A5076340670- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Immunodeficiency and Autoimmune Disorders
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Complement system in diseases
- Cytokine Signaling Pathways and Interactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
- Blood disorders and treatments
- Lung Cancer Treatments and Mutations
- Blood groups and transfusion
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Genomics and Rare Diseases
- Transplantation: Methods and Outcomes
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
University of Miami
2025
National Heart Lung and Blood Institute
2022-2024
National Institutes of Health
2021-2024
Cleveland Clinic
2019-2022
Jeanes Hospital
2017-2018
Temple University Hospital
2018
Abington Memorial Hospital
2017
Aga Khan University
2010
Hartford Financial Services (United States)
1972
Immune aplastic anemia (iAA) frequently results in transfusion dependence for platelets and packed red blood cells (PRBC), increasing the risk complications. The most common immune mediated cause platelet refractoriness is due to alloimmunization with human leukocyte antigen (HLA) antibody (Ab) non-self class I antigens (Ag). clinical impact of HLA has not been well studied patients iAA. We investigated relevance our large iAA patient cohort from 5 prospective trials, its correlation disease...
Heparin resistance can be defined as high doses of unfractionated heparin (UFH), greater than 35,000 IU/day, required to raise the activated partial thromboplastin time (aPTT) and coagulation (ACT) within therapeutically desired ranges or impossibility doing so. The most common pathology responsible is deficiency anti-thrombin III (ATIII) deficiency. Other clinically relevant conditions that present with are congenital deficiencies; use during extracorporeal circulation, asparaginase therapy...
Abstract Proper diagnostic distinction of bone marrow failure syndromes can often be challenging. In particular, for older patients with idiopathic aplastic anemia (AA), differential diagnosis includes myelodysplastic syndrome (MDS), which atypically present in a hypocellular form. addition to blasts and overt dysplasia, the presence chromosomal abnormalities spectrum somatic mutations may revealing. Both clonal cytogenetic aberrations most typically correspond myelodysplasia, but have also...
Summary Uncertainty remains regarding the safety and tolerability of immunosuppressive therapy (IST) with anti‐thymocyte globulin (ATG) cyclosporine (CSA) in older patients. We retrospectively analysed two prospective clinical trials IST treatment‐naïve severe aplastic anaemia (SAA) to assess compared younger Patients ≥18 years age who had received ATG CSA +/− eltrombopag (EPAG) were included. Pre‐treatment baseline characteristics co‐morbidities assessed as predictors therapy‐related...
The nucleoside analogue decitabine can deplete the epigenetic regulator DNA methyltransferase 1 (DNMT1), an effect that occurs, and is saturated at, low concentrations/doses. A reason to pursue this molecular-targeted instead of damage/cytotoxicity produced with high concentrations/doses, non-cytotoxic DNMT1-depletion cytoreduce even p53-null myeloid malignancies while sparing normal haematopoiesis. We thus identified minimum doses (0·1-0·2 mg/kg) DNMT1 without off-target anti-metabolite...
Abstract Immune severe aplastic anemia (SAA) is characterized by pancytopenia and immune‐mediated bone marrow destruction. SAA may be treated with hematopoietic stem cell transplantation (HSCT) or immunosuppressive therapy (IST). However, 30% of patients IST relapse. We previously reported a clinical trial alemtuzumab in which more than half 25 relapsed (56%) responded hematologically. Here, we present long‐term results total 42 patients. Participants who had completed antithymocyte globulin...
This study was designed to present our early experience with intravitreal bevacizumab combined laser treatment for retinopathy of prematurity (ROP) at a single institution over 13-month-period.A retrospective case series eight children ROP who received between June 2007 and July 2008 were reported. A chart review conducted evaluate if stability the lesion had been achieved. Main information collected included data on demographics, gestational age, birth weight, length stay in neonatal...
Summary T‐cell large granular lymphocytic leukaemia (T‐LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and often associated with autoimmune diseases. Among 246 T‐LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, studied clinical characterization these compared them to de novo T‐LGLL. This experience represented clear...
Natural killer (NK) cells are regulated by immunoglobulin-like receptor (KIR) interactions with human leukocyte antigen class I ligands. Various models of NK cell alloreactivity have been associated outcomes after allogeneic hematopoietic transplant (alloHCT), but results varied widely. We hypothesized that somatic mutations in acute myeloid leukemia (AML) the context KIR profiles may further refine their association outcomes. In this single-center, retrospective, observational study, 81 AML...