A5042183935- Venomous Animal Envenomation and Studies
- Antimicrobial Peptides and Activities
- Amphibian and Reptile Biology
- Rabies epidemiology and control
- Marine Sponges and Natural Products
- Healthcare and Venom Research
- Insect and Pesticide Research
- Neurobiology and Insect Physiology Research
- Echinoderm biology and ecology
- Bee Products Chemical Analysis
- Biochemical and Structural Characterization
- Vector-borne infectious diseases
- Cholinesterase and Neurodegenerative Diseases
- Marine Invertebrate Physiology and Ecology
- Nicotinic Acetylcholine Receptors Study
- Entomological Studies and Ecology
- Allergic Rhinitis and Sensitization
- Computational Drug Discovery Methods
- Protein Hydrolysis and Bioactive Peptides
- Marine Toxins and Detection Methods
- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- vaccines and immunoinformatics approaches
- Cellular transport and secretion
- Alzheimer's disease research and treatments
Universidade São Francisco
2018-2025
Natura (Brazil)
2023-2024
Instituto Butantan
2013-2023
Santa Casa da Misericórdia de Bragança Paulista
2023
Universidade Cidade de São Paulo
2020
University of St. Francis
2020
Instituto de Pesquisas Energéticas e Nucleares
2020
Universidade de São Paulo
2011-2013
Universidade Federal de São Paulo
2009
Apis mellifera venom is comprised basically of melittin, phospholipase A(2), histamine, hyaluronidase, catecholamine and serotonin. Some these components have been associated with allergic reactions, amongst several other symptoms. On the hand, bee mass stinging, caused by Africanized honey (AHB), increasingly becoming a serious public health issue in Brazil; therefore, development efficient serum-therapies has become necessary. In this work, we analyzed composition AHB Brazil through one...
Amphibians are known by cutaneous glands, spread over the skin, containing toxins (proteins, peptides, biogenic amines, steroidal bufadienolides, and alkaloids) used as chemical defense against predators microbial infection. Toads characterized presence of parotoid macroglands. The common toads have lately been divided into two genera: Bufo (Europe, Asia, Africa) Rhinella (South America). Basal Rhaebo genus is exclusively Central America Amazon region. Although related, species may share...
Amphibians have many skin poison glands used in passive defense, which the aggressor causes its own poisoning when biting prey. In some amphibians accumulate certain regions forming macroglands, such as parotoids of toads. We discovered that toad Rhaebo guttatus is able to squirt jets towards aggressor, contradicting typical amphibian defense. studied R. chemical comparing it with Rhinella marina, a sympatric species showing found only parotoid adhered scapula and do not calcified dermal...
Huntington's disease (HD) is considered a rare and fatal neurodegenerative disease; despite that, only one study described the outcomes among those with HD COVID-19. In this context, an epidemiological investigation was conducted in Brazil using data from OpenDataSUS (https://opendatasus.saude.gov.br/), Brazilian open dataset encompassing demographic clinical information of hospitalized patients. The comprised 2,180,403 patients due to COVID-19 December 29th, 2019, April 6th, 2023. From...
Abstract In amphibians, secretions of toxins from specialized skin poison glands play a central role in defense against predators. The production toxic is often associated with conspicuous color patterns that warn potential predators, as it the case many dendrobatid frogs, including Ameerega picta . This species resembles presumably nontoxic Leptodactylus lineatus study tests for mimicry by studying morphology and distribution glands, components secretion, defensive behavior. Dorsal was...
Rabies is a fatal zoonotic neglected disease that occurs in more than 150 countries, and kills 55.000 people every year. It caused by an enveloped single stranded RNA virus affects the central nervous system, through infection initiated muscular nicotinic acetylcholine receptor, according to many authors. Alkaloids, such as acetylcholine, are widespread molecules nature. They present numerous biological fluids, including skin secretion of amphibians, which they act (together with proteins,...
Amphibian defence against predators and microorganisms is directly related to cutaneous glands that produce a huge number of different toxins. These are distributed throughout the body but can form accumulations in specific regions. When grouped low numbers, poison structures similar warts, quite common dorsal skin bufonids (toads). accumulated large constitute protuberant known as macroglands, among which parotoids most ones. This work aimed at morphological biochemical characterization...
Apis mellifera, the European honey bee, is perhaps most studied insect in Apidae family. Its venom comprised basically of melittin, phospholipase A(2), histamine, hyaluronidase, cathecolamines and serotonin. Some these components have been associated to allergic reactions, among several other symptoms. On hand, bee mass-stinging increasingly becoming a serious public health issue; therefore, development efficient serum-therapies has become necessary, with consequent better characterization...
The eastern brown snake is the predominant cause of snakebites in mainland Australia. Its venom induces defibrination coagulopathy, renal failure and microangiopathic hemolytic anemia. Cardiovascular collapse has been described as an early death patients, but, so far, mechanisms involved have not fully identified. In present work, we analysed venome Pseudonaja textilis by combining high throughput proteomics transcriptomics, aiming to further characterize components this venom. combination...
The hard tick Hyalomma dromedarii is one of the most injurious ectoparasites affecting camels and apparently best adapted to deserts. As long-term blood feeders, ticks are threatened by host defense system compounds that can cause them be rejected and, ultimately, die. However, their saliva contains a cocktail bioactive molecules enables succeed in taking meal. A recent sialotranscriptomic study uncovered complexity salivary composition H. provided database for proteomic analysis. We carried...
Bradykinin (BK) and its related peptides are widely distributed in venomous animals, including wasps. In fact, we have previously purified a novel BK-related peptide (BRP) named Cd-146 the threonine(6)-bradykinin (Thr(6)-BK) from venom of solitary wasp Cyphononyx fulvognathus. Further survey this same extract allowed structural characterization two other BRPs, here as fulvonin cyphokinin. Biochemical performed showed that although high primary structure similarity observed with BK, these not...
The investigation of venoms has many clinical, pharmacological, ecological and evolutionary outcomes. Crotalus spp. venom can cause hemorrhage, neurotoxicity, myotoxicity, coagulopathy hypotension. Although neurotoxicity hemorrhage usually does not occur for the same species, rare Venezuelan species vegrandis presents both characteristic. Different from other it a restricted niche geographical distribution. Nevertheless, raising medical importance as this rattlesnake population is...
Rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by lyssavirus. Animal venoms and secretions have long been studied new bioactive molecular sources, presenting wide spectrum of biological effects, including antiviral agents. Bufotenine, for instance, alkaloid isolated from the skin secretion anuran Rhinella jimi that inhibits cellular penetration rabies virus. Antimicrobial peptides, such ocellatin-P1...
Abstract Tetrodotoxin (TTX), one of the most toxic substances in nature, is present bacteria, invertebrates, fishes, and amphibians. Marine organisms seem to bioaccumulate TTX from their food or acquire it symbiotic but its origin amphibians unclear. Taricha granulosa can exhibit high levels, presumably concentrated skin poison glands, acting as an agent selection upon predatory garter snakes ( Thamnophis ). This co-evolutionary arms race induces variation T. very undetectable. Using...
Amphibians are known for their skin rich in glands containing toxins employed passive chemical defense against predators, different from, example, snakes that have active defense, injecting venom into the prey. Caecilians (Amphibia, Gymnophiona) snake-shaped animals with fossorial habits, considered one of least vertebrate groups. We show here amphibian caecilians, including species from basal groups, besides having cutaneous poisonous as other amphibians do, possess specific at base teeth...
We investigated the morphology of skin and biochemistry lipids in secretion Bokermannohyla alvarengai, a montane treefrog that is known to bask regularly, motionless full sunlight for extended periods time. Our primary goal was identify structural biochemical modifications might assist this frog species accommodate conflicting demands heat exchange water balance while basking. The modulation basking B. alvarengai involves changes coloration. found response supported by prominent monolayer...
Abstract Amphibian skin is rich in mucous glands and poison glands, secreting substances important for gas exchange playing a fundamental role chemical defense against predators microorganisms. In the caecilian Siphonops annulatus (Mikan, 1920) we observed concentration of enlarged head region. posterior region body similar made up glands. These accumulations structurally resemble macroglands previously reported anurans salamanders. The these regions are each surrounded by collagen walls...