A5043140806- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Antifungal resistance and susceptibility
- RNA regulation and disease
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Stroke Rehabilitation and Recovery
- Viral-associated cancers and disorders
- Liver Disease Diagnosis and Treatment
- Sexual function and dysfunction studies
- Viral Infections and Immunology Research
- Air Quality and Health Impacts
- HIV/AIDS Research and Interventions
- Circular RNAs in diseases
- Polyomavirus and related diseases
- HIV-related health complications and treatments
- Galectins and Cancer Biology
- Indoor Air Quality and Microbial Exposure
- Nail Diseases and Treatments
- Hormonal and reproductive studies
- Peripheral Neuropathies and Disorders
Instituto de Infectologia Emílio Ribas
2014-2025
Universidade de São Paulo
2021-2022
Brazilian Society of Tropical Medicine
2022
Instituto de Medicina Tropical
2021
Instituto Adolfo Lutz
2021
Management Support Technology (United States)
2021
University of California, Irvine
2021
Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurologic manifestations do not meet diagnostic criteria for HAM/TSP. These conditions later progress to HAM/TSP or constitute an intermediate clinical form, between asymptomatic carriers and those full myelopathy. Our aim was determine the prevalence HTLV-1-associated disease in subjects without HAM/TSP, relationship these findings proviral load (PVL). Methods: 175 HTLV-1-infected were submitted...
Neurological manifestations associated with COVID-19 remain partially described, mainly in low- and middle-income countries where diagnostic tools are limited. To address this, we assembled medical centers Brazil the goal of describing neurological syndromes during first wave pandemic. From June 1st, 2020 to 2021, non-consecutive adult patients new onset six up 60 days after confirmed were included. Data compiled from four tertiary compared general local data, as well a previous cohort...
HIV-associated neurocognitive disorders (HAND) remain frequent even among individuals receiving combined antiretroviral therapy (cART). In addition, HAND may adversely affect the quality of life and adherence to cART. There is scarce epidemiological information about in Latin America. This cross-sectional study recruited HIV-infected patients from a tertiary teaching institution São Paulo, Brazil, between May 2013 February 2015. The were adults with at least 4 years education current...
Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of neurological and clinical manifestations do not meet diagnostic criteria for HAM. These conditions later progress to HAM or constitute an intermediate form: syndrome (IS), mid-point between asymptomatic carriers those full myelopathy. Thus, we determined the incidence cases in HTLV-1-asymptomatic IS patients, clinical/laboratory markers. A total 204 HTLV-1-positive patients were included this study,...
Background: Previous reported neurologic sequelae associated with SARS-CoV-2 infection have mainly been confined to hospital-based patients in which viral detection was restricted nasal/throat swabs or IgM/IgG peripheral blood serology. Here we describe seven cases from Brazil of outpatients previous mild moderate COVID-19 who developed subacute cognitive disturbances. Methods: From June 1 August 15, 2020, individuals 18 60 years old, confirmed mild/moderate and findings consistent...
In the context of megacities in an urban environment, air quality is important issue, due to direct correlation population's health. The biomonitoring pollutants can indicate subtle environmental alterations, for that, anemophilous fungi be monitored changes atmospheric conditions related pollution. present study, concentration and bacteria atmosphere was measured during a specific vehicle fleet reduction city São Paulo, Brazil, from May 24 30, 2018, using impactor samplers. number isolated...
Abstract Yellow fever (YF) vaccine can cause neurologic complications. We examined YF vaccine–associated disease reported from 3 tertiary referral centers in São Paulo, Brazil, during 2017–2018 and compared the performance of criteria established by Fever Vaccine Working Group/Centers for Disease Control Prevention Brighton Collaboration. Among 50 patients who met inclusion criteria, 32 had meningoencephalitis (14 with reactive IgM cerebrospinal fluid), 2 died, 1 may have transmitted...
Abstract Background HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy available, but corticosteroids provide some clinical benefit. Although HAM/TSP pathogenesis not fully elucidated, older age, female sex and higher proviral load are established risk factors. We investigated systemic cytokines a novel chronic inflammatory marker, GlycA, as possible biomarkers of immunopathogenesis...
Background: Despite its relatively low incidence of associated diseases, Human T-cell Leukemia Virus-1 (HTLV-1) infection was reported to carry a significant risk mortality in several endemic areas. HTLV-1-associated adult leukemia/lymphoma (ATLL) and myelopathy/tropical spastic paraperesis (HAM/TSP), as well frequent coinfections with human immunodeficiency virus (HIV), hepatitis C (HCV), Strongyloides stercoralis were increased morbidity HTLV-1 infection. Objective: To determine the rate...
Background:The aim of this study was to evaluate the frequency, spectrum, in-hospital mortality rate, and factors associated with death in people living HIV/AIDS (PLWHA) presenting neurological diseases from a middle-income country, as well estimate its one-year global rate.Methods:This prospective observational cohort conducted at Brazilian tertiary health center between January July 2017. HIV-infected patients above 18 years age who were admitted due complaints consecutively included. A...
The cause of oropharyngeal dysphagia in patients with coronavirus disease (COVID-19) can be multifactorial and may underly limitations swallowing rehabilitation.
Human T-Lymphotropic Virus type-1 (HTLV-1) is a unique retrovirus associated with both leukemogenesis and specific neuroinflammatory condition known as HTLV-1-Associated Myelopathy (HAM). Currently, most proposed HAM biomarkers require invasive CSF sampling, which not suitable for large cohorts or repeated prospective screening. To identify non-invasive incident in Brazilian cohort of PLwHTLV-1 (n=615 6,673 person-years clinical follow-up), we selected all plasma samples available at the...
BACKGROUND: During the natural history, incidence HTLV-1 related diseases were 0.5% until 10% after decades of infection. Despite relative low lethality, previous study observed that infection is associated with significantly increased mortality. For example, ATLL and HAM/TSP, co-infections HIV HCV, parasitic co-infection Strongyloides stercoralis may increase morbidity OBJECTIVE: Determine mortality rate its major variables as possible risk factors, analyzing HTLV Clinic at Emilio Ribas...
Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% deaths 65% recommends searching coinfections that increase the progression of chronic liver towards cirrhosis hepatocellular carcinoma. Aims methodology This study aimed add information concerning influence human T-lymphotropic virus type 1 (HTLV-1) 2 (HTLV-2) in C, since Brazil, these retroviruses are endemic but neglected. Serum samples from 1,910 patients with 1,315 São Paulo,...
Disseminated histoplasmosis (DH) is endemic in Latin America and the Caribbean where diagnostic tools are restricted. We carried-out a 1-year prospective cohort study at referral hospital São Paulo, Brazil. Participants had > or =18 years old, were hospitalized due to any indication CD4+ < 200 cells/µl. A urine commercial monoclonal Histoplasma galactomannan enzyme-linked immunosorbent assay (IMMY, Norman, OK, USA) 'in house' blood nested PCR performed all cases. Probable/proven DH cases...
Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropic spastic paraparesis (HAM/TSP) is an insidiously progressive spinal cord disease for which there no effective treatment. There great interest in developing potential biomarkers to predict the pathogenesis of HAM/TSP disease. In this study, Illumina Massive Parallel Sequencing (MPS) technology was used investigate cellular global noncoding RNAome expression profile patients (n = 10), asymptomatic HTLV-1-infected...
Cerebral toxoplasmosis continues to cause high morbidity and mortality in developing countries. The association of sulfadiazine pyrimethamine is considered the standard therapy; however, it has potential disadvantages. This single-arm open-label clinical trial was carried out a tertiary hospital São Paulo, Brazil. We included patients at least 18 years age, whose HIV infection confirmed, brain computed tomography (CT) findings were compatible with cerebral upon admission. Patients received...
Background. Chemokine and chemokine-receptor polymorphisms have been associated with protection against HIV infection delayed progression to AIDS, whereas in IFNλ4 (formerly IL28B) human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy (HAM) development. Evolutionary selection ancestral genes differs among populations, resulting varying risks of acquiring developing viral diseases. Methods. DNA samples from 434 patients infected HIV-1 and/or co-infected HTLV-1/-2, 74 HTLV non-infected...