A5031609238- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Vitamin D Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Bone health and treatments
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Advanced Glycation End Products research
- Adrenal Hormones and Disorders
- Bone and Joint Diseases
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Bone health and osteoporosis research
- Vitamin C and Antioxidants Research
- Muscle and Compartmental Disorders
- Pancreatic function and diabetes
- Glioma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Diabetes Treatment and Management
Marmara University
2020-2024
Cedars-Sinai Medical Center
2023-2024
Istanbul Technical University
2024
Istanbul University-Cerrahpaşa
2018-2020
Istanbul University
2016-2017
Vitamin D deficiency has emerged as another potential risk factor for coronavirus disease (COVID-19) due to the immunomodulatory effects of 25 hydroxyvitamin [25 (OH)D]. receptor (VDR) gene polymorphisms such Fok I, Bsm Apa and Taq I are also associated with different courses viral infections. This study aimed evaluate association between VDR polymorphism at genotypes prognosis COVID-19 in respect vitamin deficiency.Two-hundred ninety-seven patients were enrolled. Serum (OH)D levels...
Abstract Background Angiotensin‐converting enzyme 2 and transmembrane protease serine are critical factors of virus transmission. Expression angiotensin‐converting is highest in testes, testicular function testosterone levels were affected by coronavirus disease 2019. Low related to infections, especially respiratory tract could worsen clinical conditions exacerbating cytokine storms increasing pro‐inflammatory cytokines. Objectives We aimed evaluate the acute chronic effects 2019 on gonadal...
Abstract DNA damage‐induced senescence is initially sustained by p53. Senescent cells produce a senescence‐associated secretory phenotype (SASP) that impacts the aging microenvironment, often promoting cell transformation. Employing normal non‐tumorous human colon (hNCC) derived from surgical biopsies and three‐dimensional intestinal organoids, we show local non‐pituitary growth hormone (npGH) induced in senescent SASP component acting to suppress npGH autocrine/paracrine suppression of p53...
The renin-angiotensin-aldosterone system was shown to be activated in severe COVID-19 infection. We aimed investigate the relationship between angiotensin converting enzyme (ACE) levels, ACE gene polymorphism, type 2 diabetes (T2DM), and hypertension (HT) prognosis of infection.This cross-sectional study analyzed clinical features adult patients with SARS-CoV-2 analysis level measurements were performed. grouped according polymorphism (DD, ID or II), disease severity (mild, moderate,...
Abstract Purpose The authors review the clinical outcomes of patients with primary hypophysitis (PH). Methods Patients PH who were followed up between 2007 and 2018 at our clinic evaluated. Clinical, endocrinologic, pathologic, radiologic findings treatment modalities assessed. Results Seventeen median follow-up was 24 (range, 6–84) months. Histologic confirmation available in 8 (6 lymphocytic hypophysitis, 1 lymphocytic-granulomatous xanthomatous hypophysitis). None cases diagnosed after...
Highlights•Phosphatase WIP1 is a newly described target for epithelial GH action•GH suppresses DNA damage response pathway by inducing WIP1•GH acts through Src/AMPK/HIPK2, enhancing stability•GH/WIP1 action results in unrepaired accumulationSummaryDNA repair (DDR) mediated phosphorylating effectors ATM kinase, CHK2, p53, and γH2AX. We showed earlier that DDR suppressing pATM, resulting accumulation. Here, we show acting receptor (GHR) wild-type p53-inducible phosphatase 1 (WIP1), which...
COVID-19 infection may have multiorgan effects in addition to on the lungs and immune system. Recently, studies found thyroid function abnormalities cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, this study, we aimed evaluate status autoimmunity patients. Material Method. 205 patients included. The medical history laboratory parameters at admission collected from records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4),...
To determine the efficacy and safety of stereotactic radiotherapy (RT) in patients with Cushing's disease (CD).The study included 38 [31 who received gamma knife radiosurgery (GKS) 7 cyberknife hypofractionated RT (HFRT)] CD. Hormonal remission was considered if patient had suppressed cortisol levels after low dose dexamethasone, normal 24-hour urinary free (UFC), lack or regression clinical features.Biochemical control observed 52.6% CD median time to hormonal 15 months. Tumor size obtained...
Thrombotic thrombocytopenic purpura is a potentially life-threatening condition. Although the introduction of therapeutic plasma exchange has reduced mortality rates from over 90% to 10%-20%, approximately 40% patients relapse, and outcomes may be fatal in refractory patients. There clearly need for additional approaches.To describe relapsed/refractory thrombotic treated with vincristine as an adjunct exchange.Cross-sectional study.The medical records all between October 2000 December 2016...
Maturity-onset diabetes of the young (MODY) is a rare monogenic type diabetes, and accounts for 2-5% all cases. An early age onset, family history supporting autosomaldominant inheritance, insulin resistance, absence autoimmunity are major characteristics MODY. However, genetic testing crucial diagnosis.To investigate 7 MODY-related genes clinical findings patients with preliminary diagnosis MODY.Retrospective cross-sectional study.In this study, (KCNJ11, ABCC8, INS, GCK, HNF4A, HNF1A,...
Abstract Introduction Riedel's thyroiditis (RT) is an uncommon characterized by fibrosis, macrophage, and eosinophil infiltration assumed to be the primary cause of autoimmunity in pathogenesis. Invasion surrounding tissues, particularly trachea, occurs. RT also regarded as thyroid involvement IgG4-related systemic illness. Because there no conventional medical treatment protocol for RT, this paper aims highlight problems we had diagnosing our approach throughout therapy. Clinical Case In...
Purpose: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate nationwide prevalence of vitamin status in tertiary care hospitals Turkey. Methods: Retrospectively, data levels from 33 hospitals’ clinical biochemistry laboratories Turkey between 2 January 2016 and 31 December were conducted. Results: In total 706434 serum samples adult subjects (F/M: 469028/ 237406; 66.4%/ 33.6%) included. While sufficient 20.3% (n=14222), they insufficient 21.9%...