A5100759994- Antimicrobial Peptides and Activities
- Venomous Animal Envenomation and Studies
- Oral microbiology and periodontitis research
- Biochemical and Structural Characterization
- RNA Interference and Gene Delivery
- Olfactory and Sensory Function Studies
- Cassava research and cyanide
- Infection Control and Ventilation
- Biological Research and Disease Studies
- Aquaculture disease management and microbiota
- Genetic Associations and Epidemiology
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Infrared Thermography in Medicine
- RNA modifications and cancer
- Reliability and Agreement in Measurement
- Oral Health Pathology and Treatment
- Insect and Pesticide Research
- Health, psychology, and well-being
- Fiber-reinforced polymer composites
- Therapeutic Uses of Natural Elements
- Dental Research and COVID-19
- Epigenetics and DNA Methylation
Universidade Federal de Minas Gerais
2020-2024
Weill Cornell Medicine
2023
Harvard University
2020-2023
Cornell University
2023
Nanjing University of Aeronautics and Astronautics
2022
University of Aveiro
2022
Federal Center for Technological Education of Minas Gerais
2022
National Natural Science Foundation of China
2022
Commercial Aircraft Corporation of China (China)
2022
Bridge University
2022
Selective anticancer cell activity for both cell-penetrating and cationic antimicrobial peptides has previously been reported. As crotamine possesses activities similar to of these, this study investigates crotamine's toxicity in vitro vivo.In cancer viability was evaluated after treatment with 1 5 μg/ml crotamine. In vivo cytotoxic effects C57Bl/6J mice bearing B16-F10 primary cutaneous melanoma were tested, two groups each containing 35 mice. The crotamine-treated group received μg/day per...
Our goal was to demonstrate the in vivo tumor specific accumulation of crotamine, a natural peptide from venom South American rattlesnake Crotalus durissus terrificus, which has been characterized by our group as cell penetrating with high specificity for actively proliferating cells and concentration-dependent cytotoxic effect. Crotamine cytotoxicity shown be dependent on disruption lysosomes subsequent activation intracellular proteases. In this work, we show that effect crotamine also...
Abstract Esophageal squamous cell carcinoma (ESCC), the most frequent esophageal cancer (EC) subtype, entails dismal prognosis. Hypoxia, a common feature of advanced ESCC, is involved in resistance to radiotherapy (RT). RT response hypoxia might be modulated through epigenetic mechanisms, constituting novel targets improve patient outcome. Post-translational methylation histone can partially by lysine demethylases (KDMs), which specifically removes methyl groups certain residues. KDMs...
To assess the self-perception of breath odour (SPBO) and oral hygiene habits (OHHs) while wearing face masks during COVID-19 pandemic.This cross-sectional study included 4647 individuals who answered a structured questionnaire containing demographic, medical dental variables self-perceived odour. Variables associated with changes in odour, halitosis OHHs were assessed through multivariate logistic regression.Changes reported by 1572 smoking, systemic conditions, dry mouth, tongue coating,...
Introduction: Bichectomy promotes reduction of cheek volume by partial removal the buccal fat pad. Like any other surgical procedure, there are inherent risks that can lead to severe complications. To minimize those risks, a novel approach using real-time ultrasonography (US) imaging during procedure was performed on difficult bichectomy case with anatomical variation in pad position.
Abstract Background To assess the reporting of certainty evidence using GRADE approach in systematic reviews interventions pediatric dentistry. Methods The inclusion criteria were randomized clinical trials (RCTs) and non-randomized studies (NRSIs) dentistry that reported through approach. Paired independent reviewers screened studies, extracted data, appraised methodological quality Assessing Methodological Quality Systematic Reviews (AMSTAR 2) tool. was for each outcome. A descriptive...
ABSTRACT Objectives To validate a straightforward single-cell passaging cultivation method that enables high-quality maintenance of hiPSC without the appearance karyotypic abnormalities or loss pluripotency. Methods Cells were kept in culture for over 50 passages, following structured chronogram passage and monitoring cell growth by population doubling time (PDT) calculation confluence. Standard procedures iPSC as embryonic body (EB) formation, karyotyping pluripotency markers expression...
Abstract Background While polygenic risk scores hold significant promise in estimating an individual’s of developing a complex trait such as obesity, their application the clinic has, to date, been limited by lack data from non-European populations. As collaboration model International Hundred K+ Cohorts Consortium (IHCC), we endeavored develop globally applicable trans-ethnic PRS for body mass index (BMI) through this relatively new international effort. Methods The was developed trained...