A5047826716- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Hemoglobinopathies and Related Disorders
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Advances in Oncology and Radiotherapy
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vitamin C and Antioxidants Research
- Global Cancer Incidence and Screening
- Hematopoietic Stem Cell Transplantation
- Venous Thromboembolism Diagnosis and Management
- Erythropoietin and Anemia Treatment
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
Yale Cancer Center
2022-2025
Yale University
2022-2025
Yale New Haven Health System
2024
Yale New Haven Hospital
2024
Einstein Medical Center Philadelphia
2016-2020
Brigham and Women's Hospital
2015-2017
Klinikum Ludwigshafen
2015
Harvard University
2015
Background. Invasive fusariosis remains an aggressive, albeit infrequent infection in immunocompromised patients. Methods. We identified all cases of invasive between January 2002 and December 2014. recorded patient characteristics including clinical presentation, treatment, outcomes at 6 12 weeks after diagnosis, as well species identification antifungal drug susceptibilities. Results. Fifteen patients were diagnosed with proven (12, 80%) or probable (3, 20%) fusariosis. Median age was 60...
Abstract Acquired aplastic anemia (AA) is an immune-mediated disorder leading to bone marrow failure characterized by pancytopenia, with infectious and bleeding complications. The disease course may be complicated paroxysmal nocturnal hemoglobinuria (PNH), necessitating screening flow cytometry (FC) at the time of AA diagnosis. Management strategies vary based on severity. Severe patients are usually heavily transfusion-dependent (HT-AA) typically treated antithymocyte globulin, calcineurin...
Abstract Background Polycythemia vera (PV) and essential thrombocythemia (ET) are linked to increased risk of cardiovascular morbidity mortality. In addition the reduction in arterial thrombotic events, statins may prevent venous thrombosis including among patients with cancer. As previous registry‐ claims‐based studies revealed that use improve survival various malignancies we evaluated their impact on outcomes older adults PV ET. Methods We identified 4010 (aged 66–99 years at diagnosis) (...
Patients with classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary secondary myelofibrosis (MF), are known to have an increased risk of second malignancies (SMs). Hydroxyurea (HU) is a guideline-recommended cytoreductive therapy for patients at high MPNs. Controversy exists as whether HU use associated higher SMs, acute myeloid leukemia (AML) myelodysplastic syndrome (MDS). We conducted...
With approximately 750 cases reported, Erdheim-Chester disease is an exceedingly rare histiocyte cell disorder. Affected sites typically include long bones, large vessels and central nervous system. However, cutaneous pulmonary involvement can also occur. The diagnosis ascertained by identification of foamy histiocytes positive for CD68, CD163, factor XIIIa on immunoperoxidase staining. Recently published literature have described association between BRAF V600E mutation. This finding...
The FLT3 inhibitor quizartinib has been shown to improve overall survival when added intensive induction chemotherapy ("7 + 3") in patients 18-75 years old with newly diagnosed AML harboring a FLT3-ITD mutation. However, the health economic implications of this approval are unknown. We evaluated cost-effectiveness using partitioned analysis model. One-way and probabilistic sensitivity analyses were conducted. In base case scenario, addition 7 3 resulted incremental costs $289,932 compared...
We investigated immune cytopenia in multiple myeloma (MM) patients with concurrent acquired aplastic anemia (AA), focusing on three clinical cases treated plasma cell-directed therapy. All achieved partial response MM and one patient experienced complete resolution of AA. Two had improvement transfusion requirement but continued to suffer from severe AA, leading immunosuppressive therapy (IST) both patients.
Clinical trials are crucial for improving patient outcomes. Although a significant number of discontinued prematurely, our understanding factors influencing early termination is limited. We conducted comprehensive search ClinicalTrials.gov to identify leukemia from 2000 2020, followed by data abstraction performed two independent reviewers. Among 3522 clinical identified, 28.4% were terminated prematurely. Slow accrual was the leading cause 38.2%. The rate increased significantly 17.0%...
Venous thromboembolism (VTE) is a major cause of mortality and morbidity in hospitalized patients with malignancy. Nationwide Inpatient Sample database was analyzed to determine the trends rate hospitalization from VTE ovarian cancer assess its economic impact resource utilization.We queried 2003 2011 Healthcare Cost Utilization project (Agency Research Quality) identify all adults (age ≥18 years) cancer. Patients as one top 3 discharge diagnoses were also identified. Demographic...
Severe malaria is an uncommon diagnosis in the United States. However, awareness of signs, symptoms, and treatment options imperative order to promptly initiate optimal therapy. False positive human immunodeficiency virus (HIV) results are rare setting acute infection with introduction newer fourth-generation immunoassays. The Centers for Disease Control algorithms assist confirming true HIV (Branson et al. 2014).
Abstract Tyrosine kinase inhibitor (TKI) use is critical in the care of patients with chronic myeloid leukemia (CML). Quantitative polymerase chain reaction (qPCR) testing for BCR-ABL1 every 3 months during first year TKI treatment recommended to assure achievement milestone response goals. Real-world evidence patterns qPCR monitoring and adherence older patient population lacking. Using Surveillance, Epidemiology, End Results–Medicare database, we identified 1192 aged ≥66 years (median age,...
We evaluated the potential role of birth characteristics in etiology early-onset meningioma.Leveraging a population-based linkage California records (from 1978 to 2015) and cancer registry data 1988 2015), we identified 362 nonmalignant meningioma cases aged 0-37 years selected 18 100 controls matched on year birth. Cases were compared with regard characteristics, adjusted odds ratios (ORs) 95% confidence intervals (CIs) estimated from unconditional multivariable logistic regression models....
9031 Background: Each hematology and oncology (H/O) fellowship program has a unique educational curriculum. Best practices about how to structure the curricula in H/O programs are limited. Here, we provide results of multicenter assessment understand differences didactic curricula. Methods: fellows were recruited via email be site coordinators (SC) for study investigating experiences. In total, identified SCs at 27 who enrolled with leadership approval. SC received REDCAP survey which they...