A5058341945- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Dialysis and Renal Disease Management
- Diabetes and associated disorders
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Muscle activation and electromyography studies
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parkinson's Disease and Spinal Disorders
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Diabetic Foot Ulcer Assessment and Management
- Medical Imaging and Pathology Studies
KU Leuven
2013-2021
Radboud University Medical Center
2002-2015
Radboud University Nijmegen
1996-2015
Based on the data derived from Modification of Diet in Renal Disease (MDRD) study, a new equation was developed for estimation glomerular filtration rate (GFR). This equation, which takes into account body weight, age, sex, serum creatinine, race, urea, and albumin, provided more accurate GFR patients with renal insufficiency. However, this prediction has not been validated subjects normal or supra-normal GFR.In cross-sectional we measured by inulin clearance 46 healthy controls...
Abstract In Parkinson's disease (PD), freezing of gait (FOG) is associated with widespread functional and structural gray matter changes throughout the brain. Previous study freezing‐related white was restricted to brainstem cerebellar locomotor tracts. This undertaken determine spatial distribution damage FOG by combining whole brain striatofrontal seed‐based diffusion tensor imaging. Diffusion‐weighted images were collected in 26 PD patients 16 age‐matched controls. groups (n = 11) without...
In daily clinical practice creatinine clearance is used as marker of glomerular filtration rate (GFR). As a result the tubular secretion process endogenous (ECC) overestimates rate, particularly in patients with impaired renal function. It has been suggested that handling altered nephrotic syndrome.Inulin (GFR) and have simultaneously measured cohort 42 proteinuria 45 healthy controls. The by (TScreat) can be estimated ECC-GFR. TScreat was calculated both groups. Regression analysis...
Patients with chronic kidney disease (CKD) are at risk for progression to failure. Using data of Canadian CKD patients, Tangri et al. recently developed models predict the stages 3-5 failure within 5 years. We validated this equation (KFRE) in European patients.We selected non-transplanted patients who participated MASTERPLAN study, a randomized controlled trial CKD. Kidney was defined as initiation dialysis or transplantation died before were censored. followed <5 years, did not develop and...
Abstract Background Glomerular hyperfiltration plays a role in the pathophysiology of diabetic nephropathy. An increase glomerular filtration rate (GFR) could result from primary actions at glomerular/vascular level or be consequence proximal tubular sodium reabsorption resulting systemic volume expansion. Recently it was hypothesized that an may lead to through tubulo‐glomerular feedback mechanism (tubular‐hypothesis) without Design We have studied 54 normoalbuminuric patients with type 1...
Background Patients with Parkinson's disease (PD) and freezing of gait (FOG) suffer from more impaired motor cognitive functioning than their non-freezing counterparts. This underlies an even higher need for targeted rehabilitation programs in this group. However, so far it is unclear whether FOG affects the ability consolidation generalization learning thus efficacy rehabilitation. Objective To investigate hallmarks people compared to those without by comparing effects intensive program...
ABSTRACT Background Micrographia occurs in approximately 60% of people with Parkinson's disease (PD). Although handwriting is an important task daily life, it not clear whether relearning and consolidation (ie the solid storage motor memory) this skill possible PD. The objective was to conduct for first time a controlled study into effects intensive learning improve micrographia Methods In placebo‐controlled study, 38 right‐handed PD were randomized 2 groups, receiving 1 equally...
Abstract The onset of freezing gait (FOG) in Parkinson’s disease (PD) is a critical milestone, marked by higher risk falls and reduced quality life. FOG associated with alterations subcortical neural circuits, yet no study has assessed whether morphology can predict the clinical FOG. In this prospective multimodal neuroimaging cohort study, we performed vertex-based analysis grey matter fifty-seven individuals PD at entry two years later. We also explored behavioral correlates resting-state...
Background. Patients with freezing of gait (FOG) have more difficulty switching tasks as well controlling the spatiotemporal parameters than patients without FOG. Objective. To compare ability and FOG to adjust their sudden speed prolonged walking in asymmetrical conditions. Methods. Gait characteristics 10 freezers, 12 non-freezers, controls were collected during tied-belt conditions (3 4 km/h), motor reswitching (increase one belt from 3 km/h vice versa), adaptation (adjustment gait)...
This exploratory study aimed to identify which aspects of postural control are able distinguish between subgroups patients with Parkinson's disease (PD) and controls. Balance was tested using static dynamic posturography. Freezers (n = 9), nonfreezers 10), controls 10) stood on a movable force platform performed 3 randomly assigned tests: (1) sensory organization test (SOT) evaluate the effective use information, (2) motor (MCT) assess automatic reactions in response perturbations, (3)...
We evaluated whether elderly patients with pulmonary tuberculosis and without apparent preexisting liver disease are at an increased risk to develop hepatotoxicity from isoniazid-rifampin regimen require regular function tests in comparison younger patients. analyzed the data of 131 treated period 1980-1985 whom 64 (49%) were least 60 yr age. Subsequent increases transaminases (measured weekly for as long 4 wk after start treatment later on when symptoms suggestive occurred) above baseline...
Background. Recent studies show that patients with Parkinson’s disease (PD) and freezing of gait (FOG) experience motor problems outside their episodes. Because handwriting is also a sequential movement, it may be affected in PD FOG relative to those without. Objective. The current study aimed assess the quality writing without comparison healthy controls (CTs) during various tasks. Methods. Handwriting was assessed by cursive loops on touch-sensitive tablet means Systematic Screening...
Recent studies show that besides freezing of gait (FOG), many people with Parkinson's disease (PD) also suffer from in the upper limbs (FOUL). Up to now, it is unclear which task constraints provoke and explain limb freezing.To investigate whether other kinematic abnormalities during writing are provoked by (i) gradual changes amplitude or (ii) sustained generation patients without gait.Thirty-four PD, including 17 FOG, performed a on touch-sensitive tablet requiring at constant small large...
The postural instability and gait disorder (PIGD) tremor dominant (TD) subtypes of Parkinson's disease (PD) show different patterns alterations in functional connectivity (FC) between specific brain regions. This study aimed to investigate the relation symptomatic heterogeneity PD structural underlying these FC changes.68 patients classified as PIGD (n = 41) or TD 19) 19 age-matched controls underwent Magnetic Resonance Imaging (MRI). Diffusion-weighted images were used assess fractional...
Background It has been suggested that atrial natriuretic peptide (ANP) contributes to the glomerular hyperfiltration of diabetes mellitus. Infusion ANP increases urinary excretion albumin in patients with type 1 mellitus (IDDM). Although increased albuminuria is attributed a rise pressure, alterations tubular protein handling might be involved. Patients and methods We have studied effects nine microalbuminuric IDDM patients. After obtaining baseline parameters, was infused over 1‐h period...
Background and Purpose: Individuals with Parkinson disease exhibit decreased axial head-pelvis rotation. Consequently, they turn more en bloc than healthy controls, which may contribute to freezing during turning. We wanted understand the influence of auditory cueing an attentional strategy on turning how this related gait (FOG). Methods: Fifteen participants FOG were asked 180° baseline condition, unilateral cueing, prompting start head rotation first. occurrence, rotation, center mass...
Background:The onset of freezing gait (FOG) represents a turning point in the lives patients with Parkinson's disease (PD). FOG increases fall risk and is associated worse physical mental health related quality life, thus increasing burden. Moreover, therapeutic studies ai ming to ameliorate have had limited success. In step towards pre-emptive therapy delay or prevent FOG, this prospective cohort study set out uncover clinical markers conversion FOG. Objective:Investigate Methods:Sixty PD...