After abdominal surgery, there is a possibility of adhesions between the organs and wall. Theadhesions can lead to problems such as chronic pain, intestinal blockage, infertility. To prevent adhesion, antiadhesion patchescan be used. In this study, poly hydroxybutyrate-co-hexanoate membranes were fabricated patches modified witheither fatty acids or polyethylene glycol. The homogeneity protein absorption assessed. effects onblood coagulation factors determined adhesion-proliferation...

The aim of this study is to develop and analyze dexamethasone-loaded poly hydroxybutyrate-stearic acid blend nanoparticles for the treatment non-bacterial uveitis. Uveitis a chronic inflammatory eye disease responsible 10-15% global blindness. While repeated intravitreal steroid injection successful strategy, it has drawbacks such as cataracts retinal detachment. Serious side effects high costs caused by recurrent infections are important limiting factors. Controlled release systems...

The hydrogel is a biopolymer exhibiting swelling behaviour involving significant amount of water due to its insoluble, three-dimensional network structure when exposed the aqueous medium, and allows use in wound dressings. In present study, was synthesized from chitosan carboxymethylcellulose (CMC) polymers as result chemical reaction at which N,N'-methylenebisacrylamide (MBA) used cross-linker ammonium persulfate (APS) initiator-catalyst. Characteristic features were determined by FTIR...

This study aimed to address a significant challenge in the application of bacterial cellulose (BC) within tissue engineering and regenerative medicine by tackling its inherent insolubility water organic solvents. Our team introduced groundbreaking approach utilizing zinc sulfate (ZnSO

Abstract The treatment of skeletal muscle, which lost its function with damage or trauma autologous muscle tissue transfer, is a very problematic approach. Hence, it critical to develop materials that are mimicking mechanical behaviors and allowing cell adhesion. Polyurethanes (PUs) one the most common polymers in engineering applications regeneration due their elasticity flexibility. Clinoptilolite (CLN) hydrated alumina silica crystal based biocompatible material numerous positive effects...

Vitamin D3 (VitD3) has several beneficial effects on many metabolic pathways such as immunity system, bone development. The aim of the study, encapsulation VitD3 with solid lipids, determine efficiency and biocompatibility nanoparticles. Therefore, VitD3-loaded lipid nanoparticles (SLNPs) were developed by optimising ratios VitD3, stearic acid, beeswax sodium dodecyl sulphate (SDS). Thermal stability, degradation profile, crystallinity rate, release profile SLNPs determined. Cytotoxicity...

The excessive collagen type I accumulation in the extracellular matrix leads to scar formation. We aimed develop a biomaterial for scarless tissue regeneration by suppressing overexpression, and stimulation of III expression. Alginate (Alg) is widely used natural material biomedical applications, humic acid (HA) macromolecule with antioxidant, anti-inflammatory properties. Humic alginate were cross-linked obtain hydrogel membrane. cell viability Acid-Alginate (HA-Alg) on L929, HaCaT,...

Induced pluripotent stem cells (IPSC) are preferred as an alternative source for regenerative medicine, disease modeling, and drug screening due to their unique properties. As seen from the previous studies in literature, most of vector systems transfer reprogramming factors viral-based have some well-known limitations. This study aims develop a non-viral system transfection factors. Cationic stearamide lipid nanoparticles (CSLN) were prepared via solvent diffusion method. The obtained CSLNs...

"Currently, there is a considerable clinical demand for biocompatible and robust tissue-engineered artificial vascular graft materials. The application requiring adequate mechanical strength biocompatibility still lags at some critical points. Bacterial cellulose (BC) well known its use as biomaterial in various fields due to high biocompatibility. most issue preventing the wide of BC 3D printing insolubility water organic solvents. Because this feature, bioink limited. In study, optimizing...

Monosized cationic nanoparticles were produced by emulsifier-free emulsion polymerization of styrene, poly(ethylene glycol) methacrylate and N-[3-(dimethyl-amino) propyl] methacrylamide, conducted in the presence a initiator, 2,2′-azobis (2-methylpropionamidine) dihydrochloride, using different amounts ingredients at conditions. The structure terpolymers was confirmed 1H-NMR FTIR spectroscopy. nanoparticles, with an average size 71.3 nm [polydispersity index (PDI), 1.110] Zeta potential 65.6...

In the treatment of dermal wounds, wound-dressing materials prepared from natural mucopolysaccharides are widely used because their advantages such as nonirritation, nontoxicity, and ease in topical application. present study, alginate hydrogels modified with N-acetyl glucose amine (NAG) were material. Physical, chemical, thermal, mechanical properties studied. Cytotoxicity on endothelial (HUVEC) keratinocyte (HaCaT) cells examined. Anti- proinflammatory cytokine levels human...

Decellularized tissues and organs have been successfully used in various tissue engineering regenerative medicine applications. A biological scaffold obtained from the extracellular matrix can be produced by a variety of decellularization methods that effectively remove cells to treated. Decellularization is changed according target structure organs. These summarized with chemically, physically, enzymatically using Supercritical Fluid Extraction (SFE) ways. Each these affects biochemical...

In recent years, nanoparticle systems have been frequently used as non-viral carriers for the treatment of genetically based diseases and cancer. However, conjugate formation should be optimized by selecting a suitable carrier transport each genetic material desired to transported target cell. A created taking into account size zeta potential electrical characteristics cargo being transported. Nanocarrier can protect package material. Calcium phosphate nanoparticles (CaP NPs) with unique...

The first case is described in Wuhan city of China December 2019 and the disease (COVID-19) continues to pose threat global health all over world affecting more than approximately 476 million confirmed cases 6 deaths. Reliable effective methods are taken a critical role such as real-time reverse transcriptase (RT)-PCR test gold standard method, serological tests, loop-mediated isothermal amplification (RT-LAMP) method chosen firstly.

In the study, we aimed to develop a multipurpose tissue patch for repairment of various defects. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was blended with paraffin wax, and chemical composition membranes determined by FTIR RAMAN spectroscopy. The surface area PHBHHx PHBHHx/Paraffin wax were as (38,79 m2/g) (81,108 m2/g), respectively. DMA DSC results revealed that blending increased percentage elongation membrane 7,6% reduced modulus elasticity. While at break 22,463%...

BACKGROUND: Bioengineering products can help bone tissue regeneration. OBJECTIVE: There is an ongoing research for more effective biomaterials in Chitosan (Ch) grafted stearic acid (Ch-g-Sa) polymer was synthesized and its usability as a putty evaluated this study. METHODS : The chemical structure of Ch-g-Sa investigated using Proton nuclear magnetic resonance (H-NMR) Fourier-transformed infrared spectroscopy-attenuated total reflectance (FTIR-ATR). Thermal properties were determined by...