A5016671084- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Lysosomal Storage Disorders Research
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Single-cell and spatial transcriptomics
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- Malaria Research and Control
- Autophagy in Disease and Therapy
- Animal Genetics and Reproduction
- Acute Myeloid Leukemia Research
- Neurological and metabolic disorders
- Erythrocyte Function and Pathophysiology
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Gut microbiota and health
- Helminth infection and control
- Mosquito-borne diseases and control
- Metabolism and Genetic Disorders
Qassim University
2024-2025
Great Ormond Street Hospital
2022-2023
University College London
2021-2023
Kuwait University
2021
Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons substantia nigra, and aggregation α-synuclein. The sequence molecular events that proceed from an mutation during development, to end-stage pathology is unknown. Utilising human-induced pluripotent stem cells (hiPSCs), we resolved temporal SNCA- induced pathophysiological order discover early, likely causative, events. Our small molecule-based protocol generates highly...
Viral vectors restore dopamine transporter function and ameliorate neuropathology in iPSC-derived neurons a mouse model of infantile parkinsonism.
Abstract Mosquitoes are one of the most significant vectors diseases worldwide. They can transmit many viral and parasitic to humans animals. A survey was conducted in ten areas Buraydah City investigate prevalence distribution mosquitoes area. The study involved collection adult using Blackhole light traps over a year, from January December 2021. During this period, total 23,346 were collected analyzed as part survey. results showed presence several mosquito species, including Aedes aegypti...
The presence of mosquitoes in a certain area is sufficient evidence the transmission diseases, addition to inconvenience and harassment they cause population. In order for mosquito control be successful, there must reports information about extent distribution spread this area. This study was conducted seasonally calculate abundance initially detect hepatitis C virus most abundant species collected some localities: Kafr Saqr (Hanot, El-Kodah, Abo Shokok, El-Hagarsa); Kebeer (Manshat Radwan,...
Aromatic l-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological disorder of monoamine synthesis which results in dopamine and serotonin deficiency. The majority affected individuals have variable, though often severe cognitive motor delay, with movement high risk premature mortality. For most, standard pharmacological treatment provides only limited clinical benefit. Promising gene therapy approaches are emerging, may not be either suitable or easily accessible for...
Abstract Argininosuccinate lyase (ASL) is integral to the urea cycle detoxifying neurotoxic ammonia and nitric oxide (NO) biosynthesis cycle. Inherited ASL deficiency causes argininosuccinic aciduria (ASA), a rare disease with hyperammonemia NO deficiency. Patients present developmental delay, epilepsy movement disorder, associated NO‐mediated downregulation of central catecholamine biosynthesis. A neurodegenerative phenotype has been proposed in ASA. To better characterise this ASA, we...
Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with progressive loss of dopaminergic neurons substantia nigra, and accumulation aggregates α-synuclein. However, sequence molecular events that proceed from mutation during development, to its end stage pathology is unknown. Utilising human induced pluripotent stem cells (hiPSCs) mutations, we resolved temporal pathophysiological occur neuronal differentiation order discover early, likely causative,...