Introduction: Some conflicting results of the efficacy inducibility test used in catheter ablation atrial fibrillation (AF) have been reported. The aim this study was to investigate and circumferential with pulmonary vein isolation (PVI) patients paroxysmal AF its relationship substrate. Methods Results: This consisted 88 who underwent ablation. Electroanatomic mapping using a NavX system performed biatrial voltage obtained during sinus rhythm. After successful PVI, an determine requirement...

Introduction: The atrial substrate plays an important role in the maintenance of fibrillation (AF). Further investigation biatrial may be helpful for understanding mechanism AF. aim this study was to investigate properties right and left (RA LA) AF patients their impact on catheter ablation. Methods: Biatrial electroanatomic mapping using a three‐dimensional system (NavX) performed 117 consecutive with paroxysmal (n = 99) persistent 18) voltage total activation time (TAT) were obtained...

Atrial substrate properties have been demonstrated to be related atrial arrhythmias. This study investigated whether the exhibits progressive remodeling in patients with recurrence of fibrillation (AF) after catheter ablation.Fifteen consecutive AF (52 +/- 12 years old, males) underwent same mapping technique (NavX, St. Jude Medical, Minnetonka, MN, USA) and ablation for primary (170 66 days first procedure). The bipolar mean peak-to-peak voltage (PPV) global left atrium during sinus rhythm...

The efficacy of ablation complex fractionated atrial electrograms (CFEs) in the single procedure for nonparoxysmal fibrillation (AF) patients is not well demonstrated. aim this study was to compare strategies pulmonary vein isolation (PVI) plus linear with and without additional ofCFEs these patients.Consecutive 60 (49 +/- 11 years old, 50 male, 10 female) AF underwent catheter guided by a NavX mapping system. A stepwise approach included circumferential PVI left (LA) followed either...

Objectives and Background: The success rate of achieving electrical isolation by circumferential pulmonary vein ablation (CPVA) varies from 32% to 88%. We carried out at the carina evaluate elimination rates potentials (PVPs) after one round CPVA had failed eliminate all PVPs in patients with atrial fibrillation (AF). Methods: Ninety‐seven (75 males; mean age: 50 ± 12 years; 15 persistent AF 82 paroxysmal AF) who underwent catheter were analyzed. All PVP as endpoint. electrophysiology...

There is a paucity of data regarding the mechanism maintaining atrial fibrillation (AF) after pulmonary vein isolation (PVI) in patients with AF. The aim this study was to examine impact circumferential PVI on left (LA) substrate characteristics.Seventy-two AF (age, 53+/-11 years) underwent mapping and catheter ablation using an NavX system. biatrial characteristics such as complex fractionated electrograms (CFEs; based intervals) frequency analysis (based dominant frequencies) were mapped...

Previous studies have indicated that atrial fibrillation (AF) in patients over the age of 60 at diagnosis is a risk factor for substantial increase cardiovascular events. However, information about impact on substrate and clinical outcome after catheter ablation AF limited.This study included 350 (53 ± 12 years, 254 males) who underwent circumferential pulmonary vein isolation (CPVI) AF, guided by NavX mapping system. The subjects were divided into three groups according to their age, as...

Background: The left atrial (LA) size is an important predictor of fibrillation (AF) procedural termination and the long‐term outcome. We sought to evaluate outcome in regard LA termination. Methods: Eighty‐seven consecutive chronic AF patients (72 males, 53 ± 10 years) underwent 3D mapping (NavX) ablation. A stepwise approach including circumferential pulmonary vein (PV) isolation, linear ablation, continuous complex‐fractionated electrogram (CFE) ablation (targeting fractionation intervals...

Atrial tachycardia (AT), including focal and reentrant AT, can occur after circumferential pulmonary vein isolation (CPVI). The aim of this study was to investigate the electrophysiological characteristics induced AT its clinical outcome.In our series 160 patients with paroxysmal atrial fibrillation (AF), 45 ATs were by high-current burst pacing CPVI in 26 patients. All mapped using a three-dimensional (3D) mapping system. Noninducibility endpoint ablation AT. Gap-related considered if...

Background: Electrical isolation of pulmonary veins (PVs) is an effective therapy for atrial fibrillation (AF). Both segmental ostial PV ablation and circumferential with PV–left (LA) block have been implicated to eliminate AF. However, the mechanism recurrent AF after undergoing either strategy remains unclear. Methods Results: Of 73 consecutive patients symptomatic that underwent had recurrences AF, Group 1 consisted 46 (age 56 ± 13 years old, 35 males) who by 2 27 51 11 24 PV–LA block. In...

Background: The atrial substrate is the determinant of occurrence and maintenance fibrillation (AF), which can induce remodeling function structure. This study investigated relationship between left (LA) properties LA mechanical function. Methods: Forty‐four consecutive patients (50.3 ± 10.7 years old, 33 men) who presented with sinus rhythm during echocardiographic before receiving catheter ablation for AF were enrolled. diameter, volume, ratio early late transmitral filling flow velocities...

Introduction: Paroxysmal supraventricular tachycardia (PSVT) is often associated with paroxysmal atrial fibrillation (AF). However, the relationship between PSVT and AF still unclear. The aim of this study was to investigate clinical electrophysiological characteristics in patients AF, demonstrate origin before radiofrequency (RF) ablation AF. Methods Results: Four hundred two consecutive (338 had a pure PV foci 64 non‐PV foci) that underwent RF were included. Twenty‐one (10 females; mean...

A second procedure for recurrent atrial fibrillation (AF) may be associated with the need a different positioning of puncture site and increase difficulty complications. This study investigated whether transseptal changed difficult punctures increased in patients who received repeat ablation AF.Twenty-nine AF (52 +/- 12 years old, 20 males) underwent catheter recurrence AF. Compared first procedure, height between coronary sinus ostium was higher during both end-systolic phase (38.0 4.7 vs....

AimsFibrillatory waves observed in the surface electrograms may be a direct reflection of electrophysiologic mechanism atrial fibrillation (AF). This study compared fibrillatory ECG and individual intracardiac mapping sites different types paroxysmal AF.

Background: The features of multiple catheter ablation procedures for paroxysmal atrial fibrillation (AF) are unknown. We aimed to investigate the electrophysiologic characteristics and clinical outcomes in patients with AF who received more than two procedures. Methods: study consisted 15 consecutive (age 48 ± 14 years, 10 males) had undergone three five (3.3 0.6) recurrent AF. Results: Ten pulmonary vein (PV)‐AF one originating from both PVs superior vena cava (SVC) first procedure. All...

Objective: Endothelin‐1 has important cardiovascular effects and is activated during atrial fibrillation. Pulmonary veins (PVs) play a critical role in the pathophysiology of The aim this study was to evaluate whether endothelin‐1 affects PV arrhythmogenic activity. Methods: Conventional microelectrodes were used record action potentials (APs) contractility isolated rabbit tissue specimens before after administration (0.1, 1, 10 nM). ionic currents cardiomyocytes investigated (10 nM) through...

The left atrial (LA) substrate plays an important role in the maintenance of fibrillation (AF). However, little is known about acute effect circumferential pulmonary vein isolation (CPVI). This study was to investigate change LA activation, voltage and P wave surface electrocardiogram (ECG) after CPVI.Electroanatomic mapping (NavX) performed 50 patients with AF (mean age = 54 +/- 10 years, 36 males) who underwent only CPVI. mean peak-to-peak bipolar total activation time were obtained during...

Background: The characteristics of cavotricuspid isthmus (CTI) in patients with atrial fibrillation (AF) and flutter that may predict recurrence is not known. We aimed to investigate the CTI who underwent a second ablation procedure for recurrent AF after previous combined pulmonary vein (PV) ablation. Methods: Among 196 consecutive drug‐refractory symptomatic PV isolation bidirectional block, 49 (age 50 ± 12 years, 43 males) had received 291 241 days first procedure. Right angiography...

CFAEs and the Voltage. Introduction: Catheter ablation of atrial fibrillation (AF) can be guided by identification complex fractionated electrograms (CFAEs). We aimed to study prediction defined an automatic algorithm in different substrates (high voltage areas vs low areas). Methods Results: This included 13 patients (age = 56 ± 12 years, paroxysmal AF 8 persistent 5), who underwent mapping catheter with a NavX system. High‐density left atrium (LA) was performed during sinus rhythm (SR)...

Long QT syndromes (LQTS) are characterized by prolonged QTc interval on electrocardiogram (ECG) and manifest with syncope, seizures or sudden cardiac death. 1-3 constitute about 75% of all inherited LQTS. We classified a cohort Indian patients for the common LQTS based T wave morphology triggering factors to prioritize gene be tested. sought identify causative mutations mutation spectrum, perform genotype-phenotype correlation screen family members.Thirty who fulfilled criteria were...

Background: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates unknown. Methods: This study included 88 patients (age 50 ± 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) paroxysmal fibrillation (AF). mean voltage total activation time individual atria were obtained by using NavX mapping system, compared between with without previous history. dose effect was evaluated intensity‐duration, defined...