A5086091840- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- GDF15 and Related Biomarkers
- Renal and related cancers
- Anesthesia and Pain Management
- Preterm Birth and Chorioamnionitis
- Intensive Care Unit Cognitive Disorders
- Circular RNAs in diseases
- Gestational Trophoblastic Disease Studies
- Lichen and fungal ecology
- Biocrusts and Microbial Ecology
- Connective tissue disorders research
- Organ Transplantation Techniques and Outcomes
- Electrolyte and hormonal disorders
- Galectins and Cancer Biology
Mercy Hospital for Women
2016-2025
The University of Melbourne
2015-2024
Harvard University
2023-2024
Massachusetts General Hospital
2023-2024
University of Mississippi Medical Center
2024
Northern Hospital
2015
Edinburgh Royal Infirmary
1989
Opioids administered to treat postsurgical pain are a major contributor the opioid crisis, leading chronic use in considerable proportion of patients. Initiatives promoting opioid-free or opioid-sparing modalities perioperative management have led reduced administration operating room, but this reduction could unforeseen detrimental effects terms postoperative outcomes, as relationship between intraoperative usage and later requirements is not well understood.To characterize association...
While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of stillbirths occur in appropriate-for-gestational-age (AGA, > 10th centile) fetuses. AGA fetuses are plausibly also at stillbirth if present. Such may be expected demonstrate declining growth trajectory across pregnancy, although they do not fall below the centile before birth. We investigated whether reduced velocity associated with antenatal, intrapartum and neonatal indicators...
Abstract Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental insufficiency, especially near-term gestation when the risk of stillbirth rises. Here we show a strong association between low circulating plasma serine peptidase inhibitor Kunitz type-1 (SPINT1) concentrations at 36 weeks’ birthweight, an indicator insufficiency. We generate 4-tier model based on SPINT1 concentrations, where highest tier has approximately...
ABSTRACT Objective Fetal growth restriction (FGR) is a major risk factor for stillbirth and most commonly arises from uteroplacental insufficiency. Despite clinical examination third‐trimester fetal biometry, cases of FGR often remain undetected antenatally. Placental insufficiency known to be associated with altered blood flow resistance in maternal, placental vessels. The aim this study was evaluate the performance individual combined Doppler measurements prediction term...
Background We investigated the biomarker potential of growth differentiation factor 15 (GDF‐15), a stress response protein highly expressed in placenta, to predict preeclampsia. Methods and Results In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 41 preeclampsia), plasma concentrations GDF‐15 at 36 weeks' gestation were significantly increased among those preeclampsia ( P <0.001), area under receiver operating characteristic curves (AUC)...
BackgroundLipids serve as multifunctional metabolites that have important implications for the pregnant mother and developing fetus. Abnormalities in lipids emerged potential risk factors pregnancy diseases, such preeclampsia fetal growth restriction. The aim of this study was to assess lipid detection late-onset restriction.MethodsWe used a case-cohort 144 maternal plasma samples at 36 weeks' gestation from patients before diagnosis (n = 22), delivery restricted infant 55, defined <5th...
Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk stillbirth. has pathophysiological features in common preeclampsia. We hypothesised that angiogenesis-related factors maternal plasma, known predict preeclampsia, may also detect fetal at 36 weeks' gestation. therefore set out determine the diagnostic performance soluble fms-like tyrosine kinase 1 (sFlt-1), factor (PlGF), and sFlt-1:PlGF ratio, measured gestation, identifying women who...
Background Preeclampsia is pregnancy specific, involving significant maternal endothelial dysfunction. Predictive biomarkers are lacking. We evaluated the biomarker potential, expression, and function of PSG7 (pregnancy-specific β-1 glycoprotein 7) PSG9 9) in preeclampsia. Methods Results At 36 weeks gestation preceding term preeclampsia diagnosis, (in Australian cohorts n=918 n=979, respectively) were significantly increased before onset (PSG7, P=0.013; PSG9, P=0.0011). In samples collected...
Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-gestational-age (SGA; weight < 10th centile) commonly used proxy FGR, detection of FGR among appropriate-for-gestational-age (AGA; ≥ fetuses remains an unmet need in clinical care. We aimed determine whether reduced antenatal velocity from the time routine mid-trimester ultrasound associated with antenatal, intrapartum and postnatal indicators term AGA infants.Three hundred...
Abstract Background: Preeclampsia is a severe complication of pregnancy. Chemerin an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential circulating chemerin to predict preeclampsia. Methods: Maternal plasma placenta were collected women with early-onset preeclampsia (&lt;34 weeks), eclampsia, or before diagnosis (36 weeks). Human trophoblast stem cells differentiated into syncytiotrophoblast extravillous trophoblasts...
Background Postnatally, small-for-gestational-age (SGA; birthweight <10th centile) infants who are growth restricted due to uteroplacental insufficiency (UPI) demonstrate 'catch-up growth' meet their genetically-predetermined size. Infants slowing during pregnancy those that cross estimated fetal weight centiles at serial ultrasound examinations. These slow in but born appropriate-for-gestational-age (AGA; ≥10th centile), exhibit antenatal, intrapartum and postnatal indicators of UPI. Here,...
Abstract Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ injury. A predictive test to identify those who will develop preeclampsia could substantially decrease morbidity mortality. MicroRNAs (miRs) are small RNA molecules involved in post-transcriptional gene regulation. We screened for circulating miRs differentially expressed at 36 weeks’ gestation pregnancies before the development of preeclampsia. used...
Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is functionally related protease inhibitor. This study aimed to characterise expression in insufficiency. Circulating was assessed three prospective cohorts, collected at the following: (1) term delivery (n = 227), (2) 36 weeks 364), and (3) 24-34 weeks' 294) gestation. also measured plasma placentas of women with established disease preterm (<34 weeks) delivery. Using...
Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia human trophoblast stem cells (hTSCs). was measured placental lysates plasma collected from patients early-onset (delivered <34 weeks' gestation) gestation matched controls. Placental protein significantly reduced 43 compared 21 mRNA expression LGALS3 (galectin-3 encoding gene) 29...
Metabolomics is the study of small molecules (metabolites), within cells, tissues and biofluids. Maternal metabolites can provide important insight into health development both mother fetus throughout pregnancy. This assessed metabolic profiles in maternal circulation prior to at time diagnosis preeclampsia fetal growth restriction. plasma samples were collected from two independent cohorts: (1) Established disease cohort: 50 participants diagnosed with early-onset (< 34 weeks' gestation),...