A5038959255- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Spinal Hematomas and Complications
- Cervical and Thoracic Myelopathy
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Neurological disorders and treatments
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Spinal Cord Injury Research
- Cancer, Hypoxia, and Metabolism
- Sphingolipid Metabolism and Signaling
- Scoliosis diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury Research
- Cancer Mechanisms and Therapy
- Musculoskeletal pain and rehabilitation
Loyola University Chicago
2025
Medical College of Wisconsin
2013-2020
North American Skull Base Society
2019
Children's Hospital of Wisconsin
2016-2018
Neurological Surgery
2010-2018
Indiana University – Purdue University Indianapolis
2010-2013
Riley Hospital for Children
2013
Indiana University School of Medicine
2011-2012
<h3>BACKGROUND AND PURPOSE:</h3> Patients with recurrent glioblastoma often exhibit regions of diffusion restriction following the initiation bevacizumab therapy. Studies suggest that these represent either diffusion-restricted necrosis or hypercellular tumor. This study explored postmortem brain specimens and a population analysis overall survival to determine identity implications such lesions. <h3>MATERIALS METHODS:</h3> Postmortem examinations were performed on 6 patients progressively...
Object The aim of this study was to identify the benefits intraventricular baclofen (IVB) therapy for treatment intractable spasticity or dystonia in a subset patients who had experienced multiple revisions while receiving intrathecal (ITB) therapy. Methods authors reviewed charts 22 consecutive with initially underwent ITB therapy, subsequently suffered during and ultimately received IVB all 12-year period from November 1998 October 2010. catheters were positioned lateral ventricle, aided...
Glioblastoma multiforme (GBM) is the most common primary, intracranial malignancy of central nervous system. The standard treatment protocol, which involves surgical resection, and concurrent radiation with adjuvant temozolomide (TMZ), still imparts a grim prognosis. Ultimately, all GBMs exhibit recurrence or progression, developing resistance to treatment. This study demonstrates that acquire via upregulation acid ceramidase (ASAH1) sphingosine‑1-phosphate (Sph-1P). Moreover, inhibition...
Abstract Background There is increased interest in concurrent kilovoltage (kV) imaging during megavoltage (MV) irradiation as a means of monitoring intra‐fraction motion. However, scatter introduced by the MV beam degrades kV image quality, potentially making tumor visualization more challenging. Purpose To implement novel imager readout modes on on‐board (OBI) Varian TrueBeam to reduce effect detector. Methods New strategies (vertical 3 × 2 binning, vertical region interest, pulse drop...
Much has been reported regarding the technique of performing an awake craniotomy with cortical mapping for functional cortex responsible sensorimotor activity and language. However, documentation visual during a description its technical details is rare. The authors report case patient who underwent to remove glioma situated in left medial occipital lobe. techniques that made such procedure possible are discussed.
Pediatric brain tumors are the most common solid in children and also a leading culprit of cancer-related fatalities children. remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, atypical teratoid rhabdoid express significant levels acid ceramidase, where highest radioresistant tumors, suggesting ceramidase may confer radioresistance. More importantly, showed inhibitors highly effective at targeting these with low IC50 values (4.6-50 μM). This...
Assessment of bone quality can guide spinal surgery. However, surgeons infrequently evaluate in a quantitative manner. Recent literature suggests role for computed tomography (CT) Hounsfield units (HUs) as marker quality. Limited data exist regarding its utility with respect to posterolateral lumbar fusion (PLF).From fall 2010 winter 2012, 10 patients underwent revision surgery symptomatic pseudoarthrosis (defined intractable pain associated either radiographic evidence nonunion or...
Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology.With the SEER-18 registry database, information from all patients diagnosed with intracranial HB 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent receipt radiation, tumor size, location, and follow-up data. Age-adjusted incidence rates overall survival (OS). Cox proportional hazards model was employed for both univariate multivariate...
The absence of major progress in the treatment glioblastoma (GBM) is partly attributable to our poor understanding both GBM tumor biology and acquirement resistance recurrent GBMs. Recurrent GBMs are characterized by their radiation. In this study, we used an established stable U87 radioresistant model total RNA sequencing shed light on global mRNA expression changes following irradiation. We identified many genes, expressions which were altered model, that have never before been reported be...
Lumbar endplate fractures were investigated in different experimental scenarios, however the biomechanical effect of segmental alignment was not outlined. The objectives this study to quantify effects spinal orientation on lumbar spine injuries during single-cycle compressive loads and understand injury tolerance. Twenty motion segments compressed failure. Two methods used preparation segments. Group 1 (n = 7) maintained pre-test sagittal lordosis, whereas 2 13) specimens had a...
Lumbar back pain and radiculopathy are common diagnoses. Unfortunately, conventional magnetic resonance imaging (MRI) findings clinical symptoms do not necessarily correlate in the lumbar spine. With upright imaging, disc pathologies or foraminal stenosis may become more salient, leading to improvements diagnosis.Seventeen adults (10 asymptomatic 7 symptomatic volunteers) provided their informed consent participated study. A 0.6T MRI scan was performed on each adult seated position....
Glioblastoma can mimic various pathologies, including arteriovenous malformation, hemorrhage from ischemic stroke, cerebral contusion, metastatic disease, lymphoma, and infection. The literature is limited regarding diagnostic confusion with meningioma. Herein, we present 2 patients that exhibited imaging, angiography during preoperative embolization, which was consistent meningioma, but where final surgical diagnosis revealed glioblastoma.Case 1 a 57-year-old woman presenting headache,...
Extra-axial hematoma can cause significant brain compression. Guidelines for surgical evacuation include imaging findings (midline shift and thickness/volume) in conjunction with Glasgow Coma Scale (GCS) scores and/or intracranial pressure (ICP) monitoring. Physiologically, overall density should also change In our observational study, we explored whether density, defined using computed tomography Hounsfield Units (CT HU), changes after of extra-axial hematoma.Only patients a acute epidural...
The association between glioblastoma and intracranial aneurysm is rare. Treatment guidelines do not exist, operative mortality morbidity are significantly high. To our knowledge, no prior cases have employed endovascular therapy for the treatment of these intra-tumor aneurysms followed by tumor resection.A 74-year-old male, history a left A2 aneurysm, presented after motor vehicle accident at low speeds. Imaging was concerning possible traumatic brain contusion, an aneurysmal hemorrhage...
Bow hunter's syndrome, also known as rotational vertebrobasilar insufficiency, arises from mechanical compression of the vertebral artery during neck rotation. Surgical options have been mainstay treatment choice. Postoperative imaging is typically used to assess adequate decompression. On other hand, intraoperative assessment decompression has rarely reported.A 52-year-old male began see "black spots," and experienced presyncope whenever he rotated his head toward right. The patient...