A5100345678- Melanoma and MAPK Pathways
- Estrogen and related hormone effects
- Carbohydrate Chemistry and Synthesis
- Cytokine Signaling Pathways and Interactions
- Organophosphorus compounds synthesis
- Microbial Natural Products and Biosynthesis
- Genetics and Plant Breeding
- Computational Drug Discovery Methods
- Genetic Mapping and Diversity in Plants and Animals
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Organic and Inorganic Chemical Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Metal complexes synthesis and properties
- Glycosylation and Glycoproteins Research
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Reactions
- 14-3-3 protein interactions
- Sulfur-Based Synthesis Techniques
- Mitochondrial Function and Pathology
- Advanced Breast Cancer Therapies
- Synthesis of Organic Compounds
- Phosphorus compounds and reactions
- DNA and Nucleic Acid Chemistry
Eastern University
2023
Nanjing University of Chinese Medicine
2023
Nantong University
2015-2022
Northeastern University
2014-2021
Institute of Crop Sciences
2021
Chinese Academy of Agricultural Sciences
1998-2021
Center for Life Sciences
2020
Universidad del Noreste
2020
Tsinghua University
1993-2020
Peking University
1999-2020
Abstract The development of a highly efficient and practical protocol for the direct CN coupling H‐tetrazole boronic acid was presented. A careful patient optimization variety reaction parameters revealed that this conventionally challenge could indeed proceed efficiently in very simple system, is, just by stirring tetrazoles acids under oxygen presence different Cu I or II salts with only 5 mol % loading DMSO at 100 °C. Most significantly, smoothly regiospecific manner to afford...
An efficient and environmentally friendly benzylation of arenes with benzyl ethers as donors using BF3–Et2O to generate in situ the superacid BF3–H2O an promotor has been described. A wide variety functional groups have investigated found be compatible give desired diarylmethanes yields up 99%. The crucial role moisture content this transformation demonstrated by detailed investigations.
A convergent synthesis of 5a-carbasugar analogues the n-Pr-variant SL0101 is described. The were synthesized in an effort to find compounds with potent vivo efficacy inhibition p90 ribosomal s6 kinase (RSK1/2). derived desired C-4 L-rhamnose stereochemistry from quinic acid and used a highly selective cuprate addition, NaBH4 reduction, Mitsunobu inversion, alkene dihydroxylation install remaining stereochemistry. Pd-catalyzed cyclitolization stereoselectively installed aglycon at anomeric...
Hepatocellular carcinoma (HCC) results in large amounts of deaths each year worldwide. To develop more effective treatments for HCC, it is very necessary to define the molecular mechanisms hepatocarcinogenesis. Mixed lineage kinase (MLK)-4 a member MLK family mitogen-activated protein kinases, and modulates different cellular responses. However, its role meditation HCC progression remains unclear. In study, we found that MLK4 was over-expressed tumor samples patients. High expression...
In response to estrogens, estrogen receptor alpha (ERα), a critical regulator of homeostasis, is degraded through the 26S proteasome. However, despite continued presence before menopause, ERα protein levels are maintained. We discovered that ERK1/2-RSK2 activity oscillates during estrous cycle. high levels, ERK1/2 activated and phosphorylates drive degradation estrogen-responsive gene expression. Reduction results in deactivation. RSK2 maintains redox which prevents sustained activation....
An asymmetric synthesis of two analogues SL0101 (1) has been achieved. The effort is aimed at the discovery inhibitors p90 ribosomal S6 kinase (RSK) with improved bioavailability. route relies upon use Taylor catalyst to regioselectively install C-3″ acetyl or carbamate functionality. This study led identification a third-generation analogue C-4″ n-Pr-carbamate and acetate RSK inhibitory activity.
The synthesis of two series five kaempfer-3-ols was described. first set all have a C-3 hydroxyl group and the second has carboxymethoxy ether at position. Both variable substitution C-4′ position (i.e., OH, Cl, F, H, OMe). kaempferols ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity cancer cell proliferation.
Journal Article B region variant of the estrogen receptor gene Get access Jack A. Taylor, Taylor Search for other works by this author on: Oxford Academic PubMed Google Scholar Yu Li, Li 1The University North Carolina School MedicineChapel Hill, NC, USA Ming You, You 2The Medical College OhioToledo, OH, Allen J. Wilcox, Wilcox Edison Liu Nucleic Acids Research, Volume 20, Issue 11, 11 June 1992, Page 2895, https://doi.org/10.1093/nar/20.11.2895 Published: 1992 history Received: 09 April
The <italic>de novo</italic> asymmetric synthesis of carbohydrates for the SAR-study anticancer natural product, SL0101.
We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, cell lysates and when incorporated histone peptides.
Identifying isoform-specific inhibitors for closely related kinase family members remains a substantial challenge. The necessity achieving this specificity is exemplified by the RSK family, downstream effectors of ERK1/2, which have divergent physiological effects. natural product, SL0101, flavonoid glycoside, binds specifically to RSK1/2 through binding pocket generated an extensive conformational rearrangement within N-terminal domain (NTKD). In modelling experiments single amino acid that...
Abstract Four phosphonodipeptides containing 1-aminoalkylphosphonate were synthesized by applying four different coupling methods. One of them was then converted into monoacid, ethyl hydrogen 1-(N-acetyl-prolyl)amino-2-phenylethyl phosphonate. Three 1-amino-2-phenylethylphosphonamidate also prepared converting phosphono monoacid phosphonochloridate and reacting it with amino acid ester. Benzyl ethoxyphosphonyl-glycyl-glycine ester from glycylglycinate benzylphosphonochloridate derived direct...
Abstract Diphyllin and its natural derivatives were identified as potent vacuolar H + ‐ATPase (V‐ATPase) inhibitors. In this study, twelve 2, 4, 5‐trideoxyhexopyranosides of diphyllin synthesized. Most these compounds showed abilities to inhibit the growth HT‐29, MCF‐7, HepG2 cancer cells with IC 50 values at submicromolar concentration. The 5c3 5c4 best inhibitory activity on breast cell lines MCF‐7 0.09 0.10 μM. Compounds similar V‐ATPase potency diphyllin. Molecular docking that a...