A5049581428- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- Moyamoya disease diagnosis and treatment
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Meat and Animal Product Quality
- S100 Proteins and Annexins
- Parkinson's Disease Mechanisms and Treatments
- Clusterin in disease pathology
- Biochemical effects in animals
- Barrier Structure and Function Studies
- Curcumin's Biomedical Applications
- Mitochondrial Function and Pathology
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Dementia and Cognitive Impairment Research
- Migraine and Headache Studies
- Vitamin D Research Studies
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Animal Behavior and Welfare Studies
- Bee Products Chemical Analysis
Newcastle University
2010-2020
Newcastle Hospitals - Campus for Ageing and Vitality
2010-2019
University of Huddersfield
2017
University of Nottingham
2013
Silsoe Research Institute
2006
White matter hyperintensities as seen on brain T 2 -weighted magnetic resonance imaging are associated with varying degrees of cognitive dysfunction in stroke, cerebral small vessel disease and dementia. The pathophysiological mechanisms within the white accounting for remain unclear. With hypothesis that gliovascular interactions impaired subjects high burdens hyperintensities, we performed clinicopathological studies post-stroke survivors, who had exhibited greater frontal volumes...
Previous studies suggest white matter (WM) integrity is vulnerable to chronic hypoperfusion during brain ageing. We assessed ~ 0.7 million capillary profiles in the frontal lobe WM across several dementias comprising Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease dementia, vascular mixed dementias, post-stroke as well no and similar age ageing young controls without significant pathology. Standard histopathological methods were used determine microvascular pathology...
Cerebral autosomal dominant arteriopathy with subcortical in-farcts and leukoencephalopathy (CADASIL), the most common form of familial brain arteriopathy, is associated deposition granular osmiophilic material (GOM). We used immunohistochemistry immunogold electron microscopy (EM) to examine distribution GOM NOTCH3 ectodomain (N3ECD) protein in microvasculature gray matter white patients CADASIL, non-CADASIL hereditary small-vessel disease sporadic age-related degenerative disease,...
Fat infiltration within muscle is one of a number features vitamin D deficiency, which leads to decline in functionality. The origin this fat unclear, but possibility that it forms from myogenic precursor cells present the muscle, transdifferentiate into mature adipocytes. current study examined effect active form 3 , 1,25-dihydroxyvitamin (1,25(OH) 2 ), on capacity C2C12 cell line differentiate towards and adipogenic lineages. Cells were cultured or differentiation media containing...
This study was designed to explore the beneficial effects of environmental enrichment (EE) on white matter glial changes in a mouse model chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS). A total 74 wild-type male C57BL/6J mice underwent BCAS or sham surgery. One week after surgery, were randomly assigned into three different groups having varied amounts EE—standard housing with no EE conditions (std), limited exposure 3 h day (3 h) and full-time...
We quantified vascular changes in the frontal lobe and basal ganglia of four inherited small vessel diseases (SVDs) including cerebral autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL), pontine microangiopathy (PADMAL), hereditary multi-infarct dementia Swedish type (Swedish hMID), endotheliopathy retinopathy, nephropathy, stroke (HERNS). Vascular pathology was most severe CADASIL, varied marginally greater severity compared to lobe. The overall...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by strategic white matter (WM) hyperintensities on MRI. Pathological features include WM degeneration, arteriolosclerosis, lacunar infarcts, the deposition of granular osmiophilic material. Based hypothesis that gliovascular unit compromised, we assessed nature astrocyte damage in deep CADASIL subjects.We evaluated post-mortem brains from CADASIL, cerebral small vessel...
We performed a clinicopathological study to assess the burden of small vessel disease (SVD) type pathological changes in elderly demented subjects, who had clinical evidence autonomic dysfunction, either carotid sinus hypersensitivity or orthostatic hypotension both exhibited unexpected repeated falls. Clinical and neuropathological diagnoses 112 subjects comprised dementia with Lewy bodies (DLB), Parkinson's (PDD), Alzheimer's (AD), Mixed (mostly AD-DLB) vascular (VaD). Of these, 12 DLB no...
Magnetic resonance imaging indicates diffuse white matter (WM) changes are associated with cognitive impairment in cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy (CADASIL). We examined whether the distribution of axonal abnormalities is related to microvascular pathology underlying WM.We used post-mortem brains from CADASIL subjects similar age cognitively normal controls examine WM changes, pathology, glial reaction up 16 different regions extending...
Aims Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL ) is identified by aggregates of NOTCH3 extracellular domain N3ECD along capillaries the deposition granular osmiophilic material GOM ). We assessed pattern distribution pericytes in relation to deposits cerebral microvessels subjects. Methods post mortem brains from n = 50) subjects , small vessel disease, similar‐age cognitively normal older controls. Immunohistochemical...
White matter (WM) disintegration is common in the older population and associated with vascular cognitive impairment (VCI). This study explored effects of environmental enrichment (EE) on pathological sequelae a mouse model chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis (BCAS). Male C57BL/6 J mice underwent BCAS or sham surgery. One-week after surgery, were exposed to three different degrees EE; either standard housing conditions (std), limited 3 h exposure EE...
We previously reported that, in the brains of older patients with vascular dementia (VaD), there is a distinctive accumulation detergent-extractable soluble amyloid-β, predominance Aβ42 species. It unclear, however, if tau proteins also accumulate VaD subjects. Using antibody-specific immunoassays, we assessed concentrations total (t-tau) and phosphorylated protein, measured at 3 sites (i.e. Thr181, Ser202/Thr205, Ser262), as well synaptophysin temporal frontal cortices 18 VaD, 16 Alzheimer...
Aim Brain clusterin is known to be associated with the amyloid‐β deposits in A lzheimer's disease ( AD ). We assessed distribution of immunoreactivity cerebrovascular disorders, particularly focusing on white matter changes small vessel diseases. Methods Post‐mortem brain tissues from frontal or temporal lobes a total 70 subjects various disorders including cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy CADASIL ), amyloid angiopathy CAA ) were examined...
gradient bottom PMS 1815C C13 M96 Y81 K54 on dark backgrounds light standard no gradients watermark stacked logo (for sharing only) white WHITE C0 M0 Y0 K0 black BLACK C100 M100 Y100 K100This residential programme provides attendees with a unique opportunity to receive training in key aspects of experimental psychopharmacology from leading researchers the field.The course will cover following areas, using combination plenary lectures, taught and practical sections, round-table debate team project.