Hai-liang Xu

ORCID: 0000-0001-9150-9678
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About
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Research Areas
  • Geotechnical and Geomechanical Engineering
  • Methane Hydrates and Related Phenomena
  • Belt Conveyor Systems Engineering
  • Hydraulic and Pneumatic Systems
  • Oil and Gas Production Techniques
  • Geotechnical Engineering and Underground Structures
  • Cavitation Phenomena in Pumps
  • Spacecraft and Cryogenic Technologies
  • Offshore Engineering and Technologies
  • Mechanical stress and fatigue analysis
  • Industrial Engineering and Technologies
  • Drilling and Well Engineering
  • Hydraulic Fracturing and Reservoir Analysis
  • Coal Combustion and Slurry Processing
  • Vibration and Dynamic Analysis
  • Gear and Bearing Dynamics Analysis
  • Fluid Dynamics Simulations and Interactions
  • Tunneling and Rock Mechanics
  • Industrial Technology and Control Systems
  • Coronary Interventions and Diagnostics
  • Hydrocarbon exploration and reservoir analysis
  • Statistical Methods in Clinical Trials
  • Structural Integrity and Reliability Analysis
  • Pharmacogenetics and Drug Metabolism
  • Aquatic Invertebrate Ecology and Behavior

Zhejiang University
2024

Central South University
2011-2023

State Key Laboratory of High Performance Complex Manufacturing
2011-2022

Jiangsu Province Hospital
2019

Nanjing Medical University
2011-2019

Hunan University of Humanities, Science and Technology
2019

Nanjing University of Posts and Telecommunications
2014

Vanderbilt University
2011-2012

Routine integration of genotype data into drug decision making could improve patient safety, particularly if many relevant genetic variants can be assayed simultaneously before prescribing the target drug. The frequency opportunities for pharmacogenetic and potential adverse events (AEs) mitigated are unknown. We examined with which 56 medications known outcomes influenced by variant alleles were prescribed in a cohort 52,942 medical home patients at Vanderbilt University Medical Center...

10.1038/clpt.2012.66 article EN Clinical Pharmacology & Therapeutics 2012-06-27

Variants in ABCB1 and CYP2C19 have been identified as predictors of cardiac events during clopidogrel therapy initiated after myocardial infarction (MI) or percutaneous coronary intervention (PCI). In addition, PON1 has recently associated with stent thrombosis. The reported effects these variants not yet replicated a real–world setting. We used BioVU, the Vanderbilt DNA repository linked to de–identified electronic health records (EHRs), find data on patients who were treatment an MI and/or...

10.1038/clpt.2011.221 article EN Clinical Pharmacology & Therapeutics 2011-12-21

Liquid–gas and liquid–solid phase relationships are established in this study using the theories of cavitation nucleation solid–liquid two-phase flow, respectively. The relationship between gas solid phases is then derived, effect parameter characteristics on slurry-conveying slurry pump analyzed. influence law particle concentration speed airing performance two-stage pumps studied basis computational fluid mechanics. Results show that phenomenon reduces overall pressure flow field deep-sea...

10.1063/1.5125800 article EN cc-by AIP Advances 2019-10-01

The work simulates the transport pipeline movement of marine dynamic environment based on computational fluid dynamics research method. present also studies influence solid–liquid two-phase flow field in pipeline. An experimental study hydraulic law natural gas hydrate is performed platform deep-sea mining metallogenic system fluctuation. Results show a large disturbance transverse swing convection pipelines and small axial vibration. distribution characteristics conveyor are consistent with...

10.1080/19942060.2020.1727774 article EN cc-by-nc Engineering Applications of Computational Fluid Mechanics 2020-01-01

For the sake of guiding parameter setting hydraulic lifting pipeline system for cutter-suction mining natural gas hydrates ("hydrates" short) on seabed, decomposition characteristics in pipelines and effects flow parameters were studied this paper. A temperature–pressure model hydrate pipeline, a mass transfer multiphase established using mathematical modeling method according to thermodynamics fluid mechanics. Then, relationships temperature pressure fluid, amount particulate matter surface...

10.1016/j.ngib.2018.07.005 article EN cc-by-nc-nd Natural Gas Industry B 2019-03-20

10.1007/s11771-015-2906-y article EN Journal of Central South University 2015-09-01

The flow fields of chip removal from the impactor's exhaust hole to its rear head were established study cuttings carrying characteristics back-reaming pneumatic impactor by utilizing computational fluid dynamics theory and simulation software Fluent. Based on structure working principle impactor, gas solid two phase was simulated, field moving trajectory concentration distribution particles obtained. research shows that: once enters speed will slow down pressure gradually decrease entrance...

10.1016/s1876-3804(16)30015-5 article EN cc-by-nc-nd Petroleum Exploration and Development 2016-02-01

Abstract It is known from the principle that pump–vessel combined ore lifting method has high head, large ores capacity, and long-term working reliability. When applied to deep-sea rigid pipe mining system, main pump power equipment installed on ship more convenient operate maintain. According Bernoulli’s equation two phases of hydrodynamics theory, parameters have been calculated analyzed. head H 1000m sea system 124–172m 5000m 652–760m. feasible in both theory practice, therefore it an...

10.1115/1.2427070 article EN Journal of Offshore Mechanics and Arctic Engineering 2008-02-01

10.1007/s11771-012-0983-8 article EN Journal of Central South University 2012-01-01

Abstract To analyse the motion response of mining vessel under complex sea conditions and provide theoretical support for design heave compensation system, hydrodynamic analysis software AQWA three-dimensional potential flow theory was used to time-frequency characteristics coupling wind, wave flow. The amplitude operator (RAO) hull at different angles six-degree-of-freedom currents were obtained. results show that angle has an influence on Rao in six degrees freedom, but frequency...

10.1088/1742-6596/1300/1/012010 article EN Journal of Physics Conference Series 2019-08-01

10.1007/s11771-008-0102-z article EN Journal of Central South University of Technology 2008-08-01

How to theoretically describe the process of turbulence formation emains an unsolved problem. A new method is presented in this paper for quantitatively researching phase transition based on a dimensionless and catastrophe theory. Then, formula energy spectrum density Ek, with wave number time-scale index strictly derived from folding model, can explain turbulent system, inherited large eddies transferred small until viscous dissipation occurs, physically. As example, solid–liquid two-phase...

10.1080/19942060.2019.1711197 article EN cc-by Engineering Applications of Computational Fluid Mechanics 2020-01-01

Temporal integration is crucial for auditory perception, yet the mechanisms underlying its role are not fully elucidated. This study examines perceptual discrimination of click trains with varied temporal configurations to determine if they can be perceived as distinct objects, potentially introducing a novel dimension sound perception. In humans, psychological experiments using delayed match-to-sample task revealed that participants could distinctly discriminate between different...

10.1101/2024.12.02.626513 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-12-04
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