A5017032740- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Central Venous Catheters and Hemodialysis
- Diagnosis and Treatment of Venous Diseases
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Cardiac tumors and thrombi
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 and healthcare impacts
- Blood Coagulation and Thrombosis Mechanisms
- Infective Endocarditis Diagnosis and Management
- Cancer Treatment and Pharmacology
- Peripheral Artery Disease Management
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Intramuscular injections and effects
- Case Reports on Hematomas
- Blood Pressure and Hypertension Studies
- Actinomycetales infections and treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vascular Procedures and Complications
Mayo Clinic
2018-2025
Mayo Clinic in Arizona
2017-2025
Mayo Clinic in Florida
2018-2025
WinnMed
2020-2024
University of Toronto
2023
University of Ottawa
2023
Thornhill Medical (Canada)
2023
Center for Vascular Biology Research
2021
University of Colorado Anschutz Medical Campus
2021
University of North Carolina at Chapel Hill
2015-2020
Background Hereditary and acquired thrombophilia are risk factors for venous thromboembolism (VTE). Whether testing helps guide management decisions is controversial. Objective These evidence-based guidelines from the American Society of Hematology (ASH) intend to support decision making about testing. Methods ASH formed a multidisciplinary guideline panel covering clinical methodological expertise minimizing bias conflicts interest. The McMaster University GRADE Centre provided logistical...
ObjectiveTo evaluate differences in thromboinflammatory biomarkers between patients with severe coronavirus disease 2019 (COVID-19) infection/death and mild infection.Patients MethodsMEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, EBSCO, Web Science, CINAHL databases were searched for studies comparing COVID-19 among or death (severe/nonsurvivors) those nonsevere survivors (nonsevere/survivors) from January 1, 2020, through July 11, 2020. Inclusion criteria (1) hospitalized...
Patients with peripheral artery disease are at increased risk for major adverse cardiac events, limb and all-cause death. Developing tools capable of identifying those patients greatest events is the first step outcome prevention. This study aimed to determine whether computer-assisted analysis a resting Doppler waveform using deep neural networks can accurately identify events.
To provide direct comparison between apixaban and rivaroxaban in patients with acute cancer-associated venous thromboembolism (Ca-VTE), consecutive treated apixaban, rivaroxaban, or enoxaparin at Mayo Thrombophilia Clinic (March 1, 2013 to January 31, 2018)) were followed prospectively. The primary effectiveness outcome was (VTE) recurrence, the secondary mortality. safety major bleeding, clinically relevant non-major bleeding (CRNMB), third a composite of CRNMB. There 750 for Ca-VTE (n =...
Patterns of clinical utilization and comparative effectiveness anticoagulants for cancer-associated thrombosis (CAT) remain largely unexplored.To assess patterns factors associated with anticoagulant use to evaluate the contemporary in patients active cancer a setting.This retrospective cohort study obtained deidentified OptumLabs electronic health record claims data from January 1, 2012, September 30, 2019. Adult (≥18 years age) primary diagnosis (except skin cancer) during at least 1...
Abstract Premortem clinical presentation of cancer‐associated non‐bacterial thrombotic endocarditis (Ca‐NBTE), therapy, and the clinal course is limited to case reports small series. An electronic search Mayo Clinic records (03/31/2002–06/30/2022) with a subsequent manual review was performed identify adult patients echocardiographically detected NBTE active malignancy, excluding those infectious or lupus anticoagulant/antiphospholipid antibodies. In this retrospective cohort study, we...
Abstract Aims Echocardiographic assessment of cancer-associated non-bacterial thrombotic endocarditis (Ca-NBTE) is limited to case reports and small clinical series. The study aimed identify heart valve abnormalities its relation embolic complications cancer types. Methods results Manual review echocardiographic images medical records Mayo Clinic patients (31 March 2002–30 June 2022) was performed. Ca-NBTE in 111 (mean age 63.2 ± 9.7 years, 66.7% female) predominantly affected mitral valves...
Background: The calf muscle pump is an understudied contributor to venous return from the lower extremity. This study aimed determine if function (CPF) independently associated with severity of chronic disease classified by CEAP (Clinical-Etiology-Anatomy-Pathophysiology). Methods: Mayo Clinic Vascular Laboratory database was analyzed January 2015 through September 2023. Ambulatory adults who underwent air plethysmography were included. Venous assessed incompetence, and CPF measured as...
The safety and efficacy of anticoagulation for venous thromboembolism (VTE) at times severe thrombocytopenia is unclear. In this retrospective study, we evaluated patients with hematologic malignancy either (1) acute or chronic VTE on before platelet count dropped below 50 × 109/L (2) occurring while platelets were <50 109/L. 78 eligible patients, the primary outcomes time to recurrent clinically significant bleeding within 100 d compared by management strategy. Bleeding occurred in 27%...
Guidelines for diagnosing pulmonary embolism (PE) start with a risk assessment using pretest probability (PTP) tool, followed by D-dimer testing or computed tomography angiography (CTPA) depending on risk. The project aimed to develop an electronic clinical quality measure (eCQM) encourage broader use of validated PTP scoring tool in emergency departments (EDs) more accurately diagnose PE and reduce unnecessary CTPAs. To identify value set CTPA abnormal tests standard classification systems...
Warfarin is a commonly prescribed anticoagulant with narrow therapeutic window, requiring frequent and specialized monitoring. This work aims to develop standardized optimal warfarin dose decision support using machine learning model based on time series anticoagulation data patient demographic characteristics. We propose an offline reinforcement (RL) Batch-Constrained Q-Learning algorithm (BCQ) in the discrete action setting predict cumulative for days until next INR (International...
Abstract Background Cancer‐associated venous thromboembolism (VTE) carries a high rate of recurrence and death. Guidelines recommend continued anticoagulation therapy as long active cancer persists. Apixaban 2.5 mg twice daily is the FDA‐approved dose for secondary prevention regardless VTE causation. Whether this apixaban appropriate in patients not clear. The rationale design investigator initiated phase III, multicenter, randomized, double‐blind, trial assessing vs 5 12 months (n = 370)...