A5010092352- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Metabolism, Diabetes, and Cancer
- Cardiac tumors and thrombi
- COVID-19 Clinical Research Studies
- Coronary Interventions and Diagnostics
- Signaling Pathways in Disease
- Cardiac Structural Anomalies and Repair
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
Tomishiro Central Hospital
2013-2025
Taipei Veterans General Hospital
2003-2021
University of the Ryukyus University Hospital
2008-2020
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
National Yang Ming Chiao Tung University
2003-2017
Fukushima Medical University
2017
University of the Ryukyus
1995-2011
Taipei Medical University Hospital
2009
Chung Shan Medical University
2009
This study investigated the electrophysiologic characteristics, atrial activation pattern, and effects of radiofrequency (RF) catheter ablation guided by noncontact mapping system in patients with focal tachycardia (AT).In 13 14 ATs, was used to map guide AT. AT origins were crista terminalis (n=8), right (RA) free wall (n=3), Koch triangle (n=1), anterior portion RA-inferior vena cava junction superior tricuspid annulus (n=1); breakout sites (n=5), RA middle cavotricuspid isthmus (n=2),...
The efficacy of ablation complex fractionated atrial electrograms (CFEs) in the single procedure for nonparoxysmal fibrillation (AF) patients is not well demonstrated. aim this study was to compare strategies pulmonary vein isolation (PVI) plus linear with and without additional ofCFEs these patients.Consecutive 60 (49 +/- 11 years old, 50 male, 10 female) AF underwent catheter guided by a NavX mapping system. A stepwise approach included circumferential PVI left (LA) followed either...
COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission pathogenesis. Cardiac mitochondria produce energy for key heart functions. We hypothesized that S1 would directly impair the functions cardiomyocyte mitochondria, thus causing dysfunction.
Catheter ablation of the right atrial (RA) substrate has had variable efficacy in curing paroxysmal fibrillation (PAF), suggesting that RA can play an important role treatment (AF) some patients. The aim this study was to investigate electrophysiological characteristics and strategy its results a specific group patients with RA-AF.The population consisted 13 (8 men; age, 64+/-15 years) drug-refractory (2+/-1 drugs), frequent episodes PAF. Provocation maneuvers did not reveal any ectopic...
Objectives and Background: The success rate of achieving electrical isolation by circumferential pulmonary vein ablation (CPVA) varies from 32% to 88%. We carried out at the carina evaluate elimination rates potentials (PVPs) after one round CPVA had failed eliminate all PVPs in patients with atrial fibrillation (AF). Methods: Ninety‐seven (75 males; mean age: 50 ± 12 years; 15 persistent AF 82 paroxysmal AF) who underwent catheter were analyzed. All PVP as endpoint. electrophysiology...
There is a paucity of data regarding the mechanism maintaining atrial fibrillation (AF) after pulmonary vein isolation (PVI) in patients with AF. The aim this study was to examine impact circumferential PVI on left (LA) substrate characteristics.Seventy-two AF (age, 53+/-11 years) underwent mapping and catheter ablation using an NavX system. biatrial characteristics such as complex fractionated electrograms (CFEs; based intervals) frequency analysis (based dominant frequencies) were mapped...
Pulmonary hypertension is a disabling and life-threatening cardiovascular disease. Early detection of elevated pulmonary artery pressure (ePAP) needed for prompt diagnosis treatment to avoid detrimental consequences hypertension.This study sought develop an artificial intelligence (AI)-enabled electrocardiogram (ECG) model identify patients with ePAP related prognostic implications.From hospital-based ECG database, the authors extracted first pairs transthoracic echocardiography taken within...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel target for reducing low-density lipoprotein cholesterol. PCSK9 activates the atherosclerosis process through pro-inflammation signaling. Furthermore, serum level of is positively correlated with mortality in patients heart failure (HF). Cardiac fibrosis plays crucial role pathophysiology HF. In this study, we intended to examine whether can increase fibroblast activities and explore what its underlying mechanisms...
Background: The left atrial (LA) size is an important predictor of fibrillation (AF) procedural termination and the long‐term outcome. We sought to evaluate outcome in regard LA termination. Methods: Eighty‐seven consecutive chronic AF patients (72 males, 53 ± 10 years) underwent 3D mapping (NavX) ablation. A stepwise approach including circumferential pulmonary vein (PV) isolation, linear ablation, continuous complex‐fractionated electrogram (CFE) ablation (targeting fractionation intervals...
Right atrial substrate of supraventricular tachyarrhythmias.Voltage mapping has been used to detect diseased myocardium. However, accurate determination the local voltage at same site, and simultaneous recordings from multiple sites were limited. The purpose this study was investigate right (RA) properties in patients with tachyarrhythmias (SVT).Forty (aged 55+/-20 years) undergoing noncontact ablation SVT constituted population. There eight atrioventricular node reentrant tachycardia...
Atrial tachycardia (AT), including focal and reentrant AT, can occur after circumferential pulmonary vein isolation (CPVI). The aim of this study was to investigate the electrophysiological characteristics induced AT its clinical outcome.In our series 160 patients with paroxysmal atrial fibrillation (AF), 45 ATs were by high-current burst pacing CPVI in 26 patients. All mapped using a three-dimensional (3D) mapping system. Noninducibility endpoint ablation AT. Gap-related considered if...
The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. purposes this study were to compare electrophysiological characteristics PV fast slow cardiomyocytes.Whole-cell patch clamp was used investigate action potentials, transient outward currents (I(to)), sustained potassium (I(Ksus)), rapid delayed rectifier (I(Kr)), inward current (I(K1)), (I(f)), in isolated rabbit single (> or =2.5 Hz) (<2.5...
Myocardial infarction increases the risk of heart failure (HF) and atrial fibrillation. Renal denervation (RDN) might suppress development remodeling. This study aimed to elucidate molecular mechanism RDN in suppression fibrillation a HF model after myocardial infarction.HF rabbits were created 4 weeks coronary ligation. Rabbits classified into 3 groups: normal control (n=10), HF-RDN (n=6). Surgical chemical approached through midabdominal incisions HF-RDN. Left anterior descending artery...
Galectin-3 (Gal-3) is a biomarker of atrial fibrillation (AF) that mediates inflammation. CD98 the membrane surface receptor for Gal-3. Nevertheless, role Gal-3/CD98 axis in arrhythmogenesis unclear. In this study, we investigated effects signalling on pathogenesis.Whole cell patch clamp and western blotting were used to analyse calcium/potassium homeostasis calcium-related Gal-3-administrated HL-1 cardiomyocytes with/without neutralized antibodies. Telemetry electrocardiographic recording,...
Background: Concealed left ventricular hypertrophy (LVH) is a prevalent condition that correlated with substantial risk of cardiovascular events and mortality, especially in young to middle-aged adults. Early identification LVH warranted. In this work, we aimed develop an artificial intelligence (AI)–enabled model for early detection stratification using 12-lead ECGs. Methods: By deep learning techniques on the ECG recordings from 28 745 patients (20–60 years old), AI was developed detect...