A5100441979- Organoselenium and organotellurium chemistry
- Chemical Synthesis and Analysis
- Alkaloids: synthesis and pharmacology
- Nanocluster Synthesis and Applications
- Click Chemistry and Applications
- Advanced Nanomaterials in Catalysis
- Berberine and alkaloids research
- Catalytic Cross-Coupling Reactions
- Cyclization and Aryne Chemistry
- X-ray Diffraction in Crystallography
- Phytochemical Studies and Bioactivities
- Selenium in Biological Systems
- Crystallization and Solubility Studies
- Circular RNAs in diseases
- Advanced Battery Materials and Technologies
- COVID-19 Impact on Reproduction
- Catalytic Alkyne Reactions
- Redox biology and oxidative stress
- Microbial Inactivation Methods
- Metal complexes synthesis and properties
- Quinazolinone synthesis and applications
- Ferrocene Chemistry and Applications
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Electrochemical Analysis and Applications
Inner Mongolia University
2025
Max Planck Institute of Molecular Physiology
2023-2024
Hebei University
2023
Beijing University of Chemical Technology
2022-2023
Guangxi Medical University
2023
Anhui Agricultural University
2022
Chinese Academy of Agricultural Sciences
2022
Ministry of Agriculture and Rural Affairs
2022
Institute of Animal Sciences
2022
Beibu Gulf University
2015-2022
Abstract The efficient exploration of biologically relevant chemical space is essential for the discovery bioactive compounds. A molecular design principle that possesses both biological relevance and structural diversity may more efficiently lead to compound collections are enriched in diverse bioactivities. Here pseudo-natural product (PNP) strategy, which combines PNP concept with synthetic diversification strategies from diversity-oriented synthesis, reported. collection was synthesized...
The optimization of batteries is a challenge for sustainable human development. Batteries have played pivotal role in reducing greenhouse gas emissions across diverse sectors, including light and heavy transportation, power generation, stationary energy storage, industrial processes, thereby mitigating environmental pollution. Despite these advancements, comprehensive understanding battery operational processes remains elusive. Critical aspects, such as reaction mechanisms, side reactions,...
For targeted covalent protein modification at low reactivity aspartates and glutamates, new methods are in high demand. Inspired by the HaloTag technology we have developed a technique which employs reaction between chloroalkane-functionalised ligands specific glutamate residue. The lipoprotein chaperone PDEδ shuttles prenylated lipoproteins cellular membranes and, thereby, mediates their activity. In cells, reversible inhibition is efficiently counterbalanced Arl2/3-mediated inhibitor...
Bacillus cereus sensu lato ( B. sl ) is important spoilage bacteria causing milk structure and flavor changes ubiquitous in the environment. This study addresses biodiversity, toxicity, proteolytic activity of from 82 environmental samples 18 raw bovine a dairy farm region Tianjin. In sum, 47 isolates were characterized through biochemical tests, 16S rRNA gene sequencing, panC analysis. Fourteen sequence types (STs) found samples, five new STs (ST2749, ST2750, ST2751, ST2752, ST2753)...
S -adenosyl- L -methionine (SAM), a sulfonium-based cofactor, plays an important role in numerous biological processes as methyl donor. Inspired by the function of sulfonium motif this nature’s synthetic toolkit, we here present aryne-activation strategy that intermediates situ generated from thioethers display unique reactivity toward alkyl group transposition. Experimental and theoretical studies indicate reaction occurs intermolecular fashion where TfO − -incorporated [K(18-crown-6)]...
Abstract Aryne chemistry is a powerful synthetic technique that forms new bonds to aromatic rings. The recent resurgence of aryne-based multicomponent coupling strategies has led an influx methodologies for the mild synthesis arene derivatives. In particular, these innovative discoveries broaden and streamline approaches toward phenol ether motifs, which are prevalent structural component across broad range related research fields. Herein, this review aims provide comprehensive overview...
De novo combination of natural product (NP) fragments by means efficient, complexity- and stereogenic character-generating transformations to yield pseudo-natural products (PNPs) may explore novel biologically relevant chemical space. Pyrrolidine- tetrahydroquinoline rarely occur in nature, such that PNPs embody both might represent NP-inspired matter endowed with bioactivity. We describe the synthesis pyrrolo[3,2-c]quinolines a highly enantioselective intramolecular exo-1,3-dipolar...
Many circular RNAs (circRNAs) have been identified to be associated with hepatocellular carcinoma (HCC) progression. We aim explore the diagnostic potential, functions, and mechanism of circELMOD3 in HCC. Differentially expressed circRNAs HCC its paired adjacent tissues were by RNA sequencing. was downregulated related clinicopathological characteristics patients. Additionally, plasma shown a highly sensitive non-invasive biomarker distinguish from healthy controls. Functional assays showed...
A supramolecular artificial glutathione peroxidase (PNIPAM-CD-g-Te) was prepared based on a graft copolymer. PNIPAM-CD-g-Te constructed by host-guest self-assembly. Significantly, displayed noticeable temperature-dependent catalytic activity and typical saturation kinetics behavior. It also proved that the change in self-assembled structure of during process played significant role The construction copolymer endows GPx with ability, enriched centers, homogeneously distributed centers. This...
Pharmacognosy Magazine ,2019,15,61,238-243.DOI:10.4103/pm.pm_364_18Published:March 2019Type:Original Article Authors:Ruirui Zhang, Minyan Dang, Shoutian Qiu, Hongyan Gu, Pingping He, Gang Guo, and Tao Zhang Author(s) affiliations:Ruirui Zhang1, Dang2, Qiu3, Gu3, He3, Guo2, Zhang4 1Department of Critical Care Medicine, 521 Healthy Institutes North Industries, Xi'an, Shaanxi, Malaysia. 2Innoscience Research Sdn Bhd, Subang Jaya, Selangor, 3Department Pharmacy, Binzhou Central Hospital...
Monoterpene indole alkaloids (MIAs) are endowed with high structural and spatial complexity characterized by diverse biological activities. Given this complexity-activity combination in MIAs, rapid efficient access to chemical matter related similar these would be highly desirable, since such compound classes might display novel bioactivity. We describe the design synthesis of a pseudo-natural product (pseudo-NP) collection obtained unprecedented MIA fragments through complexity-generating...
A microgel-based biomimetic glutathione peroxidase with temperature responsive catalytic behavior is synthesized by integrating atom transfer radical polymerization (ATRP) technology into one-pot synthesis.
A study of bicyclic tetramates modified with a bulky ester, which leads to steric hindrance distal chelating atoms as route for the alteration metal binding ability is reported. This approach required development direct method synthesis different esters cysteine from cystine, then provided access by Dieckmann cyclisation. Further derivation ketones and carboxamides Grignard addition transamination reactions respectively rapid chemical library diverse substitution. Of interest that tetramate...
The synthesis, structural, and antibacterial evaluation of bicyclic tetramate derivatives cysteine rendered hydrophilic with pendant heterocyclic substituents is reported; effective synthetic protocols activity for a small library polar were found, direct evidence strong metal chelation in these systems was obtained. A computational study has developed detailed understanding the controlling factors key Dieckmann cyclization step.
Abstract Monoterpene indole alkaloids (MIAs) are endowed with high structural and spatial complexity characterized by diverse biological activities. Given this complexity‐activity combination in MIAs, rapid efficient access to chemical matter related similar these would be highly desirable, since such compound classes might display novel bioactivity. We describe the design synthesis of a pseudo‐natural product (pseudo‐NP) collection obtained unprecedented MIA fragments through...
Metal chelation in tetramates may be ameliorated by changing the ligating group and steric blocking, which turn leads to a change their antibacterial properties; former was achieved replacement of an amide with C-9 C═N bond latter synthesis cysteine-derived functionalization at C-6 or enolic groups. In both cases, metal-chelating ability weak, loss activity observed. Tetramate alkylations extended tricarbonyl-conjugated system could under Mitsunobu conditions led regioisomers,...
The preparation of antioxidant starch with the activity glutathione peroxidase (GPx) for scavenging free radicals can not only enrich types modified but also alternate native GPx to overcome its drawbacks.
Peroxiredoxins (Prxs) widely exist in organisms and can prevent oxidative damage. Here, the characterization biological function of NdPrx3 from Neocaridina denticulata sinensis were analyzed. The coding sequence consists 684 bp open reading frame (ORF), encoding 227 amino acids with a predicted molecular weight 24.7 kDa theoretical pI 6.49. Multiple alignments showed that conserved domains NdPrx3, including catalytic triad, dimer interface, decamer peroxidatic, resolving cysteines, similar...