A5081832968- Agricultural and Food Sciences
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Phytochemistry Medicinal Plant Applications
- Fatty Acid Research and Health
- Diet and metabolism studies
- Sensory Analysis and Statistical Methods
- Heavy Metals in Plants
- Natural Antidiabetic Agents Studies
- Nuts composition and effects
- Histone Deacetylase Inhibitors Research
- Phytochemicals and Antioxidant Activities
- Botanical Research and Applications
- Cancer-related gene regulation
- Food, Nutrition, and Cultural Practices
- Bee Products Chemical Analysis
- Sesame and Sesamin Research
- Esophageal Cancer Research and Treatment
- Gut microbiota and health
- Food composition and properties
- Consumer Attitudes and Food Labeling
- Nutritional Studies and Diet
- Natural Compound Pharmacology Studies
- Heavy Metal Exposure and Toxicity
Universidade Federal de Mato Grosso do Sul
2014-2024
Instituto Português de Oncologia Francisco Gentil
2018-2024
IPO Porto
2018-2024
University of Évora
2023
Universidade Católica Dom Bosco
2012-2020
Universidade Federal do Paraná
2017
Covalent RNA modifications, such as N-6-methyladenosine (m6A), have been associated with various biological processes, but their role in cancer remains largely unexplored. m6A dynamics depends on specific enzymes whose deregulation may also impact tumorigenesis. Herein, we assessed the differential abundance of m6A, its writer VIRMA and reader YTHDF3, testicular germ cell tumors (TGCTs), looking for clinicopathological correlates. In silico analysis TCGA data disclosed altered expression...
Testicular germ cell tumours (TGCTs) are a heterogeneous group of neoplasms, mostly affecting young men. Curability rates high and adequate treatment relies on careful accurate pathological clinical assessment. Indeed, TGCTs' histopathological subtyping is critical for therapeutic decision. Considering the limitation currently available serum biomarkers, novel candidates have been proposed, most notably miR-371a-3p, which outperformed classical markers, but no detailed information concerning...
Background: The immune infiltrate plays an important part in testicular germ cell tumors, but it remains scarcely studied. We aimed at thoroughly characterizing the and expression of checkpoints PD-L1/CTLA-4 mismatch repair (MMR) proteins these neoplasms, seeking for associations with patient outcome. Methods: A total 162 consecutively diagnosed patients (2005–2018) were included. Immunostaining PD-L1, CTLA-4 MMR was independently assessed both cells (ICs) tumor (TCs) primary tumors...
Abstract Esophageal squamous cell carcinoma (ESCC), the most frequent esophageal cancer (EC) subtype, entails dismal prognosis. Hypoxia, a common feature of advanced ESCC, is involved in resistance to radiotherapy (RT). RT response hypoxia might be modulated through epigenetic mechanisms, constituting novel targets improve patient outcome. Post-translational methylation histone can partially by lysine demethylases (KDMs), which specifically removes methyl groups certain residues. KDMs...
Germ cell tumors (GCTs) are developmental cancers, tightly linked to embryogenesis and germ development. The recent expanding field of RNA modifications is being increasingly implicated in such molecular events, as well tumor progression resistance therapy, but still rarely explored GCTs. In this work, a follow-up our study on topic TGCT tissue samples, we aim investigate the role N6-methyladenosine (m6A), most abundant mRNA, vitro vivo models representative tumors.Four lines GCTs (three...
This study evaluated the nutritional value of sesame and flaxseed oils their effects on lipid glucose profile rats fed diets containing different fat combinations. Fatty acid composition, refractive index, iodine saponification values were analyzed to characterize oils. In biological assay, Wistar diets, whose composition consisted varying combinations oil, animal fat. The primary constituents oil oleic (28.6%), linoleic (28.4%), lauric (14.6%); for they alpha-linolenic (39.90%), (17.97%)...
Aim: Assess differential patterns of selected five genes' promoter methylation among testicular germ cell tumors (TGCT) subtypes. Materials & methods: CRIPTO, HOXA9, MGMT, RASSF1A and SCGB3A1 levels were evaluated by quantitative methylation-specific PCR in 161 TGCT 16 controls. Associations between clinicopathological parameters assessed, receiver operating characteristics curve analysis was performed. Results: Promoter CRIPTO/HOXA9/SCGB3A1 panel best discriminated controls nonseminomatous...
Consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) is related to improvement in the inflammatory response associated with decreases metabolic disorders obesity, such as low-grade inflammation and hepatic steatosis. Linseed (Linum usitatissimum) oil a primary source n-3 (FAs) plant origin, particularly α-linolenic acid, provides an alternative for ingestion PUFA by persons allergic to, or wishing avoid, animal sources. In our study, we evaluated effect consumption different...