A5056346798- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Genetic Mapping and Diversity in Plants and Animals
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Animal Nutrition and Physiology
- Liver Disease Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Genomics and Chromatin Dynamics
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Renal Diseases and Glomerulopathies
- Estrogen and related hormone effects
- Cell Adhesion Molecules Research
- Viral gastroenteritis research and epidemiology
- Cervical Cancer and HPV Research
- Intracerebral and Subarachnoid Hemorrhage Research
Dalian Medical University
2025
First Affiliated Hospital of Dalian Medical University
2025
Karolinska Institutet
2002-2023
Tsinghua University
2023
Integrated Cardio Metabolic Centre
2018-2022
AstraZeneca (Sweden)
2019-2022
Karolinska University Hospital
2002-2022
Harvard Stem Cell Institute
2018
Harvard University
2018
Swedish University of Agricultural Sciences
2013-2015
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair. Loss of pericytes has been described several brain disorders, genetically induced pericyte deficiency the leads to increased macromolecular leakage across blood-brain barrier (BBB). However, molecular details endothelial response remain elusive. Objective: To map transcriptional changes resulting from lack contact at single-cell level correlate them...
Accumulation of amyloid β-peptide (Aβ) is a driver Alzheimer's disease (AD). Amyloid precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology, allowing elucidation downstream effects accumulation and their temporal appearance upon progression. Here we have investigated the sequential onset AD-like pathologies in AppNL-F AppNL-G-F mice by time-course transcriptome analysis hippocampus, region severely affected AD. Strikingly, energy metabolism emerged as one most...
Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development excess body fat-related metabolic complications. Animal studies have suggested presence distinct subtypes ASCs with different differentiation properties. In addition, are becoming biggest source mesenchymal used in therapies, which requires deep characterization. Using unbiased single cell transcriptomics we aimed to characterize ASC populations human subcutaneous white (scWAT). The transcriptomes 574 from...
Liver macrophages exacerbate oxidative stress in obesity-induced hepatic steatosis by blocking the endogenous antioxidant response.
The purpose of this research was to evaluate the clinical significance p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen (PCNA) expression in tumor progression cervical cancer.Seventeen patients (40 samples) with consecutive lesions from normal squamous epithelium, inflammation cervix intraepithelial neoplasm (CIN) invasive cancer (SCC), or CIN SCC were collected for study. Expression PCNA detected by immunohistochemistry on paraffin-embedded sections. Human papillomavirus DNA...
Cognate soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins are now known to associate the secretory vesicle with both target plasma membrane and Ca2+ channels in order mediate sequence of events leading exocytosis neurons neuroendocrine cells. Neuroendocrine cells, particularly insulin-secreting islet β-cells, t-SNARE proteins, 25-kDa synaptosomal-associated (SNAP-25), syntaxin 1A, independently inhibit L-type channel (LCa). However, when present, they...
Abstract Objective The prevalence of overweight and obesity among children has drastically increased during the last decades maternal been demonstrated as one ultimate factors. Nutrition-stimulated transgenerational regulation key metabolic genes is fundamental to developmental origins syndrome. Fetal nutrition may differently influence female male offspring. Methods Mice dam were fed either a control diet or high-fat (HFD) for 6-week prior mating continued their respective gestation...
Mapping of chromosomal regions harboring genetic polymorphisms that regulate complex traits is usually followed by a search for the causative mutations underlying observed effects. This often challenging task even after fine mapping, as millions base pairs including many genes will typically need to be investigated. Thus trace mutation(s) there great efficient bioinformatic strategies. Here, we searched and regulating growth in Virginia chicken lines - an experimental population comprising...
Mutations of signal-induced proliferation-associated gene 1 (SIPA1), a RAP1 GTPase-activating protein, were reported in patients with juvenile myelomonocytic leukemia, childhood myelodysplastic/myeloproliferative neoplasm (MDS/MPN). Sipa1 deficiency mice leads to the development age-dependent MPN. However, expression bone marrow (BM) microenvironment and its effect on pathogenesis MPN remain unclear. We here report that is expressed human mouse BM stromal cells downregulated these from or...
The response to overfeeding is sex dependent, and metabolic syndrome more likely associated obesity in men or postmenopausal women than young fertile women. We hypothesized that obesity-induced dependent due a sex-specific regulation of the fatty acid (FA) synthesis pathways liver white adipose depots. aimed identify distinctive molecular signatures between sexes using lipidomics approach characterize lipid species liver, perigonadal tissue, inguinal tissue correlate them physiopathological...
Abstract Anti-silencing function 1a (ASF1a) is a histone H3–H4 chaperone isoform involved in chromatin assembling and transcription regulation. Recently, ASF1a has been shown to be up-regulated certain human malignancies required for the expression of telomerase reverse transcriptase (TERT), factor essential immortal phenotype cancer cells; however, its role oncogenesis remains poorly defined. In present study, we determine whether unlimited proliferation cells, key hallmark. Elevated mRNA...
Inflammatory pathways are activated in most glomerular diseases but molecular mechanisms driving them kidney tissue poorly known. We identified retinoic acid receptor responder 1 (Rarres1) as a highly podocyte-enriched protein healthy kidneys. Studies podocyte-specific knockout animals indicated that Rarres1 was not needed for the normal development or maintenance of glomerulus filtration barrier and did modulate outcome disease model glomerulonephritis. Interestingly, we detected an...
Although tyrosine kinase inhibitors are effective for treating chronic myeloid leukemia (CML), they often fail to eradicate the leukemia-initiating stem cells (LSCs), causing disease persistence and relapse. Evidence indicates that LSC may be due bone marrow (BM) niche protection. However, little is known about underlying mechanisms. We here molecularly functionally characterized BM niches in CML patients at diagnosis revealed altered composition function patients. Long-term culture...
Ovarian germ cell tumors (OGCTs) and sex cord stromal (SCSTs) are rare gynecologic that derived from cells, respectively. Unlike their epithelial counterparts, molecular pathogenesis of these tumor types is still poorly understood. Here, we characterized microRNA (miRNA) expression profiles 9 OGCTs (2 malignant 7 benign) 3 SCSTs using small RNA sequencing. We observed significant miRNA variations among the three groups. To further demonstrate biological relevance our findings, selected 12...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, partly due to dense desmoplasia and a lack suitable model systems study. In present work, we developed 3D heterospecies spheroid study microenvironmental interactions between tumor cells stellate which can also be employed test therapeutic regimens. We set up monospheroids heterospheroids made from murine pancreatic (mPSCs) human PDAC (Panc1), allowed for direct isolation mRNA mixed cell population followed by an...
Abstract The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca 2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. While phospholamban is a bona-fide therapeutic target, approaches to selectively inhibit this protein remain elusive. Here, we report in vivo application of acting antibodies (intrabodies), derived from variable domain camelid heavy-chain antibodies, modulate...
Here, we describe the results from first variance heterogeneity Genome Wide Association Study (VGWAS) on yeast expression data. Using this forward genetics approach, show that genetic regulation of gene-expression in budding yeast, Saccharomyces cerevisiae, includes mechanisms can lead to between genotypes. Additionally, performed a mean effect association study (GWAS). Comparing and analyses, find level is under larger absolute number loci but higher proportion controlling were...