A5062984994- Dementia and Cognitive Impairment Research
- Heart Failure Treatment and Management
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Mind wandering and attention
- Health, Environment, Cognitive Aging
- Medication Adherence and Compliance
- Takotsubo Cardiomyopathy and Associated Phenomena
- Congenital Ear and Nasal Anomalies
- Cardiovascular and Diving-Related Complications
- Cognitive Abilities and Testing
- Microplastics and Plastic Pollution
- Poxvirus research and outbreaks
- Cardiovascular Syncope and Autonomic Disorders
- Alzheimer's disease research and treatments
- Heart rate and cardiovascular health
- Hepatitis Viruses Studies and Epidemiology
- Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Herpesvirus Infections and Treatments
Hospital de São João
2022-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
University of Lisbon
2013-2024
Institute for Biotechnology and Bioengineering
2024
Instituto Politécnico de Lisboa
2024
Centro de Genética Clínica
2024
University of Helsinki
2011-2012
Helsinki University Hospital
2012
Medical University of Graz
2012
Hospital de Santa Maria
1999-2011
In cerebral small vessel disease, the core MRI findings include white matter lesions (WML) and lacunar infarcts. While clinical significance of WML is better understood, contribution lacunes to rate cognitive decline has not been established. This study investigated whether incident on determine longitudinal change in elderly subjects with WML.Within Leukoaraiosis Disability Study (LADIS), 387 were evaluated repeated neuropsychological assessment at baseline after 3 years. Predictors global...
<b>Objective:</b> We aimed to study if age-related white matter changes (WMC) and vascular risk factors were predictors of cognitive decline in elderly subjects with WMC living independently. <b>Methods:</b> The Leukoaraiosis Disability prospective multinational European (LADIS) evaluates the impact on transition independent into disability. Independent enrolled due presence WMC. Subjects evaluated yearly during 3 years a comprehensive clinical protocol neuropsychological battery....
<h3>Background and purpose:</h3> Age related white matter changes (ARWMC) are frequent in non-demented old subjects associated with impaired cognitive function. Our aim was to study the influence of vascular risk factors ARWMC on neuropsychological performance an independent elderly population, see if impair cognition addition effects ARWMC. <h3>Methods:</h3> Independent subjects, aged 65–84 years, any degree were assessed using a comprehensive battery including Mini-Mental State Examination...
Objective: To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical subcortical atrophy, white matter lesion (WML) volume in longitudinal cognitive performance. Methods: A total 477 subjects with age-related WML were evaluated brain MRI annual neuropsychological examinations 3-year follow-up. Baseline determinants decline analyzed linear mixed models controlling for multiple confounders. Results: MTA predicted significantly steeper...
To investigate the cognitive capacities of a cohort ischaemic or haemorrhagic stroke survivors and to identify clinical determinants post‐stroke impairment, we evaluated 237 patients admitted Stroke Unit (mean age 59; SD=12.7). Three months after stroke, were submitted neuropsychological evaluation that included Mini‐Mental State Examination (MMSE), complementary battery assess specific domains, Hamilton Depression Rating Scale (HDRS) Blessed Dementia (BDS). Disturbed performance on at least...
<h3>Objectives:</h3> In cerebral small vessel disease, white-matter hyperintensities (WMH) and lacunes are both related to cognition. Still, their respective contribution in older people remains unclear. The purpose of this study is assess the topographic distribution determine whether it has an impact on cognitive functions a sample non-disabled patients with age-related changes. <h3>Methods:</h3> Data were drawn from baseline evaluation LADIS (Leucoaraioisis Disability study) cohort...
Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific functions.To investigate the role of regional mental speed, attention and executive functions subjects age-related white matter hyperintensities (WMH).In Leukoaraiosis Disability Study, 567 WMH were examined a detailed neuropsychological assessment quantitative magnetic resonance imaging. The relationships total...
Abstract Background: Increased levels of platelet distribution width (PDW) can predict cardiac death and infarction recurrence in acute myocardial infarction. PDW appears to be a prognosis marker heart failure (HF); however, its impact on chronic HF is still unknown. We investigated the HF. Methods: retrospectively analyzed outpatients with left ventricular systolic dysfunction (LVSD) from January 2012 May 2018. Patients no data or preserved recovered ejection fraction were excluded. The...
In heart failure (HF), lower total cholesterol (TC) levels associate with poor outcomes. Whether TC variations portend prognostic implication is unknown. We aimed to evaluate the impact of variation in HF. retrospectively analyzed adult outpatients chronic HF systolic dysfunction evaluated between January/2012 and December/2020. Patients no measurement at baseline or 1-year follow-up visit were excluded. Variation during first year = [(baseline - visit)/baseline TC] × 100. followed-up until...
<h3>Objectives:</h3> To determine whether self-perceived memory impairment is associated with the severity of white matter changes (WMC) and related to cognitive impairment. <h3>Methods:</h3> Data were drawn from multinational Leukoaraiosis Disability Study (LADIS), which investigates impact WMC on global functioning. was rated using Fazekas scale. Medial temporal lobe atrophy (MTA) scored visually mean values calculated. The neuropsychological battery consisted Mini-Mental State...
In patients with established heart failure (HF) low total cholesterol levels associate worse prognosis. Evidence concerning the impact of Low-density lipoprotein (LDL-c) in HF is scarce. We aimed to evaluate prognostic LDL-c HF, both and without diabetes mellitus (DM). retrospectively analyzed outpatients chronic systolic dysfunction followed our clinic from January/2012 May/2018. was calculated using Friedewald's formula. Patients a complete lipid profile were excluded. The endpoint under...
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial, venous, or microvascular thrombosis, pregnancy morbidity, non-thrombotic manifestations in patients with persistent antiphospholipid antibodies (aPL). Catastrophic APS rare and severe form of that defined the presence multiple vascular occlusive events. When patent foramen ovale (PFO) present, paradoxical embolization can occur, simultaneously leading to arterial venous thrombosis. We present complex...
The prognostic implications of using benzodiazepines (BZD) in heart failure (HF) patients are still unknown.This study aimed to assess the association BZD use with all‑cause death ambulatory, chronic HF patients.We investigated a retrospective cohort ambulatory left ventricular systolic dysfunction (LVSD). were followed up from their first medical appointment until January 2021 and mortality was primary end point. Cox regression analysis used between mortality. Subgroup analyses performed...
Common variable immunodeficiency (CVID) is a primary disorder characterized by impaired B cell differentiation and defective immunoglobulin production. This condition often presents with wide range of clinical manifestations, including increased frequency severity infections, autoimmune diseases, inflammatory disorders, which can lead to delays in diagnosis. Granulomatous involvement the brain an extremely rare but severe manifestation CVID. We present case woman her 30s history Evans...
ABSTRACT We report the genome sequence of Lentilitoribacter sp. strain EG35 isolated from octocoral Eunicella gazella sampled off coast Portugal. reveal coding potential for biosynthesis polyhydroxyalkanoates — biodegradable polyesters that may serve bioplastics production, diverse homoserine lactone-like communication signals, and four putatively novel natural products.
Patients with heart failure (HF) often have multiple cardiovascular risk factors (CVRF) and comorbidities (CMB). We evaluated the impact of additive CMB CVRF in HF prognosis.
Introduction: Hyperuricemia (HU) is associated with an increased risk of incident heart failure (HF) and adverse HF outcomes. Patients diabetes mellitus (DM) have a greater prevalence HU. Aims: We evaluated the prognostic impact HU in patients according to coexistence DM. Methods: A retrospective cohort study ambulatory left ventricular systolic dysfunction (LVSD) was conducted from January 2012 May 2018. The end point all-cause mortality; follow-up until 2021. Cox regression analysis used...
Aims: Depressive symptoms (DS) in the elderly have been implicated cognitive decline, and are more frequent patients with white matter changes (WMC). Our aim was to ascertain if DS influence cognition an population WMC. Methods: The LADIS (Leukoaraiosis Disability) is a prospective European study that evaluates impact of WMC on transition independent subjects into disability. Subjects were enrolled due minor complaints without daily-living activities, presence evaluated at baseline yearly...
Orthostatic hypotension (OH) is a fall in systolic blood pressure (BP) > = 20 mmHg or diastolic BP 10 the 3 minutes after standing. OH associated with falls, cognitive impairment and cardiovascular disease. Hospitalized patients may be particularly prone to vulnerable its consequences due acute illness, prolonged bed rest drug treatment. We aimed evaluate prevalence of at discharge, determine characteristics these understand if positive test (+OHt) was worse outcomes.Retrospective analysis...
Abstract Background Heart failure (HF) hospitalizations foreshadow a very gloomy outcome. In the first 3 months, vulnerable period, mortality is around 10% and 28% of patients die in first-year post hospitalization. Reports on 10-year survival are scarce. Purpose We assessed rate 21st century cohort acute HF studied predictors. Methods that were included an registry between March 2009 December 2010. All hospitalized Internal Medicine Ward with primary diagnosis eligible. Both left...