A5024252027- Natural Antidiabetic Agents Studies
- Antioxidant Activity and Oxidative Stress
- Essential Oils and Antimicrobial Activity
- Venomous Animal Envenomation and Studies
- Phytochemistry and Biological Activities
- Diet and metabolism studies
- Phytochemistry Medicinal Plant Applications
- Phytochemicals and Antioxidant Activities
- Reproductive System and Pregnancy
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Lichen and fungal ecology
- Ginger and Zingiberaceae research
- Microbial Metabolites in Food Biotechnology
- Liver Disease Diagnosis and Treatment
- Entomological Studies and Ecology
- Diet, Metabolism, and Disease
- Bioactive Natural Diterpenoids Research
- Magnolia and Illicium research
- Fatty Acid Research and Health
- Botany, Ecology, and Taxonomy Studies
- TGF-β signaling in diseases
- Infectious Diseases and Mycology
- Biochemical Analysis and Sensing Techniques
- Pain Mechanisms and Treatments
Universidade Federal de Mato Grosso do Sul
2014-2025
Universidade de São Paulo
2007
Consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) is related to improvement in the inflammatory response associated with decreases metabolic disorders obesity, such as low-grade inflammation and hepatic steatosis. Linseed (Linum usitatissimum) oil a primary source n-3 (FAs) plant origin, particularly α-linolenic acid, provides an alternative for ingestion PUFA by persons allergic to, or wishing avoid, animal sources. In our study, we evaluated effect consumption different...
Tabebuia aurea (Silva Manso) Benth. & Hook. f. ex S. Moore is used as anti-inflammatory, analgesic and antiophidic in traditional medicine, though its pharmacological proprieties are still underexplored. In the bothropic envenoming, pain a key symptom drove by an intense local inflammatory neurotoxic event. The antivenom serum therapy main treatment despite poor effects against tissue injury. Furthermore, it limited to ambulatorial niches, giving space for search of new more inclusive...
Annona muricata Linn, commonly known as graviola, is one of the most popular plants used in Brazil for weight loss. The aim this study to evaluate therapeutic effects three different doses (50 mg/kg, 100 and 150 mg/kg) aqueous graviola leaf extract (AGE) supplemented by oral gavage, on obese C57BL/6 mice. Food intake, body weight, an glucose tolerance test (OGTT), insulin sensitivity test, quantification adipose tissue cytokines, fat pads, serum biochemical histological analyses liver,...
This study evaluated the effects of dietaries formulated with kernel oil Acrocomia aculeata (AKO), rich in medium chain fatty acids (MCFA), as partial substitute carbohydrate calories upon blood glucose, lipid profile, insulin secretion and sensitivity diabetic rats. Overall, dietary any AKO dose reduced hyperglycemia, ameliorated secretion, lowered resistance by model HOMA-IR HOMA-β augmented pancreatic beta cells functionality, restored number β-cell rats increased it non-diabetic In...
Lichens have exhibited numerous biological activities, including growth inhibition of tumor cells.This study evaluated the antiproliferative activity hypostictic and salazinic acids against cell lines (B16-F10, PC-03, MCF7, HT-29, HEP-G2, K562 786-0) by SRB assay in vitro antitumor experimental murine melanoma vivo.Activation caspase-3 was quantified flow cytometry.The model B16-F10 used BALB/c mice for evaluation activity.Hypostictic acid showed significant cells (GI50 2.20 M), 13.78 M)...
Problem Cells responsible for the synthesis of follistatin and activin A in pregnant mouse endometrium have not been characterized. Method study Immunocytochemistry was used to determine distribution uterus. Results Follistatin detected prior decidualization embryo implantation. seen fully decidualized cells, being restricted non-decidualized fibroblasts cells process decidualization. In contrast, exclusively mature antimesometrial decidual during involution. After day eleven pregnancy, both...
Problem Identification of the cell types responsible for synthesis decidual prolactin‐related protein (dPRP) in pregnant mouse endometrium. Method study Histochemistry and immunocytochemistry were used to determine peri‐implantation dPRP perlecan distribution uterus. Results We identified pre‐decidual mature cells from days 5 12 pregnancy. On day 8, immunoreactivity was detected within cytoplasmic granules a specific population granulated (GDCs). In mesometrial cells, weak seen 7 14. Between...
The prevalence of gastrointestinal disorders, such as constipation, has been increasing. Genetic factors and lifestyle are some the etiologies this issue, affecting health population. Natural products have properties that contribute to maintenance promotion, including reduction inflammatory process. Hancornia speciosa, popularly known mangaba, is an abundant native fruit in Brazilian Cerrado, commercialized for culinary purposes used because its pharmacological properties. objective study...
The aim of this study is to evaluate the efficacy Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This evaluated obesity, insulin resistance, dyslipidemia hepatic steatosis induced by a diet Swiss mice. Cellular parameters macrophages, such as cell viability (MTT), production release nitric oxide (NO) hydrogen peroxide (H2O2), spreading, adhesion phagocytosis were determined. Our results showed that treatment with B. prevented...
Abstract Metabolic syndrome (MetS) and obesity are growing in many parts of the world, becoming public health problems. It is proposed that foods with functional properties can assist treatment these diseases. Crude buriti pulp oil (BPO) a food traditionally consumed by residents Pantanal, Cerrado Brazilian Amazon. rich oleic acid, tocopherols carotenoids, emerging as potential food. Thus, this study aimed to evaluate effect supplementation BPO on metabolic disorders caused high‐fat diet....
Purpose To develop a model of induction type-2 diabetes (DM2) by combining low doses streptozotocin (STZ) and cafeteria diet. Methods Forty male Wistar rats (200 g) were allocated into four groups: control (non-diabetic, n = 10); STZ 30 mg/kg (diabetic, 35 (diabetic,n 40 10). DM2 was induced with single intraperitoneal injection after weeks diet in the three diabetic groups. All animals evaluated as for anthropometric, biochemical analyses, well liver, kidney pancreas histological analyses....
Oils extracted from almonds are often used with particular interest due to their prospective health effects and benefits. Tucum is a Pantanal fruit widely consumed by local population no in vivo toxicity studies regarding its safety available the literature date. This study investigated acute subacute of tucum almond oil (TAO) mice evaluating profile. For (2000 mg/kg) (250, 500 1000 studies, TAO was administered orally according 425 407 Organization for Economic Cooperation Development...
Abstract Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder caused by excess consumption of hypercaloric foods. Guavira ( Campomanesia sp.) pulp has broad technological applicability, yet the peel and seeds are considered industrial residue. The objective this unprecedented study was to evaluate effects flour from guavira's residue (GF) in rats fed with diet (HD). During 65 days, 50 were separated into control group: 1%, 2%, 4% 8% HD GF complementation diet. chemical...
This study aimed to resveratrol supplementation (at 5 or 10 mg/kg) and a hydroethanolic extract of canjiqueira fruits (150 on female SWISS mice. Total cholesterol, high-density lipoprotein (HDL), triglyceride levels, gestation rates, embryonic implantation rates in their Offspring was evaluated. In conclusion, the consumption fruit altered lipid profile offspring, did not impact reproductive performance. Supplementing mice with mg/kg increased total triglycerides, HDL thereby enhancing...