in plants like gene expression, hormonal modulation, induced antioxidant activity calcium spiking. It also alters the seed germination growth of plants. In this study, we investigated effects SV on resistance Arabidopsis thaliana against Botrytis cinerea infection. The microarray analysis was performed infected pre-exposed to 1000 Hertz with 100 decibels. Broadly, transcriptomic revealed...
Summary: Purpose: To investigate the prognosis related to antiepileptic drug (AED) discontinuation after successful surgery for intractable temporal lobe epilepsy. Methods: The clinical courses lobectomies (TLs) were retrospectively analyzed in 88 consecutive patients. All patients had TLs as only surgical procedure, and they been followed up longer than 3 years. AED was attempted if patient seizure free without aura ≥1 year during follow‐up period. Results: Sixty‐six (75%) achieved complete...
Cell transplantation has been suggested as an alternative therapy for temporal lobe epilepsy (TLE) because this can suppress spontaneous recurrent seizures in animal models. To evaluate the therapeutic potential of human neural stem/progenitor cells (huNSPCs) treating TLE, we transplanted huNSPCs, derived from aborted fetal telencephalon at 13 weeks gestation and expanded culture neurospheres over a long time period, into epileptic hippocampus fully kindled pilocarpine-treated adult rats...
The present study describes bio-polymerase chain reaction (PCR) assays to detect bacterial leaf blight caused by Xanthomonas oryzae pv. in rice. Successful control of X. oryzae. requires a specific and reliable diagnostic tool. However, other pathovars are detected currently available molecular serological methods. In this study, SYBR Green real-time conventional PCR primer sets were designed based on an rhs family gene KACC10331 because these genes structurally diverse. specificity the...
A 15-yr-old boy was admitted to the Neurology Department on May 18, 2005, with a 3-day history of headache and 2 days generalized petechiae, nausea, vomiting (Table 1).His past medical unremarkable.On admission, his oral temperature 36.9℃,heart rate 93 beats/ min, blood pressure 125/82 mmHg.He alert complained about neck stiffness.There were no motor or sensory deficits, rest physical examination
Hypertrophic cranial pachymeningitis (HCP) is a rare inflammatory disease of unknown origin in which recurrence frequently observed spite the initial response to steroid therapy. Three patients, 1 man and 2 women, aged 63, 66, 67 years, with severe intractable headache were evaluated by brain MRI. All patients initially given prednisolone (60 mg/day, oral) or dexamethasone (20 i.v.), followed long-term (at least year) azathioprine follow-up laboratory tests MRI study, completed 2-year...
We studied the clinical characteristics, location of epileptogenic regions, and surgical outcomes in 18 patients with intractable epilepsy associated previous CNS infections. All underwent an extensive presurgical evaluation 11 had intracranial EEG monitoring. On basis evaluation, epileptic regions were localized to mesial temporal (n = 12) neocortical 6) regions. The age time infection was significantly younger latent period non-febrile seizures after longer lobe (MTLE). MRI showed...
This study identifies 2,617 candidate genes related to anthocyanin biosynthesis in rice using microarray analysis and a newly developed maximum boundary range algorithm. Three seed developmental stages were examined white cultivar two black Dissociation insertion mutants. The resultant 235 transcription factor found be associated with classified into nine groups. It is compared the by 593 from among clusters of COGs functions. Total 32 expressed commonly. Among these, 9 unknown hypothetical...
Summary: Purpose: To examine whether the distribution of interictal epileptiform discharges (IEDs) recorded from foramen ovale electrodes (FOEs) correlates with metabolite levels in medial structures temporal lobes patients mesial lobe epilepsy (MTLE). Methods: We studied 34 MTLE. The lateralization ratio IEDs was calculated after counting FOEs during prolonged video‐EEG monitoring. Metabolite between N ‐acetylaspartate (NAA) and creatine (Cr) each structure. correlation metabolic evaluated....
Cryptococcal meningitis is a rare complication of systemic lupus erythematosus (SLE).The nonspecific neurologic findings associated with this infection delays accurate diagnosis because initial neuropsychiatric manifestations SLE are in instances indistinguishable from that crytococcal meningitis.We report case cryptococcal presenting unilateral sixth cranial nerve palsy male patient SLE, which was successfully treated antifungal agents.
Unilateral or bilateral lateral rectus resection is commonly performed for the correction of residual esotropia, but few results have been reported. Twenty-eight patients with esotropia underwent (BLR) resection. Six months after operation (n = 25), there were 17 (68%) successful cases, 7 (28%) cases undercorrection, and 1 (4%) case overcorrection. The success rate at 24th postoperative month 11) was 72.7%. infantile 18) higher than that acquired 7) 6th (p 0.156). not significantly affected...
In cultivated plants, shoot morphology is an important factor that influences crop economic value. However, the effects of gene expression patterns on are not clearly understood. this study, molecular mechanism behind (including leaf, stem, and node) was analyzed using RNA sequencing to compare weedy (creeper) cultivar (stand) growth types obtained in F7 derived from a cross wild soybeans. A total 12,513 (in leaves), 14,255 stems), 11,850 nodes) differentially expressed genes were identified...
Department of Neurology*, Seoul National University Bundang Hospital, Seongnam; Neurology†, Boramae Seoul; Neurology‡, Yonsei Severance Social and Preventive Medicine§, Sungkyunkwan School Medicine, Suwon, Korea Background: Creutzfeldt-Jakob disease (CJD) is very rare human prion disease. But, neurologists take a key role in diagnosis, surveillance management the cases because its complexity difficulty diagnosis The aim this study to investigate level awareness preparedness Korean on...
This study estimated the overall incidence of iatrogenic Creutzfeldt-Jakob disease (iCJD) based on dura graft cases in Korea using a mathematical model.We number annual grafts performed between 1980 and 1995 by applying proportion recorded Health Insurance Review Agency claim dataset to nationwide neurosurgery cases. The distribution incubation period was assumed fall under Weibull with density function or log-logistic function.The total procedures from be 263,945, among those operations,...
Intra-carotid urokinase (UK) infusion in 20 patients with acute internal carotid artery (ICA) territorial ischemic stroke achieved immediate recanalization 45% and the clinical outcome was superior to that of without recanalization. The procedure most effective smaller arterial occlusions: 7 10 MCA branch occlusions (M2 M4) compared only 2 distal ICA or M1 occlusions, which should be an important issue for critical evaluation efficacy thrombolytic therapy (TT). Hemorrhagic transformation...
Purpose: To evaluate the clinical usefulness of intravenous propofol and fentanyl anesthesia during adjustable strabismus surgery, to investigate effectiveness safety assess degree patient satisfaction. Methods: Patients over 15 years age who underwent surgery using sedation from January 2003 December 2004 were included in this study. At beginning operation, patients received an bolus 1 1.5 mg/kg. Propofol was injected into a vein continuously operation keep blood concentration within...