A5086923003- Malaria Research and Control
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Invertebrate Immune Response Mechanisms
- Microtubule and mitosis dynamics
- Chromosomal and Genetic Variations
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Toxoplasma gondii Research Studies
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
Heidelberg University
2022-2025
Heidelberg University
2025
University Hospital Heidelberg
2023-2025
Microtubule inner proteins (MIPs) are microtubule-associated that bind to tubulin from the luminal side. MIPs can be found in axonemes stabilize flagellar beat or within cytoplasmic microtubules. Plasmodium spp. causative agents of malaria feature different parasite forms across a complex life cycle with both unique and divergent microtubule-based arrays. Here, we investigate four rodent for their role transmission mosquito. We show by single double gene deletions SPM1 TrxL1, associated...
Plasmodium sporozoites, the stage that initiates a malaria infection, must invade mosquito salivary glands (SGs) before transmitting to vertebrate host. However, effects of sporozoite invasion on gland physiology and saliva composition remain largely unexplored. We examined impact infection Anopheles gambiae using high-resolution proteomics, gene expression, morphological analysis. The data revealed differential expression various proteins, including enrichment humoral proteins in infected...
Mature gametocytes of Plasmodium falciparum display a banana (falciform) shape conferred by complex array subpellicular microtubules (SPMT) associated with the inner membrane (IMC). Microtubule-associated proteins (MAPs) define MT populations and modulate interaction pellicular components. Several MAPs have been identified in Toxoplasma gondii, homologues can be found genomes
Abstract Plasmodium sporozoite development in and egress from oocysts the Anopheles mosquito remains largely enigmatic. In a previously performed high‐throughput knockout screen, putative subunit 5 of prefoldin complex ( Pb PCS5, PBANKA_0920100) was identified as essential for parasite during liver stage development. Here we generated analyzed PCS5 line its mosquito. Interestingly, deletion does not significantly affect oocyst formation but leads to growth defect resulting aberrantly shaped...
<title>Abstract</title> <italic>Plasmodium </italic>parasites, the causative agents of malaria, undergo a crucial development within mosquito vector, initiated by formation male and female gametes from gametocytes. Male gametogenesis involves three rapid rounds endomitosis followed single round DNA segregation nuclear division during gamete budding. How cell organises eight genomes octoploid nucleus is currently unknown. Here, we discovered an atypical five-subunit Arp2/3 complex in...
Abstract The malaria-causing parasite Plasmodium has a complex life cycle involving both vertebrate and mosquito hosts. Sexual stages or gametocytes are the only stage competent for transmission to mosquitoes. Formation of flagellated male gametes from requires rapid rounds genome replication. Here we discovered non-canonical actin-related protein 2/3 (Arp2/3) essential DNA segregation during gametogenesis. Arp2/3 dynamically localizes within nucleus endomitotic spindles interacts with...
ABSTRACT Mature gametocytes of Plasmodium ( P .) falciparum display a banana (falciform) shape conferred by complex array subpellicular microtubules (SPMT) associated to the inner membrane (IMC). Microtubule proteins (MAPs) define MT populations and modulate interaction pellicular components. Several MAPs have been identified in Toxoplasma gondii homologues can be found genome species, but function these for asexual sexual development malaria parasites is still unknown. Here we novel MAP,...
Abstract Microtubule inner proteins, MIPs, are microtubule associated proteins that bind to tubulin from the luminal side. MIPs can be found in axonemes stabilize flagellar beat or within cytoplasmic microtubules. Plasmodium spp. causative agents of malaria feature different forms across a complex life cycle with both unique and divergent microtubule-based arrays. Here we investigate role four rodent parasite for their transmission mosquito. We show by single double gene deletions SPM1...