A5001931132- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Maternal and Neonatal Healthcare
- Respiratory viral infections research
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Global Public Health Policies and Epidemiology
- Bacterial Infections and Vaccines
- Cardiovascular Function and Risk Factors
- Pneumonia and Respiratory Infections
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- COVID-19 epidemiological studies
- Acute Myocardial Infarction Research
- Zoonotic diseases and public health
- Venous Thromboembolism Diagnosis and Management
- Trauma and Emergency Care Studies
- Global Maternal and Child Health
- Diabetes Treatment and Management
- Healthcare Regulation
- Infective Endocarditis Diagnosis and Management
Hospital de São João
2010-2025
Universidade Municipal de São Caetano do Sul
2021-2024
Instituto de Infectologia Emílio Ribas
1996-2024
Universidade do Porto
2023
Universidade Nove de Julho
2018-2021
Management Support Technology (United States)
2021
University of California, Irvine
2021
University of Oxford
2021
King's College Hospital
2021
Ministério da Saúde
2010-2018
Brazil has been severely hit by COVID-19, with rapid spatial spread of both cases and deaths. We used daily data on reported deaths to understand, measure, compare the spatiotemporal pattern across municipalities. Indicators clustering, trajectories, speed, intensity movement COVID-19 interior areas, combined indices policy measures, show that although no single narrative explains diversity in spread, an overall failure implementing prompt, coordinated, equitable responses a context stark...
Heterogeneity in COVID-19 morbidity and mortality is often associated with a country's health-services structure social inequality. This study aimed to characterize inequalities São Paulo, the most populous city Brazil Latin America. We conducted population-based study, including deaths among Paulo residents from March September 2020. Age-standardized rates unadjusted rate ratios (RRs) [with corresponding 95% confidence intervals (CIs)] were estimated by race, sex, age group, district of...
Real-time (RT)-PCR increases diagnostic yield for bacterial meningitis and is ideal incorporation into routine surveillance in a developing country. We validated multiplex RT-PCR assay Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae Brazil. Risk factors being culture-negative, positive were determined. The sensitivity of cerebrospinal fluid (CSF) was 100% (95% confidence limits, 96.0%–100%) N. 97.8% (85.5%–99.9%) S. 66.7% (9.4%–99.2%) H. influenzae. Specificity...
In March 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in routine infant immunization program using a 4-dose schedule and catch-up for children <23 months. We investigated PCV10 effect on nasopharyngeal carriage with vaccine-type Streptococcus pneumoniae (Spn) non-typeable Haemophilus influenzae (NTHi) among São Paulo city. Cross-sectional surveys were conducted 2010 (baseline) 2013 (post-PCV10). Healthy PCV-naïve aged 12–23 months recruited from primary health...
Objectives . To identify factors associated with death in visceral leishmaniasis (VL) cases. Patients and Methodology We evaluated prognostic for from VL São Paulo state, Brazil, 1999 to 2005. A study nested a clinical cohort was carried out by data analysis of 376 medical files. comparison between fatal cases survivors performed clinical, laboratory, biological features. Association variables assessed univariate analysis, the multiple logistic regression model used determine adjusted odds...
Nonbacterial thrombotic endocarditis is a rare condition characterized by the formation of noninfectious vegetations on heart valves. It related with systemic embolic phenomena occurring predominantly in advanced cancer stages, particularly adenocarcinomas. diagnosis exclusion based clinical context, echocardiographic findings vegetation, and negative blood cultures, distinction between infective challenging. We report case 66‐year‐old woman, history previously treated breast urothelial...
Objetivou-se analisar a estratégia fármaco-invasiva pré-hospitalar do serviço de saúde público da região oeste Paraná. Trata-se um estudo retrospectivo, partir banco dados Secretaria Estadual Saúde (SESA-Pr) dezembro 2020 até novembro 2023. A idade média dos pacientes foi 62 anos (+/- 12,5), 62% eram sexo masculino e 53,3% apresentaram reversão supra ST. O tempo mediano diagnóstico realização trombólise 119 minutos. cateterismo resgate necessário em 29 (31,5%) pacientes. Foram registrados 8...
Abstract During 2010, outbreaks of serogroup C meningococcal (MenC) disease occurred in 2 oil refineries São Paulo State, Brazil, leading to mass vaccination employees at 1 refinery with a polysaccharide A/C vaccine. A cross-sectional study was conducted assess the prevalence meningococci carriage among workers both and investigate effect on risk factors for pharyngeal meningococci. Among vaccinated nonvaccinated workers, rates overall (21.4% 21.6%, respectively) MenC (6.3% 4.9%, were...
The evaluation of the health conditions a population from information systems is an important tool for supporting managers taking decision. Ministry Health Brazil has universal with open access on website Department Informatics SUS-DATASUS. results showed dengue and meningococcal disease, low uptake in SIM, when compared to SINAN. Leptospirosis presented similar number deaths both systems, tetanus visceral leishmaniasis, some years, by SIM higher than study shows need strengthen improve...
OBJETIVO Descrever a investigação do surto de febre amarela silvestre e as principais medidas controle realizadas no estado São Paulo. MÉTODOS Estudo descritivo na região sudoeste estado, entre fevereiro abril 2009. Foram avaliados casos suspeitos confirmados em humanos primatas não humanos. A entomológica, ambiente silvestre, envolveu captura solo copa árvore para identificação das espécies detecção infecção natural. ações Aedes aegypti áreas urbanas. vacinação foi direcionada residentes...
In 2010, introduction of the meningococcal C conjugate vaccine in Brazil for children <2 years provided an immediate reduction incidence rates disease among age groups targeted vaccine, but no early impact was observed unvaccinated groups. Knowledge about carriage is crucial improving our understanding epidemiology and designing effective vaccination programs. Taking account very limited published data currently available describing Brazil, we performed a study to evaluate prevalence...
This case-control study aimed to assess the risk factors for death from influenza A(H1N1)pdm09 in patients with laboratory confirmation, who had severe acute respiratory illness-SARI and were hospitalized between June 28th August 29th 2009, metropolitan regions of São Paulo Campinas, Brazil. Medical charts all 193 died (cases) 386 randomly selected recovered (controls) investigated 177 hospitals. Household interviews conducted those survived closest relative died. 73.6% cases 38.1% controls...
Although Industry 4.0 has received much attention in recent years due to the possibility of increasing companies’ productivity, implementation process is complex. The aim this study present a holistic model for implementing based on cleaner production as fundamental tool development systems that meet Sustainable Development 04026-002Goals (SDGs), and social stakeholders cooperate with process, helping develop sustainable infrastructure, processes technologies increase transformation these...
In February 2012, crew and passengers of a cruise ship sailing off the coast São Paulo, Brazil, were hospitalized for acute respiratory illness (ARI). A field investigation was performed to identify disease involved factors associated.Information on with ARI obtained from medical records individuals. Active case finding onboard ship. defined as presence one nonspecific symptom (fever, chills, myalgia, arthralgia, headache, or malaise) (cough, nasal congestion, sore throat, dyspnea)....
Abstract Yellow fever (YF) vaccine can cause neurologic complications. We examined YF vaccine–associated disease reported from 3 tertiary referral centers in São Paulo, Brazil, during 2017–2018 and compared the performance of criteria established by Fever Vaccine Working Group/Centers for Disease Control Prevention Brighton Collaboration. Among 50 patients who met inclusion criteria, 32 had meningoencephalitis (14 with reactive IgM cerebrospinal fluid), 2 died, 1 may have transmitted...
In patients with established heart failure (HF) low total cholesterol levels associate worse prognosis. Evidence concerning the impact of Low-density lipoprotein (LDL-c) in HF is scarce. We aimed to evaluate prognostic LDL-c HF, both and without diabetes mellitus (DM). retrospectively analyzed outpatients chronic systolic dysfunction followed our clinic from January/2012 May/2018. was calculated using Friedewald's formula. Patients a complete lipid profile were excluded. The endpoint under...
Recently, reactivation of Chagas disease (meningoencephalitis and/or myocarditis) was included in the list AIDS-defining illnesses Brazil. We report a case 52-year-old patient with no history previous who presented acute meningoencephalitis. Direct examination blood and cerebrospinal fluid (CSF) showed Trypanosoma cruzi. CSF culture confirmed diagnosis. Serological assays for T. cruzi human immunodeficiency virus (HIV) were positive. Despite treatment benznidazol supportive measures, died 24...
Introduction An ongoing outbreak of yellow fever (YF) has been reported in Brazil with 1261 confirmed cases and 409 deaths since July 2017. To date, there is no specific treatment available for YF. Recently published papers describing vitro animal models suggest a potential effect antiviral drugs (approved the hepatitis virus) against flaviviruses, including The primary aim this study to analyse sofosbuvir on viral kinetics clinical outcomes among patients presenting This multicentre...
Faced with the reemergence of yellow fever (YF) in metropolitan region São Paulo, Brazil, we developed a retrospective study to describe cases YF attended at Institute Infectology Emilio Ribas from January March 2018 and analyze factors associated death, information obtained hospital epidemiological investigation. A total 72 sylvatic were confirmed, 21 deaths (29.2% lethality rate). Cases concentrated males (80.6%) age group 30 59 years (56.9%). Two logistic regression models performed,...