A5026808876- Dietary Effects on Health
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Gut microbiota and health
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Digestive system and related health
- Immune cells in cancer
- Diet and metabolism studies
- Glioma Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
University of California, Irvine
2021-2024
Point Loma Nazarene University
2021
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of CRC include environmental aspects, such as lifestyle and dietary factors, which are known to affect circadian clock. We find that both genetic disruption clock accelerate
Diet is a robust entrainment cue that regulates diurnal rhythms of the gut microbiome. We and others have shown disruption circadian clock drives progression colorectal cancer (CRC). While certain bacterial species been suggested to play driver roles in CRC, it unknown whether intestinal impinges on microbiome accelerate CRC pathogenesis. To address this, genetic clock, an Apc- driven mouse model was used define impact When combined with metagenomic sequencing identified dysregulation many...
Glucagon signaling governs REV-ERBα stability to modulate hepatic glucose production in a model of lung cancer cachexia.
The environmental light/dark cycle has left its mark on the body's physiological functions to condition not only our inner biology, but also interaction with external cues. In this scenario, circadian regulation of immune response emerged as a critical factor in defining host-pathogen and identification underlying circuitry represents prerequisite for development circadian-based therapeutic strategies. possibility track down metabolic pathway would represent unique opportunity direction....
Tumor angiogenesis is critical for the growth and progression of cancer. As such, angiostasis a treatment modality cancer with potential utility multiple types fewer side effects. However, clinical success angiostatic monotherapies has been moderate, at best, causing treatments to lose their early luster. Previous studies demonstrated compensatory mechanisms that drive tumor vascularization despite use monotherapies, as well combination therapies overcome these mechanisms. We screened...
<ns3:p>In modern society, there is a growing population affected by circadian clock disruption through night shift work, artificial light-at-night exposure, and erratic eating patterns. Concurrently, the rate of cancer incidence in individuals under age 50 increasing at an alarming rate, though precise risk factors remain undefined, potential links between deregulation young-onset cancers compelling. To explore complex biological functions clock, this review will first provide framework for...
In modern society, there is a growing population affected by circadian clock disruption through night shift work, artificial light-at-night exposure, and erratic eating patterns. Concurrently, the rate of cancer incidence in individuals under age 50 increasing at an alarming rate, though precise risk factors remain undefined, potential links between deregulation young-onset cancers compelling. To explore complex biological functions clock, this review will first provide framework for...
<h3>Background</h3> Colorectal cancer (CRC) is the third leading cause of cancer-related deaths and most diagnosed in United States. The circadian clock primary biological pacemaker body, which controls several physiological, endocrine metabolic processes that operate to maintain organismal homeostasis. Disruption this endogenous rhythm function has been linked cancers, yet precise molecular mechanisms detailed signaling pathways by disruption progression have not elucidated. In colorectal...