A5101435920- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Biochemical and Structural Characterization
- Sphingolipid Metabolism and Signaling
- Neurofibromatosis and Schwannoma Cases
- MicroRNA in disease regulation
- Carbohydrate Chemistry and Synthesis
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- Cancer Mechanisms and Therapy
- Enzyme Production and Characterization
- Traumatic Brain Injury and Neurovascular Disturbances
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
- Complement system in diseases
- Brain Metastases and Treatment
- Endometrial and Cervical Cancer Treatments
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Meningioma and schwannoma management
- Tuberous Sclerosis Complex Research
- Blood properties and coagulation
University of South Alabama
2018-2021
University of Alabama at Birmingham
2021
University of Vermont
2021
USA Mitchell Cancer Institute
2018-2019
Medical College of Wisconsin
2017-2018
Milwaukee VA Medical Center
2017
Institut National de la Recherche Scientifique
2009
University of Illinois Chicago
2007-2008
University of California, Davis
2005
Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received great deal of interest in recent years as potential target for the development new therapeutics against melanoma and glioblastoma tumors. Despite strong obtaining structural information, only structures apo-AC enzyme its zymogen activated conformations are available. In this work, crystal structure AC complex with covalent carmofur inhibitor presented. Carmofur an antineoplastic drug containing electrophilic...
Glioblastoma (GBM) remains one of the most aggressive cancers, partially due to its ability migrate into surrounding brain. The sphingolipid balance, or balance between ceramides and sphingosine-1-phosphate, contributes GBM cells invade. Of ceramidases which hydrolyze ceramides, acid ceramidase (ASAH1) is highly expressed in samples compared non-tumor ASAH1 expression also correlates with genes associated migration focal adhesion. To understand role migration, we utilized shRNA knockdown...
Human α2M (α2-macroglobulin) and the complement components C3 C4 are thiol ester-containing proteins that evolved from same ancestral gene. The recent structure determination of human has allowed a detailed prediction location domains within to be made. We describe here expression characterization three predicted involved in stabilization ester native its activation upon bait region proteolysis. newly expressed MG2 (macroglobulin domain 2), TED (thiol domain) CUB (complement protein...
Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology.With the SEER-18 registry database, information from all patients diagnosed with intracranial HB 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent receipt radiation, tumor size, location, and follow-up data. Age-adjusted incidence rates overall survival (OS). Cox proportional hazards model was employed for both univariate multivariate...
ABSTRACT Quantification of biomechanical tolerance is necessary for injury prediction and protection vehicular occupants. This study experimentally quantified lumbar spine axial during accelerative environments simulating a variety military civilian scenarios. Intact human spines (T12‐L5) were dynamically loaded using custom‐built drop tower. Twenty‐three specimens tested at sub‐failure failure levels consisting peak forces between 2.6 7.9 kN corresponding accelerations 7 57 g. Military...
The absence of major progress in the treatment glioblastoma (GBM) is partly attributable to our poor understanding both GBM tumor biology and acquirement resistance recurrent GBMs. Recurrent GBMs are characterized by their radiation. In this study, we used an established stable U87 radioresistant model total RNA sequencing shed light on global mRNA expression changes following irradiation. We identified many genes, expressions which were altered model, that have never before been reported be...
alpha-Macroglobulins (alphaMs) are large glycoproteins that have been identified in a wide range of vertebrate and invertebrate species mostly thiol ester containing proteinase inhibitors. A recent analysis bacterial genomes ( Budd, A., Blandin, S., Levashina, E. Gibson, T. J. (2004) Genome Biol. 5, R38 ) many alpha-macroglobulin-like sequences appear to acquired by Gram-negative bacteria from their metazoan hosts. We report the first expression characterization such alpha-macroglobulin,...
Abstract Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides sphingosine, which phosphorylated by sphingosine kinases generate S1P. The S1P allows shifting the equilibrium away from ceramides, favor cell death. One tumor type that exhibits a shift sphingolipid balance towards glioblastoma (GBM), highly aggressive brain tumor. GBMs almost always recur...
Pediatric glioblastoma (GBM) is a relatively rare brain tumor in children that has dismal prognosis. Surgery followed by radiotherapy the main treatment protocol used for older patients. The benefit of adjuvant chemotherapy still limited due to poor understanding underlying molecular and genetic changes occur with irradiation tumor. In this study, we performed total RNA sequencing on an established stable radioresistant pediatric GBM cell line identify mRNA expression following radiation....
Glioblastoma (GB) and its variants portend a poor prognosis. The predominant cause of death (COD) is related to the cancer diagnosis, but significant subset other causes. As GB systemic disease requiring treatment, focus regarding all COD provides comprehensive illustration disease.The SEER-18 was queried for patients with cranial variants. Age, gender, race, marital status, tumor characteristics, treatment details, follow-up data were acquired. classified into group A (death attributed this...
For gliomas, metropolitan status has not been heavily explored in the context of short-term mortality or long-term observed survival. Larger populations are associated with proximity to academic universities/high-volume hospitals.The SEER-18 registry was queried for patients gliomas. The were further classified into two population groups based on rural-urban continuum codes: non-metropolitan. Demographics and clinical factors compared between both groups. survival, univariate multivariate...
Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after lower grade glioma. Though knowledge regarding this has gained traction in recent years, its definition continues evolve, complicating clinical management. Investigation epidemiology survival patterns may help provide needed insights.The age at GB diagnosis is significantly (46.22 vs 60.25 years) for group B. The distribution among type (glioblastoma, giant cell glioblastoma, or gliosarcoma) was...
Olfactory groove meningiomas are slow-growing tumors that manifest with headaches, changes in vision, and personality changes. The anatomic location of these makes psychiatric disturbances more common early the stage than focal neurological deficits. case study here describes a unique instance an undiagnosed giant olfactory meningioma young mother who was charged felony aggravated child abuse for death her toddler daughter. patient underwent gross tumor resection radiation therapy, which...
Abstract Dysregulated sphingolipid metabolism is associated with many cancers; allowing cells to evade apoptosis through increases in sphingosine-1-phosphate (S1P) and decreases ceramides. Ceramides can be hydrolyzed by ceramidases sphingosine, which then phosphorylated sphingosine kinases S1P. S1P allows increase migration, while shifts toward ceramides favor cell death. Glioblastoma (GBM) exhibits the balance towards S1P, contributing chemoresistance migration. Understanding of GBM still...
Chronic subdural hematoma (cSDH) is a common neurosurgical pathology associated with prior traumatic brain injury (TBI) and older age that often complicated by antiplatelet or anticoagulant therapies. cSDH results from the liquefaction of previous acute accompanies TBI. The incidence will likely increase over next 25 years, placing burden on health care costs. As such, simple, inexpensive treatment option desirable. In this short communication, we describe recent data different techniques...
Abstract For see ChemInform in Full Text.
BACKGROUND: Chemo- and radioresistance are characteristic features of post-treatment high-grade glioma (HGG). The cell populations responsible for this treatment-resistant phenotype stem cells (GSCs). These GSCs have a high requirement iron which is essential tumor viability. Intriguingly, the transferrin receptors that play crucial role in uptake by both adult pediatric astrocytomas exhibit affinity gallium maltolate (GaM), novel mimetic. Given added commonality between signatures,...