A5086818708- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Kruppel-like factors research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Telomeres, Telomerase, and Senescence
- Protein Kinase Regulation and GTPase Signaling
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Genomic variations and chromosomal abnormalities
- Gold and Silver Nanoparticles Synthesis and Applications
- Mechanisms of cancer metastasis
- Endoplasmic Reticulum Stress and Disease
- Animal Genetics and Reproduction
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
Bilkent University
2004-2016
Institute of Cancer Research
1998-2000
St Mary's Hospital
1994-1996
Imperial College London
1994-1996
St. Mary's Hospital
1993-1995
University College London
1994
Hospital for Sick Children
1994
Zimmer Biomet (United Kingdom)
1994
The Honourable Society of Lincoln's Inn
1994
Ag–Cu nanoalloys were synthesized by chemical co-reduction of their metal salts in aqueous solution with hydrazine hydrate, the presence complexing agent and stabilizer, preventing oxidation copper, as revealed XPS. Their antibacterial behavior was tested against Escherichia coli strains, attesting far better ability compared to Ag-only nanoparticles.
Quantitative gene expression measurements from tumor tissue are frequently compared with matched normal and/or adjacent for diagnostic marker selection as well assessment of the degree transcriptional deregulation in cancer. Selection an appropriate reference (RG) or RG panel, which varies depending on cancer type, molecular subtypes, and tissues used interindividual calibration, is crucial accurate quantification expression. Several panels have been suggested breast making comparisons among...
CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor silencing various types cancers. It usually occurs at early steps cancer progression and can be detected easily, giving rise to development promising biomarkers for both detection cancer, including breast cancer. 5-aza-2'-deoxycytidine (AZA) DNA demethylating anti-cancer agent resulting induction genes suppressed via hypermethylation.Using microarray expression profiling AZA- or DMSO-treated non-tumorigenic...
Tumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with intrinsic control of number cell divisions in human somatic tissues by a mechanism called senescence. Replicative immortality acquired inactivation p53 and p16 INK4a genes reactivation hTERT gene expression. It unknown whether cancer reversible. Here, we show spontaneous induction senescence p53-and -deficient hepatocellular carcinoma cells. phenomenon...
Journal Article An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4 Get access Isik G. Yulug, Yulug 1Department Biochemistry Molecular Genetics, St Mary's Hospital Medical School, Imperial CollegeNorfolk Place, London W2 1PG Search other works by this author on: Oxford Academic PubMed Google Scholar Nicholas Katsanis, Katsanis Jacqueline de Belleroche, Belleroche 3Department Biochemistry, Charing Cross Westminster SchoolFulham Palace Road, SW6, UK John...
Background Breast cancer is a remarkably heterogeneous disease. Luminal, basal-like, "normal-like", and ERBB2+ subgroups were identified shown to have different prognoses. The mechanisms underlying this heterogeneity are poorly understood. In our study, we explored the role of cellular differentiation senescence as potential cause heterogeneity. Methodology/Principal Findings A panel breast cell lines, isogenic clones, tumors used. Based on their ability generate senescent progeny under...
Abstract Background Basal cell carcinomas ( BCC s) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of NM 23‐ H 1, NDRG E ‐cadherin, RHOGDI 2, CD 82/ KAI MKK 4, and AKAP 12 metastasis suppressor proteins s. Methods A total 96 10 normal samples were included for immunohistochemical study. Eleven frozen also studied by quantitative real time polymerase chain reaction qRT ‐...