The vast domain of regenerative medicine comprises complex interactions between specific cells' extracellular matrix (ECM) towards intracellular formation, its secretion, and modulation tissue as a whole. In this domain, engineering scaffold utilizing biomaterials along with cells formation living tissues is immense importance especially for bridging the existing gap late; nanostructures are offering promising capability mechano-biological response needed regeneration. Materials selected...

Super-paramagnetic iron oxide nanoparticles (SPIONs) have multiple theranostics applications such as T2 contrast agent in magnetic resonance imaging (MRI) and electromagnetic manipulations biomedical devices, sensors, regenerative medicines. However, SPIONs suffer from the limitation of free radical generation, this has a certain its applicability tissue regeneration applications. In current study, we developed simple hydrothermal method to prepare carbon quantum dots (CD) doped (FeCD)...

The study conducts a comparative analysis between two prominent methods for fabricating composites bone scaffolds-the (solid) solvent method and the solvent-free (melting) method. While previous research has explored these individually, this provides direct comparison of their outcomes in terms physicochemical properties, cytocompatibility, mechanical strength. We also analyse workflow scalability potentials. Polycaprolactone (PCL) hydroxyapatite (HA) were prepared using (chloroform) melting...

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by impaired insulin secretion, sensitivity, and hyperglycemia. Diabetic wounds are one of the significant complications T2DM owing to its difficulty in normal healing, resulting wounds. In present work, PCL/PVA, PCL/PVA/PCL, metformin-loaded, PCL/PVA-Met PCL/PVA-Met/PCL hybrid scaffolds with different designs were fabricated using 3D printing. The porosity morphological analysis 3D-printed performed scanning electron...

Critical bone defects with a sluggish rate of auto-osteoconduction and imperfect reconstruction are motivators for the development an alternate innovative approach regeneration bone. Tissue engineering signifies advanced way to overcome this problem by creating additional tissue substitute. Among different fabrication techniques, 3D printing technique is obviously most efficient fabricate osteoconductive scaffold controlled porous structure. In current article, polycarbonate polyester diol...

Cervical atresia is a rare congenital Müllerian duct anomaly that manifests as the absence or deformed nonfunctional presence of cervix. Herein, multi-layered biodegradable stent fabricated using homogeneous blend silk fibroin with polycaprolactone hexafluoroisopropanol common solution. Briefly, concentric cylinder 3D honeycomb layer sandwiched within electrospun sheets for fixing at cervico-uterine junction to pave way cervical reconstruction. An average length 40 mm 3 diameter hybrid...

Small organic luminogens, owing to their contrasting stimuli-responsive fluorescence in solution along with strong emission aggregated and solidstates, have been employed optoelectronic devices, sensors, bioimaging. Pyrene derivatives usually exhibit concentration-dependent excimer/aggregate solution. However, the impacts of microenvironments on monomer aggregate bands relative intensities solution, solid, supramolecular aggregates are intriguing. The present study delineates a trade-off...

High SF loaded-PCL electrospun fiber with core-shell morphology promotes epithelialization accelerated wound healing.

Dense Porous multilayer ceramic structures were fabricated using a simple novel dough process for the first time, where hydrophobic was mixed with hydrophilic porogen like salt to form porous structure. and mixture processed in ambient atmosphere layered green state before drying. Salt leaching removal performed warm water followed by binder burnout sintering. Micro CT electron microscopy revealed an intimate contact at interface 51–63 ​Vol% porosity layer achieved 44–48% open porosity....

Adolescent idiopathic scoliosis (AIS) is a noticeable spinal deformity in both adult and adolescent population. In majority of the cases, gold standard treatment surgical intervention. Technological advancements medical imaging 3D printing have revolutionised planning intraoperative decision making for surgeons surgery. However, its applicability complex surgeries poorly documented with human subjects. The objective this study to evaluate accuracy printed models deformities based on Cobb...

Epilepsy is a medical condition that causes seizures and impairs the mental physical activities of patients. Unfortunately, over one-third patients do not receive adequate relief from oral Antiepileptic Drugs (AEDs) continue to experience seizures. In addition that, long term usage can cause range side effects. To overcome this problem, precision 3D printing technology combined with controlled release capabilities biodegradable polymers, allowing for tailored localized AED delivery specific...

Implant stability significantly impacts accelerated osseointegration, leading to faster patient recovery. Both primary and secondary necessitates superior bone-implant contact influenced by the surgical tool required prepare final osteotomy site. Besides, excessive shearing frictional forces generate heat causing local tissue necrosis. Hence, procedure proper irrigation with water minimize generation. Notably, system removes bone chips osseous coagulums, which may help accelerate...

Calcium phosphate (CaPs)-based nanostructures are mostly known to induce osteogenic differentiation of mesenchymal stem cells (MSCs). However, in the current study, doping carbon quantum dots into calcium nanorods (C-CaPs) has been observed affect pathway and enhanced expression chondrogenic genes instead ones. Here, we report a microwave-assisted single-step synthesis dot their ectopic chondrogenicity rodent subcutaneous model. High-resolution transmission electron microscopy, X-ray powder...

The extent to which load transfer in a diseased mandible with odontogenic tumour might influence the potential risk of pathological fracture has scarcely been investigated. study sought investigate quantitative deviations across healthy and cancer-affected (diseased) mandibles having tumours. effect size tumours (small: 9 mm diameter, large: 19 diameter), variation bone mechanical (elastic) properties on during mastication cycle have Based patient-specific computed tomography–scan datasets,...

Reconstruction of segmental defects are popularly approached with surface engineered additively manufactured scaffolds owing to its enhanced post-surgery tissue integration properties. The present work is aimed at fabrication Ti lattice structures using 3D printing, a novel approach silane chemistry-based modification those Ti-surfaces osteogenic peptides (OGP). 0.6 mm strut-diameter having 0.5 inter-strut distance were chosen for an extrusion-based printing. Based on the evidence, it could...

In modern civilization with fast work culture and uncontrolled lifestyles increase bone-related problems, moreover lack of auto-regeneration bone, indulge to formulate a suitable methodology get rid this problem. article, nanohydroxyapatite (nHA) decorated hierarchical titanium phosphate (TP) was synthesized by solvothermal process. The prepared hybrid nanofiller (TP-nHA) combined into newly tartaric acid-based polyurethane (PU) through in situ technique. porous 3D scaffold fabricated...

Abstract The fixation of common mandibular subcondylar fractures is associated with a high complication rate, and the decision suitable plate design material still remains challenge. Computational models have been developed verified for understanding fracture fixation, but most investigation has limited to simplified model, single force evaluation plate-only designs. Using finite elements, we analysed stability five materials -Nitinol, Magnesium alloys, two types Titanium alloys (Ti-6Al-4V...