A5091640418- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Venous Thromboembolism Diagnosis and Management
- Christian Theology and Mission
- Global Maritime and Colonial Histories
- Asian Studies and History
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Religion, Society, and Development
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Pharmacology and Obesity Treatment
- American Constitutional Law and Politics
- Immune Response and Inflammation
- Cardiovascular Disease and Adiposity
- Islamic Studies and History
- Theology and Philosophy of Evil
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Jeroen Bosch Ziekenhuis
2005-2025
Radboud University Medical Center
2009-2021
Radboud University Nijmegen
2009-2021
Bohn Stafleu van Loghum (Netherlands)
2019
Radboud Institute for Molecular Life Sciences
2017
Liverpool John Moores University
2017
Wageningen University & Research
2017
Institute of Infection and Immunity
2013
University Medical Center Groningen
2012
University of Groningen
2012
Abstract Autophagy, an evolutionary conserved process aimed at recycling damaged organelles and protein aggregates in the cell, also modulates proinflammatory cytokine production peripheral blood mononuclear cells. Because adipose tissue inflammation accompanied by elevated levels of cytokines is characteristic for development obesity, we hypothesized that modulation autophagy alters inflammatory gene expression secretion. We tested our hypothesis using ex vivo studies human mouse tissue....
Diabetes is associated with a high risk of adverse pregnancy outcomes. Optimal glycaemic control fundamental and traditionally monitored self-measured glucose profiles periodic HbA1c measurements. We investigated the effectiveness additional use retrospective continuous monitoring (CGM) in diabetic pregnancies.We performed nationwide multicentre, open label, randomized, controlled trial to study pregnant women type 1 or 2 diabetes who were undergoing insulin therapy at gestational age < 16...
The Nav1.7 sodium channel is preferentially expressed in nocioceptive dorsal root ganglion and sympathetic neurons. Gain-of-function mutations produce the nocioceptor hyperexcitability underlying inherited erythromelalgia, characterized most kindreds by early-age onset of severe pain. Here we describe a mutation (Nav1.7-G616R) pedigree with adult-onset pain some family members. shifts voltage-dependence fast-inactivation depolarizing direction adult-long, but not neonatal-short splicing...
Glycated haemoglobin (HbA1c) is associated with cardiovascular disease risk in individuals without diabetes, and its use has been recommended for diagnosing diabetes. Therefore, it important to gain further understanding of the determinants HbA1c. The aim this study was investigate effects genetic loci clinical lifestyle parameters, their interactions, on HbA1c nondiabetic adults.Population-based cohort study.Three northern provinces Netherlands.A total 2921 adults participating...
The determinants of insulin-associated weight gain in type 2 diabetes mellitus (T2DM) are partly unknown. Therefore, we conducted a prospective study to identify predictors gain.In patients with T2DM, assessed physical activity by accelerometry and measured diabetes-related distress questionnaires before 6 12 months after starting insulin therapy. Glycemic control (HbA1c) dose were monitored.After therapy, mean body had increased 3.0 ± 2.5 kg (P < 0.001). drop HbA1c was correlated gain. With...
Obesity is accompanied by the presence of chronic low-grade inflammation manifested infiltration macrophages into adipose tissue. Mannose-binding lectin (MBL), a soluble mediator innate immunity, promotes phagocytosis and alters macrophage function. To assess function MBL in development obesity, we studied wild-type MBL(-/-) mice rendered obese using high-fat diet (HFD). Whereas no gross morphological differences were observed liver, an HFD provoked distinct changes tissue morphology mice....
Innate immunity plays a pivotal role in obesity-induced low-grade inflammation originating from adipose tissue. Key receptors of the innate immune system including Toll-like receptors-2 and -4 (TLRs) are triggered by nutrient excess to promote inflammation. The other TLRs this process is largely unknown. In addition double-stranded viral mRNA, TLR-3 can also recognize mRNA dying endogenous cells, that frequently observed within obese Here, we identified profound expression adipocytes...
Abstract Increased glycolysis is a metabolic trait of activated innate immune cells and supports functional changes including cytokine production. Insulin drives in nonimmune cells, yet its effects on human remain unexplored. Potential insulin cell metabolism may occur acutely after postprandial increase plasma levels or as consequence chronically elevated observed obese insulin-resistant individuals patients with diabetes. Here, we investigated the acute chronic exposure to function primary...
Chronic low-grade inflammation in adipose tissue often accompanies obesity, leading to insulin resistance and increasing the risk for metabolic diseases. MAP3K8 (TPL2/COT) is an important signal transductor activator of pro-inflammatory pathways that has been linked obesity-induced inflammation. We used human biopsies study relationship expression with markers obesity cytokines (IL-1β, IL-6 IL-8). Moreover, we evaluated mice lacking WT on a high-fat diet (HFD) 16 weeks. Individuals BMI >30...
Abstract Background Pronounced weight gain frequently complicates insulin therapy in patients with type 2 diabetes (T2 DM ). We have previously reported that addition of liraglutide for 26 weeks can reverse insulin‐associated gain, decrease dose and improve glycaemic control, as compared continuation standard treatment. Objectives To investigate whether the beneficial effects are sustained up to 52 similar could be obtained when is added 6 months later. Methods Adult T2 ≥4% within 16...
Introduction In women with gestational diabetes mellitus (GDM) requiring pharmacotherapy, insulin was the established first-line treatment. More recently, oral glucose lowering drugs (OGLDs) have gained popularity as a patient-friendly, less expensive and safe alternative. Monotherapy metformin or glibenclamide (glyburide) is incorporated in several international guidelines. who do not reach sufficient control OGLD monotherapy, usually added, either without continuation of OGLDs. No reliable...
Patients with type 2 diabetes mellitus (T2DM) are typically overweight and have an increased liver fat content (LFAT). High LFAT may be explained by efflux of free fatty acids from the adipose tissue, which is partly instigated inflammatory changes. This would imply association between features tissue content.To analyse associations content.A cross-sectional study.Twenty-seven obese patients insulin-treated T2DM were studied.LFAT was measured proton magnetic resonance spectroscopy. A...