A5003879569- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Infant Nutrition and Health
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Breastfeeding Practices and Influences
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Hops Chemistry and Applications
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Immune responses and vaccinations
- Gut microbiota and health
- Neurological diseases and metabolism
- PI3K/AKT/mTOR signaling in cancer
- Magnesium in Health and Disease
- Obesity, Physical Activity, Diet
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
Reckitt Benckiser (Netherlands)
2021-2024
Radboud University Nijmegen
2014-2023
Radboud University Medical Center
2014-2023
Mead Johnson (United States)
2022-2023
University of Evansville
2022
Radboud Institute for Molecular Life Sciences
2016-2021
Leiden University Medical Center
2008-2015
Institute of Infection and Immunity
2013
General Department of Preventive Medicine
2011
MaineGeneral Medical Center
2011
Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration adipose tissue, resulting proinflammatory cytokine production. Both microbial and endogenous danger signals trigger assembly intracellular innate immune sensor Nlrp3, caspase-1 activation production cytokines IL-1β IL-18. Here, we showed that mice deficient apoptosis-associated speck-like protein, were resistant development high-fat diet-induced obesity, which correlated with...
SummaryGlycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric stimulator glucose-6-phosphate (G6P) and dephosphorylation through inactivation of GS kinase-3 with insulin. The relative importance these two regulatory mechanisms controlling not established, mainly due to complex interplay between multiple phosphorylation sites effectors. Here we identify residue that plays an important role activation G6P. We generated knockin mice which wild-type muscle was...
Obesity induces macrophages to drive inflammation in adipose tissue, a crucial step towards the development of type 2 diabetes. The tricarboxylic acid (TCA) cycle intermediate succinate is released from cells under metabolic stress and has recently emerged as signal induced by proinflammatory stimuli. We therefore investigated whether receptor 1 (SUCNR1) could play role tissue diabetes.Succinate levels were determined human plasma samples individuals with diabetes non-diabetic participants....
Abstract Stimulation of monocytes with microbial and non-microbial products, including oxidized low-density lipoprotein (oxLDL), induces a protracted pro-inflammatory, atherogenic phenotype sustained by metabolic epigenetic reprogramming via process called trained immunity . We investigated the intracellular mechanisms driving oxLDL-induced in human primary observed concomitant upregulation glycolytic activity oxygen consumption. In two separate cohorts healthy volunteers, we assessed impact...
PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 (S6K), and serum glucocorticoid-induced (SGK), that mediate many the effects insulin as well other agonists. interacts with phosphoinositides through pleckstrin homology (PH) domain. To study role this interaction, we generated knock-in mice expressing mutant incapable binding phosphoinositides. The are significantly small, resistant, hyperinsulinemic. Activation PKB is markedly reduced in result lower...
Akkermansia muciniphila (A. muciniphila) is an intestinal commensal with anti-inflammatory properties both in the intestine and other organs. The aim to investigate effects of oral administration A. on lipid metabolism, immunity, cuff-induced neointima formation hyperlipidemic APOE*3-Leiden (E3L).CETP mice.Hyperlipidemic male E3L.CETP mice are daily treated 2 × 108 CFU by gavage for 4 weeks determined plasma levels, immune parameters, composition. lowers body weight total cholesterol...
Abstract It has been well established that the presence of diabetes is accompanied by a chronic inflammatory state promoting various diabetes-associated complications. One potential driver this enhanced in patients with hyperglycemia. Even after blood glucose control achieved, complications persist, suggesting “hyperglycemic memory.” Innate immune cells, critically involved associated diabetes, can build nonspecific, immunological memory (trained immunity) via epigenetic regulation. We...
Infant gut microbiota composition is influenced by various factors early in life. Here, we investigate associations between infant microbiome development, age, breastfeeding duration, and human milk oligosaccharides (HMO) breastmilk.A total of 94 mother-infant pairs were recruited as part the Cambridge Baby Growth Breastfeeding Study (CBGS-BF) (Cambridge, UK). stool samples (n = 337) collected at 2 week, 6 3 month, month age. The 16S rRNA V3-V4 region was sequenced using MiSeq Illumina to...
The scavenger receptor CD36 facilitates the cellular uptake of long-chain fatty acids. As CD36-deficiency attenuates development high fat diet (HFD)-induced obesity, role in preadipocyte recruitment and adipocyte function was set out to characterize.Fat cell size number were determined gonadal, visceral, subcutaneous adipose tissue CD36(-/-) WT mice after 6 weeks on HFD. Basal lipolysis insulin-inhibited investigated gonadal tissue.CD36(-/-) showed a reduction all pads. Gonadal also lower...
Introduction: Childhood is a critical period for the development of executive functioning skills, including selective attention and inhibitory control, which are essential cognitive development. Optimal brain during this time requires appropriate levels macronutrient intake. Metabolomics can offer valuable insights into metabolites underlying gut-brain interactions. Objectives: This study aimed to explore use breathomics investigate associations between exhaled in children. Methods: Children...
Vanins are enzymes with pantetheinase activity and presumed to play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Pantothenic is an essential nutrient required synthesize coenzyme A, cofactor involved many biological processes such as fatty synthesis oxidation pyruvate fuel citric cycle. Hydrolysis pantetheine also liberates cysteamine, known antioxidant. Vanin-1 highly expressed liver under transcriptional control PPAR-α nutritional status, suggesting energy...
Abstract Vanins are enzymes that convert pantetheine to pantothenic acid (vitamin B5). Insights into the function of vanins have evolved lately, indicating vanin-1 play a role in inflammation, oxidative stress and cell migration. Moreover, has recently gained attention as novel modulator hepatic glucose lipid metabolism. In present study, we investigated development steatosis insulin resistance animal models obesity diabetes. addition, evaluated potency RR6, pharmacological inhibitor, an...
Activation of inflammatory pathways is known to accompany development obesity-induced non-alcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition caspase-1, the neutrophil serine proteases proteinase 3, elastase cathepsin G are able process inactive pro-inflammatory mediators IL-1β IL-18 their bioactive forms, thereby regulating responses. present study, we investigated whether 3 involved in NAFLD. We NAFLD mice deficient for elastase/proteinase...
The article investigates whether chronic hyperglycaemia in Type 1 diabetes (T1D) is associated with a proinflammatory immune signature and arterial wall inflammation, driving the development of atherosclerosis.Patients T1D (n = 41), healthy age-, sex-, body mass index-matched controls 20) were recruited. Arterial inflammation haematopoietic activity measured 2'-deoxy-2'-(18F)-fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography. In addition, flow cytometry circulating...