A5100398619- Chronic Myeloid Leukemia Treatments
- Autophagy in Disease and Therapy
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Genomics, phytochemicals, and oxidative stress
- Acute Lymphoblastic Leukemia research
- Science, Research, and Medicine
- Dietary Effects on Health
- Mathematical Biology Tumor Growth
- Oral health in cancer treatment
- Uterine Myomas and Treatments
- Infectious Aortic and Vascular Conditions
- Histone Deacetylase Inhibitors Research
- HIV/AIDS drug development and treatment
- Colorectal and Anal Carcinomas
- Water Treatment and Disinfection
- HER2/EGFR in Cancer Research
- Ferroptosis and cancer prognosis
- Circadian rhythm and melatonin
- Ocular Oncology and Treatments
- Aortic aneurysm repair treatments
- Endometrial and Cervical Cancer Treatments
Guangdong Polytechnic Normal University
2025
Hainan Medical University
2023-2024
Gansu Provincial Hospital
2024
Fujian Provincial Cancer Hospital
2022
Fujian Medical University
2022
Zhuhai People's Hospital
2021
Jinan University
2021
Nanjing Medical University
2019-2020
University of Baltimore
2020
Johns Hopkins University
2020
Copper transporter 1 (CTR1) plays an important role in increasing cisplatin intake. Our previous studies showed that CTR1 expression was upregulated by (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, therefore enhanced sensitivity ovary cancer and non-small-cell lung (NSCLC) cells. In the current study cells, we uncovered potential mechanism of EGCG-induced through its pro-oxidative property. We found EGCG increased reactive oxygen species (ROS) generation, while presence ROS...
The emergence of castration-resistance is one the major challenges in management patients with advanced prostate cancer. Although spectrum systemic therapies that are available for use alongside androgen deprivation treatment castration-resistant cancer (CRPC) expanding, none these regimens curative. Therefore, it imperative to apply systems approaches identify and understand mechanisms contribute development CRPC. Using comprehensive proteomic approaches, we show a glycosylation-related...
Abstract Mitofusin 2 (MFN2) has been found to be downregulated in patients with Alzheimer disease (AD) but little is known about its roles the pathogenesis of AD. We explored mechanism N6-methyladenosine (m6A) methylation Mfn2 hippocampal mitochondrial dysfunction an AD mouse model. APP/PS1 transgenic mice underwent stereotaxic injection adeno-associated viruses and their behaviors were assessed. METTL3 MFN2 expressions measured by qRT-PCR Western blot, accompanied assessment morphology,...
In brief Preeclampsia is a pregnancy complication that can lead to severe adverse maternal and fetal outcomes, but the mechanisms underlying development of preeclampsia are not fully understood. This study shows ETV4 plays an essential role in proliferation, invasion, migration trophoblast cells by regulating MMP-2 MMP-9 involved pathogenesis preeclampsia. Abstract (PE) outcomes. However, PE ETS Variant Transcription Factor 4 (ETV4) important cell migration, invasion. this study, we aimed...
Temozolomide resistance is a major cause of recurrence and poor prognosis in neuroglioma. Recently, growing evidence has suggested that mitophagy involved drug various tumor types. However, the role molecular mechanisms temozolomide glioma remain unclear. In this study, levels temozolomide-resistant -sensitive cell lines were evaluated. The underlying regulation explored through RNA sequencing, roles differentially expressed genes investigated. We found promotes glioma. Specifically, small...
OBJECTIVE To investigate the effects of uroacitide (CDA-2), a cell differentiation agent, on growth inhibition and imatinib-(IM) resistant chronic myeloid leukemia (CML) cells. METHODS IM CML line K562R was established from K562. K562 cells were cultured with CDA-2 different concentrations. MTI method used to detect survival rates. Bone marrow IM-resistant non-IM-resistant patients collected co-incubated MTT colony-forming assays evaluate efficacy treatment for in lines, or bone patients;...
Objective: This study aimed to identify a subset of patients with stage IA2 IIA2 cervical cancer who are at low risk lymph node metastasis (LNM) using pathological parameters including estrogen receptor alpha (ERα) and progesterone (PR). Methods: The clinical data underwent radical surgery between 2014 2015 were retrospectively reviewed. Immunohistochemical staining was used determine the expression ERα PR. A low-risk criterion for LNM identified logistic regression analysis, its performance...
Abstract Patients with head and neck squamous cell carcinomas (HNSCCs) are treated surgery, radiation, chemotherapy, limited targeted therapies. Compared to human papillomavirus (HPV)-positive HNSCCs, HPV-negative cases have worse treatment response prognosis represent an unmet clinical need. We performed comprehensive proteogenomic characterization of tumor specimens, matched normal adjacent tissues (NATs), blood samples from 109 HNSCC patients. This cohort is dominated by tumors oral...