A5007352854- Microbial Community Ecology and Physiology
- Schizophrenia research and treatment
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Bipolar Disorder and Treatment
- Environmental DNA in Biodiversity Studies
- Protist diversity and phylogeny
- Pharmaceutical studies and practices
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 detection and testing
- Bacterial Genetics and Biotechnology
- Genetics, Bioinformatics, and Biomedical Research
- Methane Hydrates and Related Phenomena
- Advanced biosensing and bioanalysis techniques
- Sleep and Wakefulness Research
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral gastroenteritis research and epidemiology
- Psychosomatic Disorders and Their Treatments
- Electroconvulsive Therapy Studies
- Attention Deficit Hyperactivity Disorder
- Monoclonal and Polyclonal Antibodies Research
McGill Genome Centre
2022-2024
McGill University
2022-2024
Environment and Climate Change Canada
2022-2024
Concordia University
2019-2023
Université de Montréal
2023
Concord University
2022
Bureau de Coopération Interuniversitaire
2022
Public Health Agency of Canada
2022
Eli Lilly (Germany)
2009-2021
Laboratoire Interuniversitaire de Biologie de la Motricité
2021
Many patients with schizophrenia and bipolar disorder have impaired insight low medication adherence. The aim of this post hoc analysis was to explore the relationship between We included 903 or who participated in an observational study conducted Europe on outcomes treated two oral formulations olanzapine over a 1-year period. Evaluations Clinical Global Impression (CGI), Assessment Functioning (GAF), (Scale Assess Unawareness Mental Disorder, SUMD) adherence (Medication Adherence Rating...
Accurately identifying the species present in an ecosystem is vital to lake managers and successful bioassessment programs. This particularly important when monitoring cyanobacteria, as numerous taxa produce toxins can have major negative impacts on aquatic ecosystems. Increasingly, DNA-based techniques such metabarcoding are being used for measuring biodiversity, they could accelerate processing time, decrease costs reduce some of biases associated with traditional light microscopy. Despite...
Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood. This study was designed to estimate the prevalence of ADHD in adult psychiatric outpatients several European countries.ADHD diagnosis made using Diagnostic Interview for Adults, version 2.0 (DIVA), according criteria and Statistical Manual Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) 5th Edition (DSM-5).Of 5662 patients present/approached, 2284 (40.3 %) consented, whom 1986 (87.0 completed study. Based...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a generalist virus, infecting and evolving in numerous mammals, including captive companion animals, free-ranging wildlife, humans. Transmission among non-human species poses risk for the establishment of SARS-CoV-2 reservoirs, makes eradication difficult, provides virus with opportunities new evolutionary trajectories, selection adaptive mutations emergence variant lineages. Here, we use publicly available viral genome...
Wastewater-based surveillance (WBS) is an important epidemiological and public health tool for tracking pathogens across the scale of a building, neighbourhood, city, or region. WBS gained widespread adoption globally during SARS-CoV-2 pandemic estimating community infection levels by qPCR. Sequencing pathogen genes genomes from wastewater adds information about genetic diversity, which can be used to identify viral lineages (including variants concern) that are circulating in local...
Our understanding of microbial biogeography has been governed by the dictum “Everything is everywhere, but environment selects.” In other words, distribution microbes thought to occur in a regime extensive dispersal and strong selection, generating local adaptation. However, direct tests these assumptions are rare. Here, we investigate extent adaptation space time collection soil-derived isolates, most belonging genus Pseudomonas, across growing season from deciduous forest western Quebec,...
The aim of the present study is to analyze how well physiological measures sleepiness derived from pupillography and Multiple Sleep Latency Test correlate with a subjective measure, Stanford Sleepiness Scale (SSS) score. results are based on data 12 healthy participants, who underwent these tests every 2 hr 7:00 a.m. until 11:00 p.m. latencies were correlated four different variables SSS indicate that physiologically correspond very well. This reflected by similar patterns time‐of‐day...
Olanzapine long-acting injection (OLAI) is a sustained-release depot antipsychotic for the treatment of schizophrenia in adults. Our objective was to explain pharmacokinetics OLAI provide clinical insight. Simulation models and data from trials are presented. concentrations were observed immediately upon injection. Half-life ∼30 days, controlled by slow rate intramuscular absorption rather than 30-h elimination rate-based half-life oral olanzapine. As each builds on drug still being released...
This observational study explored the prevalence of metabolic syndrome (MetS) in adult in- and outpatients with untreated or treated schizophrenia at baseline, month-3 after initiation switch antipsychotic treatment. MetS-prevalence (AHA/NHLB-definition) was assessed Clopper-Pearson 95% confidence intervals (CIs) were calculated. Factors associated MetS through univariate multivariate logistic regressions (both visits). 44.3% (CI 39.8;48.9) baseline 49.6% 45.0;54.2) month-3. Previously...
Protists play key roles in aquatic food webs as primary producers, predators, nutrient recyclers, and symbionts. However, a comprehensive view of protist diversity freshwaters has been challenged by the immense environmental heterogeneity among lakes worldwide. We assessed surface waters 366 freshwater across north temperate to subarctic range covering nearly 8.4 million km2 Canada. Sampled represented broad gradients size, trophic state, watershed land use. Hypereutrophic contained least...
To assess the burden of illness and health care resource utilization adult nonpsychotic psychiatric outpatients with attention-deficit/hyperactivity disorder (ADHD) in Europe.This was a multicountry, cross-sectional, observational study where unselected routine patients from clinical outpatient settings were screened assessed for ADHD. Patients evaluated using Clinical Global Impressions Severity (CGI-S) scale, Sheehan Disability Scale (SDS), EuroQol-5 Dimensions questionnaire. Data on...
Migraine is a neurological disease with considerable economic and societal burden that negatively impacts quality of life productivity. Triptans are potent serotonin receptor agonists widely used to treat migraine attacks. Little known about German patients diagnosed triptan contraindications or those who discontinue triptans.
ABSTRACT Wastewater-based epidemiology has emerged as a promising tool to monitor pathogens in population, particularly when clinical diagnostic capacities become overwhelmed. During the ongoing COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), several jurisdictions have tracked viral concentrations wastewater inform public health authorities. While some studies also sequenced SARS-CoV-2 genomes from wastewater, there been relatively few direct...
Our decreasing ability to fight bacterial infections is a major health concern. It arising due the evolution of antimicrobial resistance (AMR) in response mis- and overuse antibiotics both human veterinary medicine. Lakes integrate watershed processes thus may act as receptors reservoirs antibiotic genes (ARGs) introduced into by activities. The resistome - diversity ARGs under varying anthropogenic pressures has been previously studied either focused on few select or lakes. Here, we link...
Disrupted sleep is prevalent in both mood and thyroid disorders. Given the emerging use of hormones treatment disorders, we investigated effects supraphysiological doses levothyroxine (L-T4) on sleep. In an open-label design, 13 healthy subjects received up to 500 μ g/day for eight-week period. A baseline night was polysomnographically recorded (PSG) followed by PSG under maximum tolerated dose L-T4. All developed hyperthyroxinemia. The heart rate respiration increased significantly with...
Purpose: Medication nonadherence is common in the treatment of patients with severe mental illness and a frequent cause relapse. Different formulations have been developed an effort to improve medication adherence. The aim this study was explore whether there are differential clinical outcomes between two different olanzapine (orodispersible tablets [ODTs] vs standard oral [SOT]) for nonadherent schizophrenia or bipolar disorder. Methods: Data analysis were from observational conducted...
Lakes are sentinels of environmental changes within their watersheds including those induced by a changing climate and anthropogenic activities. In particular, contamination originating from point or non-point sources (NPS) might be reflected in the bacterial composition lake water. We assessed abundance potentially pathogenic bacteria (PPB) sampled 413 lakes 8 southern Canadian ecozones that represent wide diversity watershed land use. The study objectives were (1) to explore PPB; (2) build...
The COVID-19 pandemic led to a large global effort sequence SARS-CoV-2 genomes from patient samples track viral evolution and inform the public health response. Millions of genome sequences have been deposited in repositories. Canadian Genomics Network (CanCOGeN – VirusSeq), consortium tasked with coordinating expanded sequencing across Canada early pandemic, created VirusSeq Data Portal, associated data pipelines procedures, support these efforts. goal was allow open access genomic...
Abstract Molecular genetic approaches applied to environmental DNA have great potential for biodiversity research and ecosystem monitoring. A metagenome is produced via shotgun sequencing of collected directly from the environment represents a sample information all organisms captured in an sample. Metagenomes been primarily used study bacteria archaea, but promising reports focusing on metazoan diversity are emerging. However, methodological uncertainties remain, studies required validate...