A5085773349- Malaria Research and Control
- Drug Transport and Resistance Mechanisms
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Virus-based gene therapy research
- Pharmacological Effects and Toxicity Studies
- Toxoplasma gondii Research Studies
- Invertebrate Immune Response Mechanisms
- HIV/AIDS drug development and treatment
- Protein Structure and Dynamics
- Immune Cell Function and Interaction
- Lipid Membrane Structure and Behavior
- CAR-T cell therapy research
German Cancer Research Center
2023-2024
Universität Hamburg
2021-2023
Bernhard Nocht Institute for Tropical Medicine
2021-2023
Centre for Structural Systems Biology
2021-2023
Heidelberg University
2023
National Center for Tumor Diseases
2023
The tethering complexes HOPS/CORVET are central for vesicular fusion through the eukaryotic endolysosomal system, but functions of these in intracellular development malaria parasites still unknown. Here we show that core subunits critical proliferation parasite Plasmodium falciparum. We demonstrate required endocytosis and host cell cytosol uptake, as early functional depletion complex led to developmental arrest accumulation endosomes failed fuse digestive vacuole membrane. Late a severe...
Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred by complex array subpellicular microtubules (SPMT) associated with the inner membrane (IMC). Microtubule-associated proteins (MAPs) define MT populations and modulate interaction pellicular components. Several MAPs have been identified in Toxoplasma gondii, homologues can be found genomes
Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on membrane for the uptake nutrients from host, disposal metabolic waste, exchange metabolites between organelles, and generation maintenance transmembrane electrochemical gradients its growth replication within erythrocytes. Despite their importance
Abstract Treatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK cells show only modest direct cytotoxic activity against tumor To specifically towards developed encoding bispecific engagers (MV-BiKE) targeting CD16A on and carcinoembryonic antigen (CEA) as a model antigen. MV-BiKE are slightly attenuated compared to parental MV mediate secretion functional BiKE from infected We tested in...
During the symptomatic human blood phase, malaria parasites replicate within red cells. Parasite proliferation relies on uptake of nutrients, such as amino acids, from host cell and plasma, requiring transport across multiple membranes. Amino acids are delivered to parasite through parasite-surrounding vacuolar compartment by specialized nutrient-permeable channels erythrocyte membrane parasitophorous vacuole (PVM). However, further plasma (PPM) is currently not well characterized. In this...
The tethering complexes HOPS/CORVET are central for vesicular fusion through the eukaryotic endolysosomal system, but functions of these in intracellular development malaria parasites unknown. Here we show that early inactivation core complex subunits Plasmodium falciparum leads to developmental arrest and accumulation cytosolic vesicles, indicating a role parasite endocytosis endosomes digestive vacuole membrane. Late led mislocalization luminal rhoptry microneme proteins, severe defect...
ABSTRACT Mature gametocytes of Plasmodium ( P .) falciparum display a banana (falciform) shape conferred by complex array subpellicular microtubules (SPMT) associated to the inner membrane (IMC). Microtubule proteins (MAPs) define MT populations and modulate interaction pellicular components. Several MAPs have been identified in Toxoplasma gondii homologues can be found genome species, but function these for asexual sexual development malaria parasites is still unknown. Here we novel MAP,...
ABSTRACT During the symptomatic human blood phase, malaria parasites replicate within red cells. Parasite proliferation relies on uptake of nutrients, such as amino acids, from host cell and plasma, requiring transport across multiple membranes. Amino acids are delivered to parasite through surrounding vacuolar compartment by specialized nutrient-permeable channels erythrocyte membrane parasitophorous vacuole (PVM). However, further acid plasma (PPM) is currently not well characterized. In...
Abstract Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum , an agent of human malaria, relies on membrane for the uptake nutrients from host, disposal metabolic waste, exchange metabolites between organelles and generation maintenance transmembrane electrochemical gradients its growth replication within erythrocytes. Despite their importance cellular physiology, functional a number remain unclear, which is...